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Autoimmune thyroiditis in children and the role of simultaneous Helicobacter pylori infection
Pomahačová, Renata ; Sýkora, Josef (advisor) ; Hníková, Olga (referee) ; Kalvachová, Božena (referee)
1. Summary The first aim of our study was to find out the present occurence of H. pylori infection in a group of children with juvenile lymphocytic thyroiditis (JLT) and to compare with the prevalence of this infection in a group of healthy children of the same age. The group of patients with JLT included 199 children (range 0-18 years). H. pylori infection was confirmed in 15 patients (7,5%) by a non-invasive diagnostic test of H. pylori antigen positivity in stools by the ELISA test using monoclonal antibodies (Amplified IDEIQA HpStAR ELISA, DakoCytomation, Glostrup, Denmark). This H.pylori positive group included 14 girls and 1 boy aged 11,2 ±2,3. 6 children had hypofunction of the thyroid gland, in 3 children was established the atrophic form of the thyroiditis with severe hypothyroidism with presence of myxoedema, the other children suffered from the hypertrophic form of the thyroiditis. 7 subjects underwent gastroscopy which confirmed chronic active gastritis. Only 3 children had gastrointestinal symptoms caused by H. pylori infection, the other children were asymptomatic. This finding confirms common information about asymptomatic development of H. pylori infection in children in 90% of cases. The control group included 1545 asymptomatic healthy children in range of 0-15 years of the same geographic...
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Auxological aspects in patients with congenital adrenal hyperplasia.
Petzoldová, Barbora ; Sedlak, Petr (advisor) ; Hníková, Olga (referee)
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common inherited endocrinopathy. This disorder is associated with many complications caused either by illness itself or inadequate treatment. The late consequence of this disorder is a reduced final height. Absences of cortisol, androgen excess, with or without salt wasting, virilization of external genitalia in new-born girls are main findings. Androgen excess causes virilization in girls, accelerated bone maturation and early epiphyseal fusion in both sexes. CAH patients are dependent on lifelong treatment with oral glucocorticoids. Growth retardation and obesity are common side effects resulting from glucocorticoid use. The aim of this thesis was to analyse the success of obtaining a final height that is within a genetic potential regarding to treatment compliance. The other objective was the analysis of auxological profile of CAH patients. This study was mainly focused on the analysis of body height, linear proportionality, the weight parameters, body composition, body fat distribution, skeletal robusticity and body structure. In this study we performed anthropometric examination of 30 CAH patients. 25 of them had completed growth (age: 16,4 to 44,5 years), 12 woman and 11 men and 2 men with karyotype 46XX....
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Mass neonatal screening from dry blood spot
Balunová, Michala ; Hníková, Olga (advisor)
The aim of mass neonatal screening from dry blood spot is to systemically and actively identify specific congenital disorders in all the newborns. Inborn conditions being screened are either without clinical symptoms in early postnatal period, or the symptoms are easily overlooked. The onset of symptoms is often past the critical time when clinical damage was reversible. Mass neonatal screening enables early diagnostics and intervention. Screening prevents morbidity associated with these conditions, especially concerning central nervous system. It avoids the manifestations of acute crises, which may leed to the death of patients. Mass newborn screening has been a very successful preventive program to be initiated in the Czech Republic in 1975. Since 1.10. 2009 the neonatal screening in the Czech Republic encompasses these conditions: phenylketonuria/hyperphenylalaninemia, congenital hypothyroidism, congenital adrenal hyperplasia, cystic fibrosis, maple syrup urine disease, medium-chain acyl-CoA dehydrogenase deficiency, very long-chain acyl-CoA dehydrogenase deficiency, long-chain hydroxyacyl-CoA dehydrogenase deficiency, carnitine palmitoyl transferase deficiency I, cernitine palmitoyl transferase deficiency II, carnitine/acylcarnitine translocase deficiency, glutaric aciduria I and isovaleric acidemia....
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Autoimmune thyroiditis in children and the role of simultaneous Helicobacter pylori infection
Pomahačová, Renata ; Sýkora, Josef (advisor) ; Hníková, Olga (referee) ; Kalvachová, Božena (referee)
1. Summary The first aim of our study was to find out the present occurence of H. pylori infection in a group of children with juvenile lymphocytic thyroiditis (JLT) and to compare with the prevalence of this infection in a group of healthy children of the same age. The group of patients with JLT included 199 children (range 0-18 years). H. pylori infection was confirmed in 15 patients (7,5%) by a non-invasive diagnostic test of H. pylori antigen positivity in stools by the ELISA test using monoclonal antibodies (Amplified IDEIQA HpStAR ELISA, DakoCytomation, Glostrup, Denmark). This H.pylori positive group included 14 girls and 1 boy aged 11,2 ±2,3. 6 children had hypofunction of the thyroid gland, in 3 children was established the atrophic form of the thyroiditis with severe hypothyroidism with presence of myxoedema, the other children suffered from the hypertrophic form of the thyroiditis. 7 subjects underwent gastroscopy which confirmed chronic active gastritis. Only 3 children had gastrointestinal symptoms caused by H. pylori infection, the other children were asymptomatic. This finding confirms common information about asymptomatic development of H. pylori infection in children in 90% of cases. The control group included 1545 asymptomatic healthy children in range of 0-15 years of the same geographic...
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