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Measuring Czechoslovaks. Czech Society of Biotypology and Constitutional Medicine in Czechoslovakia 1937-1959
Musil, Jan ; Hermann, Tomáš (advisor) ; Šimůnek, Michal (referee) ; Svobodný, Petr (referee)
This doctoral thesis describes the formation, activities and dissolution of the Czech Society of Biotypology (1937-1959), herein used as an example of impact of the constitutional typology (human typology science) on the Czechoslovak medicine. Human constitution science (in French and Romance languages called biotypology) classifies individual human beings on the base of morphological and physiological characteristics, with particular emphasis on forecast of future trends. The core of the science focuses on correlation between the physical appearance of a person and his/her mental characteristics. The Czech Society of Biotypology (Česká společnost biotypologická - ČSB) was founded with ambitions not only to study human beings, but also to increase their potential. The whole movement was therefore conceived as an example of a sanitation scientific program in accordance with the governmental interest in rationalization of population care. The methodology of the thesis is based on Foucault's concept of biopower - change of power strategies and their constitutive influence on the development and change of social relations, values and individual strategies of persons. The story of formation and dissolution of ČSB is interpreted as a consequence of these changes. The core of the thesis consists of a...
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Research Data Analysis Based on the Collection of Dissertation Theses of Charles University in Prague with Regard to Long-term Digital Preservation
Pavlásková, Eliška ; Krbec, Pavel (advisor) ; Ivánek, Jiří (referee) ; Bartošek, Miroslav (referee)
This dissertation thesis focuses on research data and their use in academics from the point of view of long-term preservation. It maps usage of research data at Charles University in Prague, analyses them and lays the foundation for further research. The first part of the text focuses on the theory of long term preservation and describes the most relevant concepts regarding users, storage and structure of research data. The second part is devoted directly to research data. It consists of definition of research data, the short explanation of their importance and sources, and the model of their lifecycle. The pivotal part of the thesis is the description and the results of the research itself. The research was conducted during the year 2015 and was based on a sample of dissertation theses from the collections of Charles University in Prague. Collected data were analysed by the methods of content analysis and grounded theory. Results are presented in two main parts - content analysis results with regard to differences among science, social science and humanities, and qualitative analysis results. Powered by TCPDF (www.tcpdf.org)
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Molecular mechanisms of Wnt signalling in mammalian cells
Lukáš, Jan ; Kořínek, Vladimír (advisor) ; Kohoutová, Milada (referee) ; Macůrková, Marie (referee)
Wnt signalling represents an important mechanism participating in control of cellular and developmental processes, including establishment of cell polarity, cell fate specification, stem cell self-renewal, tissue patterning and organogenesis, homeostasis maintenance and regeneration. Misregulation of the Wnt signalling during embryogenesis leads to developmental defects while aberrant activation later in development is associated with degenerative diseases and a number of cancers. The presented PhD thesis is based on four original publications that deal with the post-translational modifications of Wnt ligands and molecular mechanisms contributing to the regulation of a transcriptional profile of the so-called canonical Wnt pathway. Wnt signalling pathway is used repetitively both in time and different cellular contexts throughout development of multicellular organisms. Inevitably, in each single situation -catenin/TCF complexes, the downstream effectors, induce only subsets of all potential target genes. How this differential tissue- and stage-specific control over various subsets of target genes is achieved with such a limited number of nuclear effectors is not fully understood. Along with the expression of specific LEF/TCF family members or their variants containing different functional domains...
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