Original title:
Synthesis of (purin-6-yl)acetates and their transformations
Translated title:
Syntéza (purin-6-yl)acetátů a jejich transformace
Authors:
Hasník, Zbyněk ; Hocek, Michal Document type: Papers Conference/Event: Symposium on Chemistry of Nucleic Acid Components /14./, Český Krumlov (CZ), 2008-06-08 / 2008-06-13
Year:
2008
Language:
eng Abstract:
[eng][cze] A novel approach to the synthesis of (purin-6-yl)acetates was developed based on Pd-catalysed cross-coupling reactions of 6-chloropurines with the Reformatsky agent. These intermediates were converted into various products by functional group transformations. Amides were prepared by amidation of ester group with amines, 6-(hydroxyethyl)purines by reduction by NaBH4, and beta-substituted 6-ethylpurines by mesylation of 6-(hydroxyethyl)purines and subsequent nucleophilic substitution.Byla vyvinut nový přístup k syntéze (purin-6-yl)acetátů založen na palladiem katalyzovaných cross-coupling reakcích 6-chlorpurinu s Reformackého činidlem. Tyto intermediáty byly přeměněny na další látky transformacemi funkčních skupin. Amidy byly připraveny amidacemi esterové skupiny, 6-(hydroxyethyl)puriny byly redukovány pomocí NaBH4, a beta-substituované 6-ethylpuriny byly připraveny mesylací 6-(hydroxyethyl)purinů a jejich následnou nukleofilní substitucí.
Keywords:
cross-coupling; nucleosides; purines Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP), 1QS400550501 (CEP) Funding provider: GA MŠk, GA AV ČR Host item entry: Chemistry of Nucleic Acid Components, ISBN 978-80-86241-29-6
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0161936