|
|
Measurement and Evaluation of Business Performance
Plevová, Pavlína ; Hornungová, Jana (referee) ; Kocmanová, Alena (advisor)
The bachelor's thesis focuses on the measurement and evaluation of the financial performance of the company ZEMAS AG, a.s. between 2017 and 2021. The work consists of three parts. In the first part, the theoretical starting points are defined, where the individual methods of financial analysis and the necessary indicators are described. The second part focuses on the analysis of the chosen company using the methods described in the first part and comparing the results with the competing company. The last part follows, in which proposals for improving the company's situation are presented.
|
|
|
The influence of variants in genes associated with carcinogenesis on predisposition to and phenotype of hereditary and sporadic tumour diseases of gastrointestinal tract
Vasovčák, Peter ; Křepelová, Anna (advisor) ; Kohoutová, Milada (referee) ; Plevová, Pavlína (referee)
This PhD. thesis deals with four different topics for which an increased risk of the development of colorectal cancer (CRC) is the common denominator. The first part is aimed to Cowden syndrome (CS), the second to Peutz-Jeghers syndrome (PJS), the third to sporadic CRCs in Czech population and the fourth is dedicated to a patient with a constitutional mismatch repair deficiency syndrome (CMMR-D) and a particular mutational profile. Cowden syndrome (CS) is an autosomal dominant disorder with a predisposition to tumours, especially breast, thyroid and uterine tumours. Pathognomonic features are mucocutaneous lesions with almost a 100% penetrance until 30 years of age (1). Despite the established diagnostic criteria (2), classification of the CS is a challenge due to extremely variable phenotypic spectra and a variable expression of the disease. Molecular-genetic analysis of the causal PTEN gene may confirm or exclude the suspicion of the CS (3). We have analysed and described two patients (Publication 1 and 2) who presented with variable expression of the disease. First one manifested with massive polyposis of the gastrointestinal tract (GIT) and the other patient developed the malignant disease. Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder characterised by the presence of mucocutaneous...
|
|
| |
|
| |
guest ::
RSS feed.