Biotransformace anthelmintik a jiných cizorodých látek u helmintů a její přispění k rozvoji resistence

Prchal, Lukáš

Charles University, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate Mgr. Lukáš Prchal Supervisor prof. Ing. Barbora Szotáková, Ph.D. Title of Doctoral Thesis Anthelmintic and other xenobiotic biotransformation in helminths and its contribution to resistance development Parasitic helminths such as tapeworms, flukes or nematodes pose a threat for domestic, farm and wild living animals. Helminths cause significant health problems in animals. Moreover, they cause economical losses to farmers due to production decrease and treatment costs. The treatment with veterinary anthelmintics is still a basic method to fight off helminth infections. However, the long-term use of anthelmintics caused an emergence of resistance to anthelmintics. The increasing incidence of multiresistant strains of many helminth species is the greatest problem. Therefore, research of drug resistance mechanisms became an actual field of study. Increased biotransformation of anthelmintics, transport out of parasite bodies and contact of lower developmental stages with anthelmintics in the environment are some of possible mechanisms that lead to decrease of anthelmintic therapy effectivity and resistance development. The presented thesis focuses on the study of these mechanisms in three helminth...

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