Original title: Nežádoucí metabolické účinky aripiprazolu v poly I:C modelu schizofrenie u potkana
Translated title: Aripiprazole-induced adverse metabolic alterations in a polyI:C neurodevelopmental model of schizophrenia in rats
Authors: Horská, K. ; Rudá-Kučerová, J. ; Dražanová, Eva ; Pistovčáková, J. ; Karpíšek, M. ; Kotolová, H. ; Demlová, R. ; Kašpárek, T.
Document type: Papers
Conference/Event: Česko-slovenská psychofarmakologická konference, Jeseník (CZ), 20170104
Year: 2017
Language: eng
Abstract: The aim of this study was to evaluate metabolic phenotype of poly I:C rat model and asses metabolic effects of chronic aripiprazole treatment with regard to complex neuroendocrine regulations of energy homeostasis. Altered lipid profile in poly I:C model was observed. Leptin and GLP-1 serum levels were significantly reduced, while ghrelin level was elevated. Our data indicate that dysregulation of adipose tissue endocrine function and gastrointestinal hormones is implicated in metabolic adverse effects of antipsychotics.
Keywords: aripiprazole; metabolic syndrome; poly I:C animal model; rat
Host item entry: Psychiatrie. Supplementum 1, ISSN 1211-7579

Institution: Institute of Scientific Instruments AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0267114

Permalink: http://www.nusl.cz/ntk/nusl-262641


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Conference materials > Papers