Original title: Voltammetric Determination of Tumor Biomarkers using Flow Injection Analysis with Amperometric Detection
Authors: Němečková-Makrlíková, Anna ; Matysik, F.-M. ; Navrátil, Tomáš ; Barek, J. ; Vyskočil, V.
Document type: Papers
Conference/Event: INTERNATIONAL STUDENTS CONFERENCE MODERN ANALYTICAL CHEMISTRY /13./, Prague (CZ), 20170921
Year: 2017
Language: eng
Abstract: Three tumor biomarkers (homovanillic acid, vanillylmandelic acid, and 5-hydroxyindole-3-acetic acid) have been determined by flow injection analysis with amperometric detection at screen-printed carbon electrodes in optimum medium of Britton-Robinson buffer (0.04 mol l(-1), pH = 2.0). Dependences of the peaks current on the concentration of biomarkers were linear in the tested concentration region from 0.05 to 100 mu mol l(-1), with the limits of detection of 0.065 mu mol l(-1) for homovanillic acid, 0.053 mu mol l(-1) for vanillylmandelic acid, and 0.033 mu mol l(-1) for 5-hydroxyindole-3-acetic acid (calculated from heights), and 0.024 mu mol l(-1) for homovanillic acid, 0.020 mu mol l(-1) for vanillylmandelic acid, and 0.012 mu mol l(-1) for 5-hydroxyindole-3-acetic acid (calculated fromareas), respectively.
Keywords: 5-hydroxyindole-3-acetic acid; flow injection analysis; homovanillic acid; homovanillic-acid; tumor biomarkers; urine; vanillylmandelic acid
Host item entry: PROCEEDINGS OF THE 13TH INTERNATIONAL STUDENTS CONFERENCE MODERN ANALYTICAL CHEMISTRY, ISBN 978-80-7444-052-6

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0291431

Permalink: http://www.nusl.cz/ntk/nusl-390776


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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers
 Record created 2019-01-07, last modified 2019-11-25


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