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Modulation of pKa of the recognition moiety of azaphthalocyanine sensors II.
Karlíková, Martina ; Zimčík, Petr (advisor) ; Zitko, Jan (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Martina Karlíková Supervisor: prof. PharmDr. Petr Zimčík, Ph.D. Title of diploma thesis: Modulation of pKa of the recognition moiety of azaphthalocyanine sensors II. Our research group recently developed the sensors based on azaphthalocyanine (AzaPc) core containing one or two phenolic groups as recognition moiety and because of them, the AzaPcs can be utilized as fluorescent sensors. The fluorescent state of the molecule depends on the pH of the environment and the pKa of the recognition moiety. The latter can be modified by altering the substituents on phenol. The formation of AzaPcs was initiated by the synthesis of their precursors. In most of the cases, the starting material was 4-hydroxyacetophenon that was modified by electrophilic substitution. The products were oxidized to corresponding vicinal ketoaldehydes using selenium dioxide and immediately condensed with diaminomaleonitrile to substituted pyrazine-2,3-dicarbonitriles. Synthesis were completed by the cyclotetramerization reaction of this dicarbonitrile with 5,6-bis(tert-butylsulfanyl)pyrazine-2,3-dicarbonitrile using magnesium butoxide as initiator. Six different congeners were obtained by this...
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Modulation of pKa of the recognition moiety of azaphthalocyanine sensors II.
Karlíková, Martina ; Zimčík, Petr (advisor) ; Zitko, Jan (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Martina Karlíková Supervisor: prof. PharmDr. Petr Zimčík, Ph.D. Title of diploma thesis: Modulation of pKa of the recognition moiety of azaphthalocyanine sensors II. Our research group recently developed the sensors based on azaphthalocyanine (AzaPc) core containing one or two phenolic groups as recognition moiety and because of them, the AzaPcs can be utilized as fluorescent sensors. The fluorescent state of the molecule depends on the pH of the environment and the pKa of the recognition moiety. The latter can be modified by altering the substituents on phenol. The formation of AzaPcs was initiated by the synthesis of their precursors. In most of the cases, the starting material was 4-hydroxyacetophenon that was modified by electrophilic substitution. The products were oxidized to corresponding vicinal ketoaldehydes using selenium dioxide and immediately condensed with diaminomaleonitrile to substituted pyrazine-2,3-dicarbonitriles. Synthesis were completed by the cyclotetramerization reaction of this dicarbonitrile with 5,6-bis(tert-butylsulfanyl)pyrazine-2,3-dicarbonitrile using magnesium butoxide as initiator. Six different congeners were obtained by this...
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Business plan - „Flat in your pocket, Ltd.“
Karlíková, Martina ; Machek, Ondřej (advisor) ; Špička, Jindřich (referee)
The aim of this work is to develop such a business plan which would serve as a suitable basis for further negotiations with banks, suppliers, etc., and also as a springboard to launch own business. Another aim of this work is an evaluation of whether such a project has a chance to survive in the competitive environment. The work includes theoretical background of the company establishment and development of a business plan. The following is a description of the company, situational analysis and analysis of competitors and customers. The next part deals with marketing and production plan. The last part contains financial plan with prediction of future development, risk analysis and final assessment.
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Employee training and development in company Kovolis Hedvikov a.s.
Karlíková, Martina ; Němec, Otakar (advisor) ; Campbell, Jan (referee)
This thesis analyzes the approach to education in company Kovolis Hedvikov a.s. The aim is to assess its benefits for the company, effectiveness of the training, employee satisfaction with their own improvement and possible future development in the company. The first part is devoted to the theoretical starting-points, such as theory of learning, forms and methods of education and development, identification of training needs, legislative requirements for staff training, etc. The practical part describes the actual corporate strategy, training methods used, all the activities necessary for providing training, planned educational events, exploiting opportunities for education and utilization of funds for training, staff motivation to learn and develop. On the basis of these data the thesis identifies weaknesses in the actual approach to employee development. Finally, there are described recommendations for next steps, which may have a positive impact on long-term operation of the company.
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