Original title: Aplikace mikro-objemové voltametrické cely pro stanovení doxorubicinu hydrochloridu
Translated title: Application of a Micro-Volume Voltammetric Cell for Determination of Doxorubicin Hydrochloride
Authors: Skalová, Štěpánka ; Navrátil, Tomáš ; Barek, J. ; Vyskočil, V.
Document type: Papers
Conference/Event: Moderní elektrochemické metody /38./, Jetřichovice (CZ), 20180521
Year: 2018
Language: cze
Abstract: [cze] [eng]
Byla úspěšně otestována aplikace mikro-objemové voltametrické cely na příkladu stanovení protinádorového léčiva doxorubicinu hydrochloridu. Objem analyzovaného vzorku činil 50 mikroL s LOD 0,39 micromol L-1 a LDR 0,4-10 mikromol L-1. Tato mikro-objemová cela byla také úspěšně použita k analýze tohoto analytu v modelových vzorcích pitné vody a lidské moči. Doxorubicin is an anticancer drug, which is used for treatment of various cancer types. It contains a quinone structure, similarly as some other drugs belonging to the same category (e.g., daunorubicin and epirubicin). Its monitoring can lead to optimization of individual patient dosages and increase chances for recovery of patients. A micro-volume voltammetric cell and differential pulse cathodic stripping voltammetry have been used for determination of doxorubicin hydrochloride. A volume of used sample was 50 microL. Limit of detection was 0.39 micromol L-1. An applicability of this method was verified on samples of drinking water and of human urine.
Keywords: Doxorubicine hydrochloride; Micro-volume; Voltametry
Project no.: GA17-05387S (CEP)
Funding provider: GA ČR
Host item entry: XXXVIII. Moderní elektrochemické metody. Sborník přednášek, ISBN 978-80-905221-6-9

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available on demand via the digital repository of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0284333

Permalink: http://www.nusl.cz/ntk/nusl-375651


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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers