Název: Molecular mechanisms involved in genotoxicity of industrially important monomers (styrene, 1,3-butadiene)
Překlad názvu: Molecular mechanisms involved in genotoxicity of industrially important monomers (styrene, 1,3-butadiene)
Autoři: Kuricová, Miroslava ; Vodička, Pavel (vedoucí práce) ; Černá, Marie (oponent) ; Machala, Miroslav (oponent)
Typ dokumentu: Disertační práce
Rok: 2009
Jazyk: eng
Abstrakt: [eng] [cze]
1 ABSTRACT The evaluation of individual health risk in workers occupationally exposed to industrial xenobiotics requires the use of a large number of parameters reflecting external exposure, internal exposure, biological effects and individual susceptibility. Environmental, occupational and life style-related exposure to mutagenic agents may contribute to cancer risk in humans. To prevent the potentially hazardous effects of such agents it is important to understand their mechanisms of action. Styrene is one of the most important monomer for producing polymers and copolymers in plastics, latex paints and together with 1,3-butadiene (BD) in the manufacture of synthetic rubbers. In this thesis, a large set of parameters, including markers of external and internal exposure and biomarkers of biological effects and susceptibility have been studied in relation to the occupational exposure to both styrene and BD. First part of the present study was focused on evaluating the role of various biomarkers to assess genotoxic effects of above mentioned xenobiotics. Biomarkers reflecting styrene- and BD-induced genotoxicity and mutagenicity: O6 -styrene guanine DNA adducts, haemoglobin adducts, single-strand breaks (SSBs), SSB Endo III sites, chromosomal aberrations (CA), hypoxanthine-guanine phosphoribosyltransferase... 2 Contents ABSTRACT........................................................................................................... 2 1. INTRODUCTION............................................................................................. 4 2. AIMS OF THE PROJECT:.............................................................................. 8 2. MATERIAL AND METHODS:....................................................................... 9 3. RESULTS: ....................................................................................................... 10 4. CONCLUSIONS.............................................................................................. 16 5. REFERENCES................................................................................................ 18 INDEX OF PUBLICATIONS:........................................................................... 21 Publications in extenso, which are the base of PhD. thesis .............................. 21 Publications in extenso, without relationship to the PhD thesis...................... 22 ABSTRACT The evaluation of individual health risk in workers occupationally exposed to industrial xenobiotics requires the use of a large number of parameters reflecting external exposure, internal exposure, biological effects and individual susceptibility....

Instituce: Fakulty UK (VŠKP) (web)
Informace o dostupnosti dokumentu: Dostupné v digitálním repozitáři UK.
Původní záznam: http://hdl.handle.net/20.500.11956/93741

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-370561


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Univerzita Karlova > Fakulty UK (VŠKP)
Vysokoškolské kvalifikační práce > Disertační práce