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Název:
Effect of exposure to bisphenol A on gene expression in the testicular tissue in male mice
Autoři: Dorosh, Andriy ; Elzeinová, Fatima ; Žatecká, Eva ; Kubátová, Alena ; Pěknicová, Jana
Typ dokumentu: Příspěvky z konference
Konference/Akce: XXth Symposium of Biology and Immunology of Reproduction with international participation, Třešť (CZ), 2014-05-22 / 2014-05-24
Rok: 2014
Jazyk: eng
Abstrakt: Laboratory of Reproductive Biology, Institute of Biotechnology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic Bisphenol A (BPA) is a synthetic, endocrine-disrupting compound able to directly bind estrogen receptors. Free BPA has been detected in human samples indicating that humans are internally exposed to BPA. The purpose of this study was to analyse the effect of BPA on the male reproductive system and testicular gene expression in germ cells. We studied the influence of long-term low concentration BPA exposition on male fertility in vivo in a two-generation study in C57BL/6 mouse strain. In this work, BPA was added with water at two environmentally relevant concentrations: 0, 4 and 4 µg/l. We measured the reproductive organs weight and sperm cells morphology and quality. Expression of genes involved in endocrine regulation and energy metabolism in testis was analysed after BPA exposure. Next, the epigenetic mechanisms of gene expression and regulation during the germ cell differentiation and effect of BPA will be analysed.
Klíčová slova: bisphenol A; gene expression; testicular tissue
Číslo projektu: CEZ:AV0Z50520701 (CEP), P503/12/1834, CZ1.05/1.1.00/02.0109
Poskytovatel projektu: GA ČR, GA MŠk
Zdrojový dokument: Book of abstracts XXth Symposium of Biology and Immunology of Reproduction with international participation
Instituce: Biotechnologický ústav AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0235853
Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-174972
Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Biotechnologický ústav
Konferenční materiály > Příspěvky z konference
Autoři: Dorosh, Andriy ; Elzeinová, Fatima ; Žatecká, Eva ; Kubátová, Alena ; Pěknicová, Jana
Typ dokumentu: Příspěvky z konference
Konference/Akce: XXth Symposium of Biology and Immunology of Reproduction with international participation, Třešť (CZ), 2014-05-22 / 2014-05-24
Rok: 2014
Jazyk: eng
Abstrakt: Laboratory of Reproductive Biology, Institute of Biotechnology, Academy of Sciences of the Czech Republic, v.v.i., Prague, Czech Republic Bisphenol A (BPA) is a synthetic, endocrine-disrupting compound able to directly bind estrogen receptors. Free BPA has been detected in human samples indicating that humans are internally exposed to BPA. The purpose of this study was to analyse the effect of BPA on the male reproductive system and testicular gene expression in germ cells. We studied the influence of long-term low concentration BPA exposition on male fertility in vivo in a two-generation study in C57BL/6 mouse strain. In this work, BPA was added with water at two environmentally relevant concentrations: 0, 4 and 4 µg/l. We measured the reproductive organs weight and sperm cells morphology and quality. Expression of genes involved in endocrine regulation and energy metabolism in testis was analysed after BPA exposure. Next, the epigenetic mechanisms of gene expression and regulation during the germ cell differentiation and effect of BPA will be analysed.
Klíčová slova: bisphenol A; gene expression; testicular tissue
Číslo projektu: CEZ:AV0Z50520701 (CEP), P503/12/1834, CZ1.05/1.1.00/02.0109
Poskytovatel projektu: GA ČR, GA MŠk
Zdrojový dokument: Book of abstracts XXth Symposium of Biology and Immunology of Reproduction with international participation
Instituce: Biotechnologický ústav AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0235853
Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-174972
Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Biotechnologický ústav
Konferenční materiály > Příspěvky z konference
Záznam vytvořen dne 2014-09-11, naposledy upraven 2021-11-24.