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Depression development and social inequalities during the period after COVID-19 outbreak in the population aged 50 years and more
Dolečková, Kateřina ; Dzúrová, Dagmar (advisor) ; Dalecká, Andrea (referee)
Kateřina Dolečková: Vznik deprese a sociální nerovnosti v období po vypuknutí pandemie COVID-19 u populace ve věku 50 let a více Depression development and social inequalities during the period after COVID-19 outbreak in the population aged 50 years and more Abstract The COVID-19 pandemic had a major impact on health of many individuals, in particular the elderly. The aim of this thesis was to investigate the development of depression following the outbreak of COVID-19 pandemic in a European population aged 50 years and more in context of social inequalities. A total of 11 648 SHARE study participants were analyzed (55,2 % female, mean age 69,5 years). The development of depression was examined based on the occurrence of respondents' subjective feelings of sadness or depression after the outbreak of COVID-19 pandemic, compared to the occurrence of these feelings before the pandemic outbreak. Significant factors influencing the development of depression, which were identified using the method of binary logistic regression, included sociodemographic characteristics, health and healthcare-related indicators, as well as social indicators. The development of depression varied also based on the respondent's country of residence, which was determined by the multilevel modelling. Key words: mental health,...
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Cathepsins B of the bird schistosome, Trichobilharzia regenti
Dolečková, Kateřina ; Horák, Petr (advisor) ; Grevelding, Christoph (referee) ; Horn, Martin (referee)
1. Overview Schistosomes have achieved first position among parasitic helminths, because some of them are the etiological agents of a serious human parasitic disease, schistosomiasis, which affects over 200 million people in tropical and subtropical countries (WHO, 2001). Other schistosomatids, such as the bird flukes of the genus Trichobilharzia, have also implications for human health. Although they can mature only in specific hosts (birds), their invasive larvae - cercariae - are able to penetrate also human skin due to chemical signals similar to those present on bird skin (Haas and van de Roemer 1998). Repeated infections result in an inflammatory reaction of the skin called cercarial dermatitis. Due to the increasing number of outbreaks all around the world, cercarial dermatitis is cons disease (Kolářová 2007idered as re-emerging ; Larsen et al. 2004). Among schistosomes, Trichobilharzia regenti is the only species described so far having a unique migration route within vertebrate hosts: after penetration of the skin, the invasive larvae enter peripheral nerves and continue via the spinal cord and central nervous system to the nasal cavity of birds, causing neuromotor disorders or paralyses of birds and even experimental mammals (Hrádková...
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Cathepsins B of the bird schistosome, Trichobilharzia regenti
Dolečková, Kateřina ; Horák, Petr (advisor) ; Grevelding, Christoph (referee) ; Horn, Martin (referee)
1. Overview Schistosomes have achieved first position among parasitic helminths, because some of them are the etiological agents of a serious human parasitic disease, schistosomiasis, which affects over 200 million people in tropical and subtropical countries (WHO, 2001). Other schistosomatids, such as the bird flukes of the genus Trichobilharzia, have also implications for human health. Although they can mature only in specific hosts (birds), their invasive larvae - cercariae - are able to penetrate also human skin due to chemical signals similar to those present on bird skin (Haas and van de Roemer 1998). Repeated infections result in an inflammatory reaction of the skin called cercarial dermatitis. Due to the increasing number of outbreaks all around the world, cercarial dermatitis is cons disease (Kolářová 2007idered as re-emerging ; Larsen et al. 2004). Among schistosomes, Trichobilharzia regenti is the only species described so far having a unique migration route within vertebrate hosts: after penetration of the skin, the invasive larvae enter peripheral nerves and continue via the spinal cord and central nervous system to the nasal cavity of birds, causing neuromotor disorders or paralyses of birds and even experimental mammals (Hrádková...
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