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Reproductive system in Human biology lessons at secondary school
NAVRÁTILOVÁ, Adéla
This diploma thesis deals with the topic of teaching the human reproductive system at secondary schools both in the Czech Republic and in selected German federal states, Bavaria and Saxony. The aim was first to discover the differences in teaching the reproductive system among the chosen countries and secondly to create own teaching units regarding this topic and utilize them in classes. The differences between Czech, Saxon, and Bavarian types of teaching were supported by curricular documents and a questionnaire distributed among teachers from selected countries. Czech curricular documents outline the teaching of the reproductive system more briefly compared to the German ones. The questionnaire provided specific information incorporating the methods used in teaching. Furthermore, this diploma thesis contains two fully designed teaching units, including both materials for students and methodological instructions for teachers. The practical implementation of the proposed teaching units is evaluated at the very end of this thesis.
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The role of S100A11 protein (calgizzarin) in rheumatoid arthritis pathogenesis
Navrátilová, Adéla ; Andrés Cerezo, Lucie (advisor) ; Štěpánek, Ondřej (referee)
Rheumatoid arthritis (RA) is a systemic connective tissue autoimmune disease which is characterized by persistent inflammation of the synovial tissue, joint destruction and visceral organs and vessels damage. The RA joint environment contains pro-inflammatory molecules and immune cells. Small calcium-binding proteins of the S100 family are also known to be involved in the inflammatory process of RA, and some of them have been studied in our laboratory. One member of this family, S100A11 (calgizzarin), is well described in oncological diseases but its role in autoimmune diseases has not yet been described. Neutrophil extracellular traps (NETs), which are a potential source of autoantigens and immunoactive molecules, also contribute to the chronic inflammatory process in RA. The aim of our study was to investigate S100A11 with the focus on its role in the processes of inflammation and tissue destruction and to assess its possible association with NETs. Using in vitro experiments and molecular methods (reverse transcription, quantitative polymerase chain reaction (qPCR) and multiplex assay) we have shown that S100A11 exerts its pro-inflammatory effect on mononuclear cells via toll-like receptor (TLR)-4, however there was not any significant effect of S100A11 on the production of pro-inflammatory...
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Xenobiotické látky jako endokrinní disruptory v přírodním prostředí se zřetelem k přírodním vodám
NAVRÁTILOVÁ, Adéla
The thesis examines xenobiotic compounds with endocrine disruption activities. It introduces fundamentals of the human endocrine system and elucidates mechanisms of the endocrine disrupting action together with factors affecting the endocrine disruption processes. Furthermore, it provides an overview of compounds with endocrine disruptive activity and examples of diseases for which endocrine disruption is considered to be a contributing factor for their onset. The thesis presents studies that demonstrate data about endocrine disruptors concentrations in wastewaters and natural surface waters and describes methods used for the detection of these compounds.
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The role of myeloid dendritic cells in allergic diseases
Navrátilová, Adéla ; Hrdý, Jiří (advisor) ; Hájková, Michaela (referee)
Dendritic cells (DC) of hematopoietic origin can be distinguished into cells originating from the myeloid (mDC) or lymphoid lineage. DCs of both branches are able to uptake the antigens, present their samples to T-lymphocytes and polarize the immune response. Lymphoid line DCs are specialized in fighting viruses and they are an important source of interferon alpha. MDCs, which engage antigens as one of the first cells, play an important role in allergies, which are a current problem. Allergy is defined as an inadequate immune response to environmentally nonharmful antigens, and asthma, allergic rhinitis, atopic dermatitis and food allergy are among the most common allergic diseases. This work focuses on the role of mDC in the pathogenesis of allergic diseases and their possible use in treatment. Furthermore, this paper describes the differences between healthy and allergic individuals in terms of functional changes of mDC and differences between mature and immature immune system. Key words: dendritic cells, allergic diseases, cytokines, newborn immune system
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