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Original title:
Separace a stanovení farmaceuticky významných sloučenin chemického a přírodního původu s využitím kapilárních elektroforetických metod
Translated title: Separation and determination of pharmaceutically important compounds of chemical and natural origin by capillary electrophoresis
Authors: Kavalírová, Andrea ; Pospíšilová, Marie (advisor) ; Jokl, Vladimír (referee) ; Sochor, Jaroslav (referee)
Document type: Doctoral theses
Year: 2007
Language: cze
Abstract: 13. SUMMARY This thesis deals with the results of applications of electrophoretic methods in the separation and determination of pharmaceutical important compounds of synthetic or herbal origin. In the theoretic part, the classification of the capillary electrophoretic methods is presented. Capillary zone electrophoresis, capillary izotachophoresis and micellar elektrokinetic chromatography were used in this work. These electro-migration methods represent extremely potent separation techniques. The most of the theoretic part is devoted to the popular topic of chiral separations. Especially CZE presents a competition to the HPLC methods in the area of chiral separations. Implementation of a chiral selector into a background electrolyte enables more dynamic and faster optimizing conditions used for chiral separation. That means better discrimination and lower price of analysis. In the result section the first three experimental works describe the application of CZE in pharmaceutical analysis to control the content and optical purity of pharmaceutical active compounds. Successful discriminations of racemic mixture of rivastigmine, tamsulosine and sibutramine, their determination in HVLP and optical purity control, show that the developed, optimized and validated CZE methods offer accurate and correct results....
Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/10831
Permalink: http://www.nusl.cz/ntk/nusl-282259
The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses
Translated title: Separation and determination of pharmaceutically important compounds of chemical and natural origin by capillary electrophoresis
Authors: Kavalírová, Andrea ; Pospíšilová, Marie (advisor) ; Jokl, Vladimír (referee) ; Sochor, Jaroslav (referee)
Document type: Doctoral theses
Year: 2007
Language: cze
Abstract: 13. SUMMARY This thesis deals with the results of applications of electrophoretic methods in the separation and determination of pharmaceutical important compounds of synthetic or herbal origin. In the theoretic part, the classification of the capillary electrophoretic methods is presented. Capillary zone electrophoresis, capillary izotachophoresis and micellar elektrokinetic chromatography were used in this work. These electro-migration methods represent extremely potent separation techniques. The most of the theoretic part is devoted to the popular topic of chiral separations. Especially CZE presents a competition to the HPLC methods in the area of chiral separations. Implementation of a chiral selector into a background electrolyte enables more dynamic and faster optimizing conditions used for chiral separation. That means better discrimination and lower price of analysis. In the result section the first three experimental works describe the application of CZE in pharmaceutical analysis to control the content and optical purity of pharmaceutical active compounds. Successful discriminations of racemic mixture of rivastigmine, tamsulosine and sibutramine, their determination in HVLP and optical purity control, show that the developed, optimized and validated CZE methods offer accurate and correct results....
Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/10831
Permalink: http://www.nusl.cz/ntk/nusl-282259
The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses
Record created 2017-04-25, last modified 2022-03-04