Original title: Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells
Authors: Tuháčková, Zdena ; Šloncová, Eva ; Hlaváček, Jan ; Sovová, Vlasta ; Velek, Jiří
Document type: Papers
Conference/Event: Biologically Acitve Peptides /6./, Praha (CZ), 1999-04-21 / 1999-04-23
Language: eng
Abstract: Using synthetic peptides which reproduce phosphoacceptor sites in the molecule of GSK-3, PKB an eIF2B, we found that phosphorylation and activity of PKB increased very early during in vitro differentiation induced by sodium butyrate. This was inhibited by wortmannin, the selective inhibitor of phosphoinositol-3 kinase, indicating that the control of PI3 kinase/PKB/GSK-3 signalling pathway is the early event of transient differentiation of the human colon cancer cells HT-29.
Project no.: CEZ:AV0Z5052915 (CEP), IZ3517 (CEP), GA312/97/1188 (CEP), GV312/96/K205 (CEP)
Funding provider: GA MZd, GA ČR, GA ČR
Host item entry: Collection of Czechoslovak Chemical Communications, ISSN 0010-0765

Institution: Institute of Molecular Genetics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0086897

Permalink: http://www.nusl.cz/ntk/nusl-28107


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Research > Institutes ASCR > Institute of Molecular Genetics
Conference materials > Papers