Original title: Synthesis and biological properties of polysubstituted 5-nitrosopyrimidines
Authors: Janeba, Zlatko ; Čechová, Lucie ; Žurek, Jiří ; Procházková, Eliška ; Dračínský, Martin
Document type: Papers
Conference/Event: Symposium on Chemistry of Nucleic Acid Components /16./, Český Krumlov (CZ), 2014-06-08 / 2014-06-13
Year: 2014
Language: eng
Abstract: 2,4,6-Triamino-5-nitrosopyrimidines have been reported to contain a strong intramolecular hydrogen bond between the 5-nitroso and 4- or 6-amino groups, thus forming an additional pseudoring. Such analogues were speculated to be good mimics of fused bicyclic derivatives, e.g. purines. A series of novel polysubstituted 2-amino-5-nitrosopyrimidines, as potential structural mimics of modifi ed purine nucleos(t)ides well-known for their important biological properties, has been designed and synthesized. The physicochemical and biological properties of the prepared polysubstituted 2-amino-5-nitrosopyrimidines are being evaluated.
Keywords: intramolecular hydrogen bond; NMR spectroscopy; polysubstituted 5-nitrosopyrimidines
Project no.: VG20102015046 (CEP)
Funding provider: GA MV
Host item entry: Chemistry of Nucleic Acid Components. 16th Symposium, ISBN 978-80-86241-50-0

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0234286

Permalink: http://www.nusl.cz/ntk/nusl-174430


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