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Coronary atherosclerosis imaging using CT coronary angiography in patients with high risk of coronary heart disease
Baxa, Jan ; Ferda, Jiří (advisor) ; Vymazal, Josef (referee) ; Mechl, Marek (referee)
Coronary atherosclerosis imaging using CT coronary angiography in patients with high risk of coronary heart disease Coronary heart disease (CHD) belongs to most frequent disorders and in industrial countries is responsible for most deaths in population. The costs of treatment of the clinical manifested CHD are high, so there is tendency to detect this disease in early phase and ideally before development of clinical symptoms. Aim of our study was to evaluate the value of coronary CT angiography (CCTA) in detecting of coronary atherosclerosis in early (preclinical) phase. Our goals were estimation of prevalence of atherosclerosis in group, influence of main risk factors on grade and character of atherosclerotic changes. In follow-up we concerned on occurrence of cardiac events. 205 patients with increased cardiovascular risk underwent CCTA using dual-source CT. Coronary findings were analyzed by character of atherosclerotic changes and degree of event. stenosis. Statistical evaluation of influence of risk factors was made using the odds ratio. The statistically important differences were tested between subgroup of type 2 diabetics and non-diabetics. All patients were under follow-up for two years. Overall prevalence of atherosclerosis in analyzed group was 73 %, calcified lesions were found in 63.9 %...
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Detection and characterization of hepatocellular liver lesions by using MRI with hepatospecific contrast agent Gd-EOB-DTPA
Mrklovský, Milan ; Žižka, Jan (advisor) ; Mechl, Marek (referee) ; Ferda, Jiří (referee)
Detection and characterization of hepatocellular liver lesions by using MRI with hepatospecific contrast agent Gd-EOB-DTPA Aim: To prospectively compare contrast properties of extracelullar (gadobutrol) and hepatospecific (gadoxetic acid) contrast agents in upper abdominal MRI studies. To prospectively evaluate the possibilities of detection and characterization of hepatocellular liver lesions by means of MRI using hepatospecific contrast agent Gd-EOB-DTPA. Materials and methods: Standardized (0,1 ml/kg) dose of gadobutrol (56 subjects) and gadoxetic acid (51 subjects) was administered intravenously by MRI-compatible injector at 2 ml/s, followed by 20 ml saline flush. MR signal intensity changes (SIC) between precontrast scans and arterial phase, portal venous phase, equilibrium, and delayed scans at 10 and 20 minutes were measured in abdominal aorta, portal vein, common bile duct, liver, and spleen. Mean SIC values for gadobutrol and gadoxetic acid were compared by a two-sample t-test with p-value < 0,05 considered significant. A total of 78 subjects with known arterial hypervascularized liver lesion (other than haemangioma) were examined on MRI with administration of liver specific contrast agent Gd-EOB-DTPA. All studies were performed before and after contrast agent injection in arterial, portal...
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Composition analysis of urinary calculi with dual-energy computed tomography
Vondráková, Alena ; Ferda, Jiří (advisor) ; Mechl, Marek (referee) ; Ungermann, Leoš (referee)
Composition analysis of urinary calculi with dual-energy computed tomography Urolithiasis is among lifestyle diseases. Question the timely and accurate diagnosis is still current. Therapeutic approach in dealing with kidney stones depends on the particular chemical composition of urinary stone. Since the end of the 20th century as a new diagnostic option in the problems of urolithiasis exploring the possibility of using techniques of DECT, which now brings the possibility of the material characteristics of tissues in vivo. The aim of the present study was to assess the accuracy of chemical analysis stone disease DECT correlation of the results with laboratory chemical analysis of urolithiasis. The research sample of patients with urolithiasis became of the 70 individuals who underwent examination using DECT focusing on the chemical analysis of urinary calculi in vivo. Subsequently, analysis was made of laboratory extracted urolithiasis in all these patients. With regard to the distribution of urolithiasis into 4 main types according to the chemical composition of the stone was then assessed compliance DECT and laboratory methods. Consensus of both analytical methods were investigated on a small set of blind investigated calculi of known chemical composition ex vivo. The main outcome of this work is...
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Imaging Methods in the Evaluation of the Effects of Liver Tumours Therapy
Ludvík, Jaroslav ; Ferda, Jiří (advisor) ; Mechl, Marek (referee) ; Ungermann, Leoš (referee)
Imaging methods in the evaluation of the effects of liver tumours therapy Objectives. Liver resection is the only potential curative therapy of liver tumours today. Small future liver remnant volume (FLRV) after the resection is a limitation with the risk of hepatic failure. The increase of FLRV after portal vein embolization (PVE) is often inadequate. PVE with contralateral application of hematopoietic stem cells (HCS) can facilitate the regeneration of liver. CT liver volumetry enables to evaluate the increase of FLRV and the safety of liver resection. By automatic CT liver volumetry it is possible to determine the size of liver segments, the volume of the tumour and to make a 3D reconstruction of liver vessels. The aim of the first prospective study was to verify the effect of HSC on the liver growth. The impact of both HSC derived from peripheral blood and from bone marrow was compared. The second, retrospective study aimed to evaluate the accuracy and the speed of the automatic CT liver volumetry in comparison to manual CT volumetry. Material and methods. 20 patients (the group I) underwent PVE with the contralateral application of HSC in the 1st study. In the control group II (n = 20) was performed PVE only. By the manual CT volumetry (Syngo Volume, Siemens Healthineers, Forchheim, Germany)...
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Complex Preoperative Brain Tumor Imaging
Tupý, Radek ; Ferda, Jiří (advisor) ; Vymazal, Josef (referee) ; Tüdös, Zbyněk (referee)
Title Complex preoperative brain tumor imaging Abstract The differentiation of glioblastoma, metastases and brain lymphoma using modern diagnostic imaging methods has a major impact on the strategy of further diagnostic examinations and treatment. In a group of 67 patients with glioblastoma and 31 with cerebral metastasis, the ability to differentiate them according to the evaluation of perfusion parameters changes in peritumoral white matter by T1 dynamic post-contrast magnetic resonance imaging was verified, with the positive predictive value in glioblastoma detection up to 91%. In a group of 36 brain lymphoma patients the importance of imaging submodalities and contribution of a complex magnetic resonance imaging protocol to detect lymphoma up to 80% were evaluated. Key words brain, glioblastoma, lymphoma, magnetic resonance imaging, neoplasm metastasis
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Imaging Methods in the Evaluation of the Effects of Liver Tumours Therapy
Ludvík, Jaroslav ; Ferda, Jiří (advisor) ; Mechl, Marek (referee) ; Ungermann, Leoš (referee)
Imaging methods in the evaluation of the effects of liver tumours therapy Objectives. Liver resection is the only potential curative therapy of liver tumours today. Small future liver remnant volume (FLRV) after the resection is a limitation with the risk of hepatic failure. The increase of FLRV after portal vein embolization (PVE) is often inadequate. PVE with contralateral application of hematopoietic stem cells (HCS) can facilitate the regeneration of liver. CT liver volumetry enables to evaluate the increase of FLRV and the safety of liver resection. By automatic CT liver volumetry it is possible to determine the size of liver segments, the volume of the tumour and to make a 3D reconstruction of liver vessels. The aim of the first prospective study was to verify the effect of HSC on the liver growth. The impact of both HSC derived from peripheral blood and from bone marrow was compared. The second, retrospective study aimed to evaluate the accuracy and the speed of the automatic CT liver volumetry in comparison to manual CT volumetry. Material and methods. 20 patients (the group I) underwent PVE with the contralateral application of HSC in the 1st study. In the control group II (n = 20) was performed PVE only. By the manual CT volumetry (Syngo Volume, Siemens Healthineers, Forchheim, Germany)...
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Complex Preoperative Brain Tumor Imaging
Tupý, Radek ; Ferda, Jiří (advisor) ; Vymazal, Josef (referee) ; Tüdös, Zbyněk (referee)
Title Complex preoperative brain tumor imaging Abstract The differentiation of glioblastoma, metastases and brain lymphoma using modern diagnostic imaging methods has a major impact on the strategy of further diagnostic examinations and treatment. In a group of 67 patients with glioblastoma and 31 with cerebral metastasis, the ability to differentiate them according to the evaluation of perfusion parameters changes in peritumoral white matter by T1 dynamic post-contrast magnetic resonance imaging was verified, with the positive predictive value in glioblastoma detection up to 91%. In a group of 36 brain lymphoma patients the importance of imaging submodalities and contribution of a complex magnetic resonance imaging protocol to detect lymphoma up to 80% were evaluated. Key words brain, glioblastoma, lymphoma, magnetic resonance imaging, neoplasm metastasis
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Comparison of CT (power) and standard venous port systems in long-term central venous access in outpatients
Hájek, Jan ; Krajina, Antonín (advisor) ; Ferda, Jiří (referee) ; Charvát, Jiří (referee)
Summary: Comparison of CT (power) and standard venous port systems in long-term central venous access in outpatients. The aim of our study was to evaluate benefit of use of portsystems during contrast enhanced CT examinations. We studied implantation of power port systems in short and middle time period and also compared the procedure to literature informations. We also studied benefit of power port implantation procedure done under sonographic and fluoroscopic navigation. Materials and methods: There were collected patients of two cooperating departments of interventional radiology. All our patients included in the study had implanted power port systems, the procedure was done by sonographic and fluoroscopic control. We studied periprocedural and late complications of the procedure. We also studied benefit of the power port for contrast enhanced CT follow up during oncologic therapy and frequency of port using by medical staff. We studied perception of implanted power port in our patients in their daily life. Results: The primary technical success of the procedure was 100 % and we had no postprocedural pneumothorax observed. The technique of implantation of ports and power ports is the same. The average follow up in our study is 291,5 days (2-294 days). Five patients died in follow up period 2-594 days....
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Non invasive assessment of pulmonary hypertension on chest radiograph and non contrast CT
Brožík, Jan ; Eliáš, Pavel (advisor) ; Ferda, Jiří (referee) ; Heřman, Miroslav (referee)
Non invasive assessment of pulmonary hypertension on chest radiograph and non contrast CT Objective: To evaluate relationship between selected qualitative and quantitative parameters and mean pulmonary artery pressure (mPAP) in patients with chronic pulmonary disease. To assess, whether a radiologist with use of a set of measurements in combination with positivity of qualitative findings is able reliably predict presence of pulmonary hypertension (PH) on chest radiographs (CXR) and High-resolution CT (HRCT) of lungs. To examine reproducibility of the used method by assessment of interobserver agreement between radiologists in diagnosing pulmonary hypertsension. Materials and Methods:53 individuals with chronic lung disease underwent right heart cathetrisation, CXR and HRCT. 30 patients had PH confirmed. CXRs and HRCTs were reviewed independetly by three radiologist who besides evaluation of findings stated whether PH is present. Relation between relevant parameters and mPAP, agreement between radiologists and real presence of PH were assessed. Results: The strongest correlation on CXR was found between mPAP and ratio of right descending pulmonary artery width and the left main bronchus (r = 0,256650, p = 0,023362) and right descending pulmonary artery width (r = 0,188897, p = 0,002048). The...
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Detection and characterization of hepatocellular liver lesions by using MRI with hepatospecific contrast agent Gd-EOB-DTPA
Mrklovský, Milan ; Žižka, Jan (advisor) ; Mechl, Marek (referee) ; Ferda, Jiří (referee)
Detection and characterization of hepatocellular liver lesions by using MRI with hepatospecific contrast agent Gd-EOB-DTPA Aim: To prospectively compare contrast properties of extracelullar (gadobutrol) and hepatospecific (gadoxetic acid) contrast agents in upper abdominal MRI studies. To prospectively evaluate the possibilities of detection and characterization of hepatocellular liver lesions by means of MRI using hepatospecific contrast agent Gd-EOB-DTPA. Materials and methods: Standardized (0,1 ml/kg) dose of gadobutrol (56 subjects) and gadoxetic acid (51 subjects) was administered intravenously by MRI-compatible injector at 2 ml/s, followed by 20 ml saline flush. MR signal intensity changes (SIC) between precontrast scans and arterial phase, portal venous phase, equilibrium, and delayed scans at 10 and 20 minutes were measured in abdominal aorta, portal vein, common bile duct, liver, and spleen. Mean SIC values for gadobutrol and gadoxetic acid were compared by a two-sample t-test with p-value < 0,05 considered significant. A total of 78 subjects with known arterial hypervascularized liver lesion (other than haemangioma) were examined on MRI with administration of liver specific contrast agent Gd-EOB-DTPA. All studies were performed before and after contrast agent injection in arterial, portal...
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