Název: A New evaluation of combined antitumor effects of natural and synthetic nuclear retinoid receptor ligands in human breast carcinoma cells
Autoři: Strouhalová, Dana ; Laštovičková, Markéta ; Bobál, P. ; Macejová, D. ; Mosná, B. ; Brtko, J. ; Bobálová, Janette
Typ dokumentu: Příspěvky z konference
Konference/Akce: CECE 2018. International Interdisciplinary Meeting on Bioanalysis /15./, Brno (CZ), 20181015
Rok: 2018
Jazyk: eng
Abstrakt: This work represents the study of the effects of biologically active ligands of nuclear retinoid X receptors, triorganotin compounds, on proteomic profile of MDA-MB-231 cells. We focused primarily on tributyl/phenyltin derivatives that suggest the combined antitumor effect when they are used with natural nuclear retinoid receptor ligand all-trans retinoic acid (ATRA). Proteomic strategies connected to PDQuest evaluation were applied in this study. Some specific proteins with tumor process association were chosen for more detail study. Our findings indicate that selected triorganotins derivatives resulted to significantly reduced level of studied proteins belonging to metabolic pathway or to other cellular processes as apoptosis or epithelial–mesenchymal transition. In the case of vimentin, the key protein of EMT process, the silencing was set up by triorganotin compounds and significantly enhanced by combination with ATRA. This additive effect on downregulation can result from the potential engagement of RXR/RAR heterodimer, considering co-addition of both partner ligands of mentioned heterodimer to the treatment.
Klíčová slova: breast carcinoma cells; nuclear retinoid X receptors; triorganotin compounds
Číslo projektu: SAV-18-16 (CEP)
Poskytovatel projektu: AV ČR
Zdrojový dokument: CECE 2018. 15th International Interdisciplinary Meeting on Bioanalysis, ISBN 978-80-904959-5-1

Instituce: Ústav analytické chemie AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný na externích webových stránkách.
Externí umístění souboru: http://www.ce-ce.org/user_uploads/program/CECE%202018%20Proceedings_WOS.pdf
Původní záznam: http://hdl.handle.net/11104/0291415

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-390770


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav analytické chemie
Konferenční materiály > Příspěvky z konference