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	Acyklické nukleosidfosfonáty obsahující O-substituované hydroxypyridinaminy a diaminy jako nukleobase Otmar, Miroslav ; Masojídková, Milena ; Holý, Antonín Congeners of the PMEO class of acyclic nucleoside phosphonates containing pyridine instead of pyrimidine ring were synthesized. Detailed record
	Design a syntéza 5,6-disubstituovaných uracilových derivátů jako účinných inhibitorů thymidinfosforylasy Nencka, Radim ; Votruba, Ivan ; Hřebabecký, Hubert ; Tloušťová, Eva ; Horská, Květoslava ; Masojídková, Milena ; Holý, Antonín We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases. Detailed record
	Syntéza nových racemických konformačně omezených karbocyklických nukleosidů Šála, Michal ; Hřebabecký, Hubert ; Masojídková, Milena ; Holý, Antonín Novel racemic conformationally locked nucleosides, derived from bicyclo[2.2.1]heptene or heptane, were prepared and tested for their biological activity. Detailed record
	Syntéza a vlastnosti chirálních acyklických nukleosid bisfosfonátů s otevřeným kruhem Doláková, Petra ; Masojídková, Milena ; Holý, Antonín A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety. Detailed record
	Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds Otmar, Miroslav ; Masojídková, Milena ; Votruba, Ivan ; Holý, Antonín 2,6-Diamino-9-benzyl-9-deazapurine and 9-benzyl-2,6-bis(benzylamino)-9-deazapurine were synthesized by reductive cyclization of the corresponding 6-cyanomethyl-5-nitropyrimidines. Both compounds exhibit cytostatic activity in human T-lymphoblastoid CCRF-CEM cells. Detailed record
	Isosteric phosphonate mono-and oligonucleotides originating from 4',5'-didehydronucleoside precursors: some synthetic possibilities and limitations Točík, Zdeněk ; Liboska, Radek ; Barvík, I. ; Buděšínský, Miloš ; Masojídková, Milena ; Kavenová, Ivana ; Rosenberg, Ivan The work deals with aspects of synthesis and properties of isosteric phosphonate analogs of 5'-monophosphates and with structure-properties relationship of the related oligothymidylates. Detailed record
	Synthesis of .I.N./I.3-substituted isoguanine derivatives of acyclic nucleotide phosphonates Alexander, Petr ; Holý, Antonín ; Masojídková, Milena Detailed record
	Significant influence of (.I.N,N./I.-dimethylamino)methylene protection at .I.N./I..sup.6./sup.-position of adenine on regioselectivity of alkylations: selective synthesis of 7-substituted adenines Hocková, Dana ; Masojídková, Milena ; Holý, Antonín Detailed record
	Synthesis of .I.N./I..sup.4./sup.-alkyl-5-azacytidines and their base pairing with carbamoylguanidines - a contribution to explanation of the mutagenicity of 5-aza-2'-deoxycytidine Pískala, Alois ; Hanna, N. ; Masojídková, Milena ; Otmar, Miroslav ; Fiedler, Pavel Detailed record
	Synthesis of ŕ-hydroxyphosphonate analogs of Apa and UV spectroscopy study on their complexes with poly(U) Králíková, Šárka ; Buděšínský, Miloš ; Masojídková, Milena ; Kavenová, Ivana ; Rosenberg, Ivan Detailed record

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