Název: The Synthesis, Surface Modification and Stability of SPIO Nanoparticles for MRI Application
Autoři: Kovář, D. ; Fohlerová, Z. ; Malá, A. ; Jiřík, Radovan ; Starčuk jr., Zenon ; Kalina, M. ; Skládal, P.
Typ dokumentu: Příspěvky z konference
Konference/Akce: NANOCON 2013. International Conference /5./, Brno (CZ), 2013-10-16 / 2013-10-18
Rok: 2013
Jazyk: eng
Abstrakt: The biocompatibility and biodegradability of new magnetic resonance imaging (MRI) contrast agents is high-ly desired. The superparamagnetic iron oxide (SPIO) nanoparticles are suitable candidates for these pur-poses. Here the co-precipitation technique for synthesis of monodispersed SPIO nanoparticles is pre-sented. The critical point of the synthesis is core formation and consequent crystal growth. The conditions for core formation (time, temperature, rate of base addition) were optimised. The nanoparticles were stabilised by either silanisation or polymer coating (cationic chitosan, poly-D-Arg, dextran, gelatine, hyaluronic acid). The stability was investigated in physiological pH, different ionic strength solutions, PBS-albumine solution or blood plasma. The biocompatibility was tested in vitro either in the presence of Saccharomyces cerevisiae or erythrocytes suspension. The size and shape was investigated by atomic force microscopy (AFM) and scanning electron microscopy (SEM). The molecular structures of nanoparticles were investigated by FTIR (Fourier transform infrared spectroscopy). The iron cations were determined using the Prussian blue staining test. The stability of nano-particles was investigated by the zeta potential using the method of electrophoretic light scattering (ELS).
Klíčová slova: nanoparticles; surface modifications
Číslo projektu: ED0017/01/01
Poskytovatel projektu: GA MŠk
Zdrojový dokument: NANOCON 2013. 5th International Conference Proceedings, ISBN 978-80-87294-44-4

Instituce: Ústav přístrojové techniky AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0228772

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-170088


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav přístrojové techniky
Konferenční materiály > Příspěvky z konference