Original title: Přívodná tepna dialyzačních cévních zkratů: model arteriální adaptace na vysoký průtok
Translated title: Feeding artery of vascular accesses for hemodialysis: model of arterial adaptation to high blood flow
Authors: Tuka, Vladimír ; Malík, Jan (advisor) ; Vízek, Martin (referee) ; Zicha, Josef (referee)
Document type: Doctoral theses
Year: 2008
Language: eng
Abstract: Background: Arteries adapt their diameter to changing haemodynamic conditions to maintain constant wall shear stress, the force generated by flowing blood on endothelial cells. The feeding artery of haemodialysis vascular accesses is a human model of arterial adaptation to chronically high blood flow and thus to high wall shear stress. The process of arterial adaptation is endothelium dependent. Endothelial dysfunction related to End-Stage Renal Failure, diabetes mellitus, dyslipidemia may impair also the dilatation of the feeding artery of vascular accesses. First the review of the literature presents in three parts different aspects of arterial adaptation: 1) arterial adaptation with focusing on the role of haemodynamic factors, 2) the influence of end-stage renal disease on arterial adaptation, 3) feeding artery of vascular accesses as a model of arterial response to chronic increase in blood flow. Methods: We examined the feeding artery of radial and brachial polytetrafluoroethylene grafts shortly after and one and two years after access creation. We used duplex ultrasonography to obtain internal diameter and blood velocity in the feeding arteries. We calculated wall shear rate as 4 x blood velocity / internal diameter and used it as approximation of wall shear stress. Results: In the first study we...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/15207

Permalink: http://www.nusl.cz/ntk/nusl-291430


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses