Název: Tree of life in a gappy genomic era
Autoři: Martínková, Natália
Typ dokumentu: Příspěvky z konference
Konference/Akce: Summer School on Computational Biology /8./, Mikulov (CZ), 2012-09-12 / 2012-09-15
Rok: 2012
Jazyk: eng
Abstrakt: Increasing volume of publicly available DNA sequence data enables comprehensive studies that address integrative questions. For these projects, bioinformatic analysis requires advanced methods and computational infrestructure. I present the character of DNA sequence matrices for multilocus datasets, which contain large portions of missing data. A condition critical for analysis of multilocus data is that datasets for all loci or genes need to have partially overlapping taxon sets. The work-flow for analysing such data differs between supermatrix and supertree estimation of species trees. In the supermatrix approach, aligned sequences for all genes are concatenated and the species tree is estimated directly from a partitioned matrix. In the supertree approach, gene sequence alignments are used for inference of gene trees. Those are then combined into a species supertree. Smaller projects could benefit from utilising all available information in the supermatrix. Larger projects should rely on supertree methods for computational optimisation.
Klíčová slova: DNA sequence evolution; multilocus genotyping; phylogeny; supermatrix; supertree
Zdrojový dokument: Proceedings of the 8th Summer School in Computational Biology: From analysis of genomic data to clinical applications - case studies, ISBN 978-80-7204-804-5

Instituce: Ústav biologie obratlovců AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0223585

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-156454


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav biologie obratlovců
Konferenční materiály > Příspěvky z konference