Original title: 5-(Pyren-1-yl)uracil UNA monomers: Synthesis, hybridization studies and i-motif stability
Authors: Perlíková, Pavla ; Pedersen, E. B. ; Wengel, J.
Document type: Papers
Conference/Event: Symposium on Chemistry of Nucleic Acid Components /16./, Český Krumlov (CZ), 2014-06-08 / 2014-06-13
Year: 2014
Language: eng
Abstract: We have used direct conjugation of a pyrene moiety to a uracil base in synthesis of novel pyrene-modified UNA building blocks. Oligonucleotides with bulge-incorporated pyrene-modified UNA monomers showed increased duplex thermal stability, whereas destabilizing effect was observed in fully matched duplexes and in i-motifs.
Keywords: 5-(pyren-1-yl)uracil UNA monomers; DNA; unlocked nucleic acids
Project no.: FP7-268776
Funding provider: European Research Council
Host item entry: Chemistry of Nucleic Acid Components. 16th Symposium, ISBN 978-80-86241-50-0

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0234441

Permalink: http://www.nusl.cz/ntk/nusl-174770


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers