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The role of human papilloma viruses in ethiopathogenesis malignant tumors in sinonasal area
Sieglová, Kateřina ; Nachtigal, Petr (advisor) ; Petera, Jiří (referee)
The aim of this thesis is the comparison of immunohistochemical and molecular biological methods for the detection of human papillomavirus (HPV) in tumour tissue and their subsequent use in the study of HPV role in the etiopathogenesis of malignant tumors of sinonasal region. Several methods for the purpose of HPV detection were applied: in situ hybridization, immunohistochemical detection of expression of p16INK4a protein, classic polymerase chain reaction combined with two different enzyme immunoassay detection methods, and reverse hybridization, followed by polymerase chain reaction with real time reverse transcription. All methods (p16 DNA in situ hybridization, RNA in situ hybridization, quantitative polymerase chain reaction with reverse transcription - RT-qPCR mRNA) used for the detection of HPV performed very well when compared, showing concordance with statistical significance p ˂ 0,0001. Detection of p16 vs. DNA polymerase chain reaction (PCR) had correlation coefficient p = 0.004 in the whole group, and p = 0.002 in the subgroup of squamous cell carcinoma (SCC). Correlation coefficient between detection of p16 and overall HPV status was 0,659 for entire set and 0,864 for set of SCC, indicating significant linear dependence. Immunohistochemical detection of p16 in combination with the...
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Combined treatment of advanced head and neck cancer with radiotherapy and cycooxygenase-2 inhibitors (phase I study)
Halámka, Magdalena ; Petera, Jiří (advisor) ; Soumarová, Renata (referee) ; Kubeš, Jiří (referee)
Combined treatment of advanced head and neck cancer with radiotherapy and cycooxygenase-2 inhibitors (phase I study) This paper describes the course and presents the outcomes of a original phase I study of combined treatment of advanced head and neck cancer using standard radiotherapeutic technique and COX2 inhibitor (Celebrex) as a potentiating agent. The primary goal of the study was identifying of the maximum tolerated dose of Celebrex for the purpose of further clinical investigation. In the theoretical introduction I present data on the incidence and mortality of HaN cancer worldwide and in the Czech republic, further preclinical data justifying use of Celebrex in combined treatment with radiotherapy. Special emphasis was put on presentation of local data systematically gained in Clinic of Oncology in Ostrava where this study has been conducted. These data include an overview of incidence, mortality, therapeutic methods and treatment toxicity profiles. Since the phase I study as such does not include comparison with control patient group, it is necessary to be aware of local standards. This is the background to establish inclusion criteria for patient recruitment, toxicity evaluation and setting maximum tolerance dose criteria. This study furthermore investigates expression of COX2 in tumor tissue and...
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Epidermal growth factor receptor as a predictor of tumor response to preoperative chemoradiation in locally advanced gastric carcinoma
Sirák, Igor ; Petera, Jiří (advisor) ; Šlampa, Pavel (referee) ; Soumarová, Renata (referee)
The purpose of my doctoral thesis was a retrospective evaluation whether the intensity of epidermal growth factor receptor (EGFR) expression in tumor biopsy predicts tumor response to preoperative chemoradiotherapy in patients with locally advanced gastric carcinoma. Thirty-six patients with gastric adenocarcinoma in clinical T2-4 stage and/or with nodal metastases were studied. Preoperative treatment consisted of 30-45 Gy of gastric irradiation with continuous 5-fluorouracil and weekly cisplatin. Surgical resection was performed 4-6 weeks later. EGFR expression in pretreatment tumor biopsies was assessed by immunohistochemistry. Level of EGFR expression was determined from the intensity and extent of staining. Tumor response after chemoradiotherapy was defined as a reduction of at least one T-stage level and/or finding of intense tumor regression in histopathologic examination. Seventeen patients responded to preoperative chemoradiation - 8 patients (22%) had pathologic complete response, 9 patients (25%) were downstaged. Positive EGFR expression was found in 8 tumors (22%), and represented a significant predictive marker of poor tumor response in multivariate logistic regression analysis (p = 0.015). Response to chemoradiotherapy was found in 57% (16/28) of EGFR negative patients and in 13% (1/8)...
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Forecast models construction of gold and silver prices
Tůmová, Petra ; Petera, Jiří (advisor)
Diplomová práce je zaměřena na analýzu vývoje časových řad, nominálních cen zlata a stříbra od roku 1968 do roku 2014 a následné využití ARIMA modelu pro sestavení predikce cen obou komodit. Při sestavování predikce bylo využito statistického softwaru Statistica od společnosti StatSoft ČR s. r. o. (licence získána z ČZU) a tabulkového procesoru Microsoft Excel.
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Statistical analysis of traffic Babylon entertainment center in 2012-2015 .
Knajbelová, Barbora ; Petera, Jiří (advisor) ; Grosz, Jan (referee)
The bachelor's thesis focuses on the traffic of the entertainment Center Babylon located in the center of Liberec. Methodology includes the theory of time series analysis and possibilities of prediction using trend functions and index analysis. The aim of the thesis the practical part is actually to perform a statistical analysis of traffic of entertainment Center Babylon in Liberec in the years 2012 - 2015. In the practical part are commented specific values of the traffic, evaluated elementary statistics (index analysis), flatted time series by using the chosen method and using the method of trend functions is determined prediction for the next 3 periods.
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Analysis of development concerning use of electronic marketplaces in Ministry of Transport
Jahoda, Pavel ; Petera, Jiří (advisor) ; Grosz, Jan (referee)
This bachelor diploma thesis is focused on an analysis using the electronic market system by means of the time series theory. The analysis covers a mentioned process of public procurement made by contract owners registered in Tendermarket electronic marketplace and researches closely the public procurement process at Ministry of Transport. An analysis of eight different indicators, of which the total defines the resulting trend of this significant method use applied during public funds gaining, is included. Given the volume of public sector contracts, the electronic form of tendering is one of important means to reach an efficacy of expended funds. The result provides particular indicator values of the marketplace use and a future prognosis.
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Statistical analysis of the airline transport by appropriate quantitative methods
Dostálová, Hana ; Petera, Jiří (advisor) ; Lenka, Lenka (referee)
The theme of the air transport is becoming increasingly popular among people nowadays. Therefore, this Master thesis deals with a statistical analysis of the Czech airline Czech Airlines j.s.c. The system of timelines from 2003 to 2014 was used to analyse the number of transported passengers regarding passenger traffic and the number of transported goods and mail within the air freight transport.
The theoretical part of the paper is based on a literary review where basic terms of the air transport and timelines are described. The aim of the analysis is to apply particular trendy features on indicators of the research. According to the selected trend, predictions for the following the three seasons are made.
Subsequently, the statistical analysis is evaluated and recommendations aimed
at improving the future situation of the company are made.
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Statistical analysis of the Aviation by appropriate quantitative methods
Kadleček, Václav ; Petera, Jiří (advisor) ; Lenka, Lenka (referee)
This Masters Thesis is divided into two parts. A theoretical and a practical part. In the theoretical part a history of aviation in the Czech Republic and its development is described as well as the division of the aviation and the airspace of the Czech Republic, the demarcation of airports and global events which have an influence on aviation in the Czech Republic.
A practical part is focused on the analysis of time series of the capacity utilization of selected Czech airports and the airspace of the Czech Republic from the point of view of the number of the aircraft movements. In this part a proportion of the individual airports in full use of the airspace of the Czech Republic is expressed and the elementary characteristics and descriptive statistics are calculated. Further on an influence of the mentioned global events on the development of on selected airports and in the airspace of the Czech Republic is examined. Last but not least the development of the capacity utilization of the selected time series for 2015 is forecast followed by assessment of the airports´ capacities with an evaluation whether the capacity of the selected airports is sufficient or not.
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