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Significance of subclassification of sentinel lymph involvement in breast cancer for following surgical treatment
Červinka, Vladimír ; Jandík, Pavel (advisor) ; Schützner, Jan (referee) ; Fait, Vuk (referee)
Summary of histopathological analysis Sentinel lymph node biopsy is relatively new staging method in breast cancer women .Sentinel lymph nodes are assessed by hematoxylin eosin (HE) and by immunohistochemistry (IHC). The reason of the histopathological analysis of sentinel lymph nodes was to compare histological work up by HE with histological work up by IHC and based on this comparisone find if immunohistochemical examination of sentinel lymph nodes brings benefit to the patients or not. The goals of the histopathological analysis were to compare detection of macrometastases, micrometastases and submicrometastases in sentinel lymph nodes using hematoxylin-eosin examination and immunohistochemical examination according to the Czech Pathological Society guidelines. Between January 1st 2006 and December 31 st 2008 there were operated 173 patients with 174 breast cancer tumors at the Department of Surgery Pardubice. Based on size of metastases patients were stratified into groups according the American Joint Commitee on Cancer (AJCC). Totally, 173 patients underwent sentinel lymph node biopsy. One patient had bilateral tumor. There were performed 174 breast surgeries with sentinel lymph node biopsy. Using IHC examination there were found additional 15 (8,6%) patients with submicrometastases in...
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Perioperative prognostic factors in breast cancer
Černá, Monika ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Šiller, Jiří (referee) ; Jandík, Pavel (referee)
Introduction: Breast cancer still remains the most common malignancy in women and its incidence is slowly increasing. A marked reduction of mortality has been achieved in the last 10 years thanks to modern diagnostic methods, mammary screening, and comprehensive and targeted cancer therapy. Modern diagnostic capabilities not only allow early diagnosis of a primary tumor lesion and precise determination of its biological nature before commencing treatment, but they also enable early diagnosis of local and regional recidives, including diagnosis of metastases in distant organs. In addition to clinical examination, conventional and complementary imaging examinations and tumor markers our objective was to determine the importance and use of growth factors in relation to the overall prognosis. The growth factors physiologically act already during the ontogenetic period when they control cell growth, proliferation, differentiation and apoptotic processes. It is known that they take part in the tumor growth processes which are characterized by autonomous behavior, increased proliferative activity, distinct differentiation activity and reduced apoptosis. Growth factors work as autoregulation factors in the neoplastic process as well as through their paracrine effects mediated by more or less specific receptors....
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New Possibilities of Prevention and Monitoring of Breast Cancer
Hosnedlová, Andrea ; Třeška, Vladislav (advisor) ; Jandík, Pavel (referee) ; Gaťek, Jiří (referee)
Introduction: Breast cancer is one of the most common cancer in women, whose incidence rate is significantly increasing worldwide. Mortality has been reduced over the past few years, thanks to constantly improving diagnostic methods, full-scale mammography screening as well as comprehensive treatment. The success rate of treatment is known to depend on the earliness of diagnosis of breast cancer. Therefore, the scientists endeavour to find and optimize laboratory diagnosis of tumors using serum or tissue tumor markers. However, thus far, there is no biomarker suitable for screening or diagnosis of the early stage of breast cancer. Aim of the study: Our main goal was to study classic tumor markers and many other molecules associated with the process of carcinogenesis, namely markers of angiogenesis and lymphangiogenesis, growth factors, multifunctional proteins and proteases to assess their benefit of evaluation of tumor aggressiveness, extent of surgery, choice of the subsequent therapy and recurrence detection. A partial objective was to compare preoperative levels of these biomarkers (CEA, CA 15-3, CYFRA 21-1, TPA, TK, MonoTotal, VEGF, EGF, IGF-1, IGF-BP3, Osteopontin, Osteoprotegerin, Matrix Metalloproteinases MMP-2 and MMP-9) between a group of patients with malignant and benign breast disease....
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Complex caring for patients with ostomy
Pazderová, Eva ; Schneiderová, Michaela (advisor) ; Langrová, Eva (referee) ; Jandík, Pavel (referee)
Bachaleors thesis deals with complex care of clients with intestinal derivational stomies. In the exordium the theoretical knowledge to given questions is introduced, the empirical part was processed upon an identified and evaluated data of the realized research. The quality of care of multidisciplinar medical teams was monitored during attendance of clients with this kind of disorder. In subparameters the psychosocial support of clients with stomy was surveyed as well as the influence of restrictive factors incidental to their everyday life after stomy disposition.
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Biological activity of breast cancer
Zedníková, Ilona ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Jandík, Pavel (referee)
Structured abstract Introduction: Breast cancer is the most common malignant disease in women and represents a worldwide problem. By using up-to-date diagnostics methods, mammography screening as well as complex treatment, mortality was substantially reduced. However, the incidence of disease is constantly growing in a moderate way. The struggle against this disease has several levels, such as prevention, primary tumor therapy as well as solution of recurrent disease or generalization of this. Therefore, it is very significant to evaluate prognosis on the basis of biological characteristics of tumor and to determine the right individual therapy in each patient. Aim of the study: Our aim was to determine a group of patients with malignant breast disease on the basis of biological characteristics of the tumor axillary exenteration might be omitted in if there is the presence of sentinel lymph node metastasis, which can reduce morbidity connected with this surgery without worsening prognosis. Group and methodology: The research project lasted from June 2012 to June 2015. It was an introspective randomized study where the main investigated group was made up of women with primarily surgically treated mammary cancer who underwent sentinel lymph node biopsy (SNB) within surgery. These were divided into three...
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New Possibilities of Prevention and Monitoring of Breast Cancer
Hosnedlová, Andrea ; Třeška, Vladislav (advisor) ; Jandík, Pavel (referee) ; Gaťek, Jiří (referee)
Introduction: Breast cancer is one of the most common cancer in women, whose incidence rate is significantly increasing worldwide. Mortality has been reduced over the past few years, thanks to constantly improving diagnostic methods, full-scale mammography screening as well as comprehensive treatment. The success rate of treatment is known to depend on the earliness of diagnosis of breast cancer. Therefore, the scientists endeavour to find and optimize laboratory diagnosis of tumors using serum or tissue tumor markers. However, thus far, there is no biomarker suitable for screening or diagnosis of the early stage of breast cancer. Aim of the study: Our main goal was to study classic tumor markers and many other molecules associated with the process of carcinogenesis, namely markers of angiogenesis and lymphangiogenesis, growth factors, multifunctional proteins and proteases to assess their benefit of evaluation of tumor aggressiveness, extent of surgery, choice of the subsequent therapy and recurrence detection. A partial objective was to compare preoperative levels of these biomarkers (CEA, CA 15-3, CYFRA 21-1, TPA, TK, MonoTotal, VEGF, EGF, IGF-1, IGF-BP3, Osteopontin, Osteoprotegerin, Matrix Metalloproteinases MMP-2 and MMP-9) between a group of patients with malignant and benign breast disease....
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Biological activity of breast cancer
Zedníková, Ilona ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Jandík, Pavel (referee)
Structured abstract Introduction: Breast cancer is the most common malignant disease in women and represents a worldwide problem. By using up-to-date diagnostics methods, mammography screening as well as complex treatment, mortality was substantially reduced. However, the incidence of disease is constantly growing in a moderate way. The struggle against this disease has several levels, such as prevention, primary tumor therapy as well as solution of recurrent disease or generalization of this. Therefore, it is very significant to evaluate prognosis on the basis of biological characteristics of tumor and to determine the right individual therapy in each patient. Aim of the study: Our aim was to determine a group of patients with malignant breast disease on the basis of biological characteristics of the tumor axillary exenteration might be omitted in if there is the presence of sentinel lymph node metastasis, which can reduce morbidity connected with this surgery without worsening prognosis. Group and methodology: The research project lasted from June 2012 to June 2015. It was an introspective randomized study where the main investigated group was made up of women with primarily surgically treated mammary cancer who underwent sentinel lymph node biopsy (SNB) within surgery. These were divided into three...
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Perioperative prognostic factors in breast cancer
Černá, Monika ; Třeška, Vladislav (advisor) ; Gaťek, Jiří (referee) ; Šiller, Jiří (referee) ; Jandík, Pavel (referee)
Introduction: Breast cancer still remains the most common malignancy in women and its incidence is slowly increasing. A marked reduction of mortality has been achieved in the last 10 years thanks to modern diagnostic methods, mammary screening, and comprehensive and targeted cancer therapy. Modern diagnostic capabilities not only allow early diagnosis of a primary tumor lesion and precise determination of its biological nature before commencing treatment, but they also enable early diagnosis of local and regional recidives, including diagnosis of metastases in distant organs. In addition to clinical examination, conventional and complementary imaging examinations and tumor markers our objective was to determine the importance and use of growth factors in relation to the overall prognosis. The growth factors physiologically act already during the ontogenetic period when they control cell growth, proliferation, differentiation and apoptotic processes. It is known that they take part in the tumor growth processes which are characterized by autonomous behavior, increased proliferative activity, distinct differentiation activity and reduced apoptosis. Growth factors work as autoregulation factors in the neoplastic process as well as through their paracrine effects mediated by more or less specific receptors....
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Significance of subclassification of sentinel lymph involvement in breast cancer for following surgical treatment
Červinka, Vladimír ; Jandík, Pavel (advisor) ; Schützner, Jan (referee) ; Fait, Vuk (referee)
Summary of histopathological analysis Sentinel lymph node biopsy is relatively new staging method in breast cancer women .Sentinel lymph nodes are assessed by hematoxylin eosin (HE) and by immunohistochemistry (IHC). The reason of the histopathological analysis of sentinel lymph nodes was to compare histological work up by HE with histological work up by IHC and based on this comparisone find if immunohistochemical examination of sentinel lymph nodes brings benefit to the patients or not. The goals of the histopathological analysis were to compare detection of macrometastases, micrometastases and submicrometastases in sentinel lymph nodes using hematoxylin-eosin examination and immunohistochemical examination according to the Czech Pathological Society guidelines. Between January 1st 2006 and December 31 st 2008 there were operated 173 patients with 174 breast cancer tumors at the Department of Surgery Pardubice. Based on size of metastases patients were stratified into groups according the American Joint Commitee on Cancer (AJCC). Totally, 173 patients underwent sentinel lymph node biopsy. One patient had bilateral tumor. There were performed 174 breast surgeries with sentinel lymph node biopsy. Using IHC examination there were found additional 15 (8,6%) patients with submicrometastases in...
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Comparative study of nursing in different surgical approaches in breast cancer women
Hošková, Blanka ; Červinka, Vladimír (advisor) ; Jandík, Pavel (referee) ; Tůmová, Andrea (referee)
ANNOTATION: Author: Blanka Hošková Institution: Surgery Department, Pardubice General Hospital. Title: Comparative study of nursing in different surgical approaches in breast cancer women Supervisor: Vladimír Červinka, M.D. Mgr. Jana Kučerová Number of pages: Numer of attachments : The year of finalizing 2008-04-06 Key words: brest cancer, sentinel lymph node biopsy, nursing after mastectomy, axillary lymph node dissection The aim of the bachelors work was to assess all information about breast cancer, characterized this disease, defined symptomatology, describe examination process, screening, chances of the treatment and prevention.. Our goal was to assess new trends in surgical treatment, nursing and implementation of these techniques into the praxis. Reasearch is to give information about average hospitalization time after particular types of procedures, about the lenght of insertion of the Redon drain, postoperative complications, postoperative inflammatory complications, postmastectomy pain syndrom and lymphedema. There are enclosed two casuistics: the first one - about the pacient who underwent sentinel lymph node biopsy and second one about the patient who underwent axillary dissection. This study informs about the possibilities and advantages of the new surgical approaches from nursing point of view...
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