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Physiotherapy in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation
Holasová, Adéla ; Novotný, Ondřej (advisor) ; Ortová, Marta (referee)
The bachelor's thesis is devoted to the issue of physiotherapy intervention in patients with multiple myeloma hospitalized in the transplant unit, who are currently in a state shortly after high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation. The theoretical part includes the basic classification of haematoma-oncological malignancies, a description of the multiple myeloma disease, its incidence and prevalence, symptoms of the disease, diagnosis, treatment options, the effect of long-term hospitalization on the body, symptoms of the disease relevant for the initiation of physiotherapy intervention. The conclusion of the theoretical part deals with the current issue of physiotherapy in patients with multiple myeloma. The practical part consists of three case reports of patients with multiple myeloma who were hospitalized in the transplant unit shortly after undergoing high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation. Their case reports include an initial examination, a description of therapies and an exit examination of individual patients. The practical part also introduces a set of exercises, which should serve as inspiration for patients for suitable exercises that they can perform themselves during the day, but only after...
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Multiple myeloma- diagnosis and treatment
Jungová, Alexandra ; Vokurka, Samuel (advisor) ; Krejčí, Marta (referee) ; Minařík, Jiří (referee)
Multiple myeloma is an agressive hemato-oncological disease the diagnosis and treatment possibilities of which have been developing for the last 15 years. The diagnostic methods include flow cytometry which uses antigen detection to distinguish between pathological and physiological plasmocytes. One of the monitored markers is marker CD45 which could be, according to our monitoring, of a negative prognostic value. 71 patients in our group were divided according to the intensity of CD45 antigen expression and the group with a lower expression showed a statistically higher risk of relapse within 12 months 62% vs. 25 % (p=0,0011). We did not find any connection with the influences of induction therapy or cytogenetics which are otherwise considered the most important prognostic markers. Multiple myeloma treatment involves a lot of combined protocols; and the repeated autologous transplantation is still considered to be the most efficient. We observed more positive results in planning the second autologous transplant early in patients who reached just partial remission after the 1st autologous transplant - significantly better TFS (treatment free survival) and overall survival (OS) were in the group of patients with early tandem transplantation: 18 months vs. 10 months (p=0.04) and the OS median was not reached...
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Multiple myeloma- diagnosis and treatment
Jungová, Alexandra ; Vokurka, Samuel (advisor) ; Krejčí, Marta (referee) ; Minařík, Jiří (referee)
Multiple myeloma is an agressive hemato-oncological disease the diagnosis and treatment possibilities of which have been developing for the last 15 years. The diagnostic methods include flow cytometry which uses antigen detection to distinguish between pathological and physiological plasmocytes. One of the monitored markers is marker CD45 which could be, according to our monitoring, of a negative prognostic value. 71 patients in our group were divided according to the intensity of CD45 antigen expression and the group with a lower expression showed a statistically higher risk of relapse within 12 months 62% vs. 25 % (p=0,0011). We did not find any connection with the influences of induction therapy or cytogenetics which are otherwise considered the most important prognostic markers. Multiple myeloma treatment involves a lot of combined protocols; and the repeated autologous transplantation is still considered to be the most efficient. We observed more positive results in planning the second autologous transplant early in patients who reached just partial remission after the 1st autologous transplant - significantly better TFS (treatment free survival) and overall survival (OS) were in the group of patients with early tandem transplantation: 18 months vs. 10 months (p=0.04) and the OS median was not reached...
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The Use of Sensory Motor Stimulation in Patients with Multiple Myeloma at the Transplant Ward
Havlová, Lucie ; Havlová, Martina (advisor) ; Hálková, Jindřiška (referee)
Title: The Use of Sensory Motor Stimulation in Patients with Multiple Myeloma at the Transplant Ward Abstract: The bachelor thesis deals with the use of the sensory motor stimulation technique in patiens with multiple myeloma who are hospitalized in a transplant unit. The thesis is divided into the theoretical and practical parts. In the theoretical part, multiple myeloma, its etiology, symptoms and the treatment are characterized. Then it concentrates on the course of autologous transplantation and the patient's hospitalization in a transplant unit. This part of the thesis also deals with the influence of motion activity on the human body and consequences of physical inactivity. The sensory motor stimulation technique, its nature, conception and methodological procedure are also explained in this part. The practical part of the thesis focuses on the use of the sensory motor stimulation in two patiens with multiple myeloma hospitalized in a transplant unit. It is composed of two case reports. The aim of the bachelor thesis is to find out the influence of sensory motor stimulation on a physical condition of the patiens after autologous transplantation and suitability of its integration into the rehabilitation programme of the transplant unit. Key words: Multiple myeloma, autologous transplantation,...
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Nursing of children on a transplant unit
HERKUCZOVÁ, Lenka
Oncological disease is very stressful and worrying for everyone. In the second half of 20th century, tumor disease became the second most frequent cause of death of children and young adults. They bring a major intervention to the child´s life, to the life of his or her family and to the lives of people close to the child. The research was proceeded on transplant unit and standard unit in Children´s Cancer Hospital. The objective of the thesis was to find out the specifics of the care on the transplant unit and based on obtained results determine actions that could make the care for children in the transplant unit more pleasant and improve the quality of the care. The objectives were fulfiled. Based on the research four hypothesis were formed.
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