Original title: Patofyziologie kardiorenálních vztahů u pacientů s diabetes mellitus 2. typu
Translated title: Pathophysiology of cardiorenal interaction in patients with type 2 diabetes mellitus
Authors: Pecková, Marie ; Horáčková, Miroslava (advisor) ; Teplan, Vladimír (referee) ; Linhart, Aleš (referee)
Document type: Doctoral theses
Year: 2015
Language: cze
Abstract: Patients with type 2 diabetes mellitus (DM) suffer often from cardirenal syndrome because of high prevalence of cardiac and renal insufficiency. Functional deterioration of both organs depends on the compensation of DM, arterial hypertension and other metabolic parameters. We asked a question when did the cardiorenal interaction develop and which factors influenced its development. We examined 82 patients with type 2 DM with optimally corrected arterial hypertension, with well compensated diabetic metabolic disorder, without any clinical signs of heart disease and with normal or mild-to-moderate decrease in glomerular filtration rate according to MDRD equation (eGFR). We analysed the associations between eGFR and echocardiographic parameters of left ventricular (LV) diastolic function E' and E/E' on the basis of linear regression and multivariate analysis. According to multivariate analysis eGFR was significantly associated with E' and E/E' either. We assessed the association between E' and GFR by cluster analysis that divided whole cohort into two subgroups on the basis of the value E' = 7.1 cm s-1 . We analysed the associations between the parameters of LV diastolic function, eGFR and other parameters separately in both subgroups. We found out, that cardiorenal interaction (significant association...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/64432

Permalink: http://www.nusl.cz/ntk/nusl-333572


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses