|
|
Application potential of screening in vitro toxicological assays in qualitative risk assessment of nanomaterials
Závodná, Táňa ; Topinka, Jan ; Danihelka, J.
Undeniable benefits of engineered nanomaterials might be discredited by their potential enhanced or unexpected toxicity arising from nano-specific properties and behavior. An analysis of the applicability of the traditional chemical risk assessment approach in nanomaterials revealed high levels of uncertainty in both hazard characterization and exposure assessment due to the lack of relevant validated methods and reliable data. This indicates the limited capability of the conventional risk assessment approach to ensure the safe use of nanomaterials. Based on the identified uncertainties, the control banding approach was proposed as a suitable tool for preliminary qualitative risk assessment of nanomaterials in occupational settings. Control banding categorizes hazard and exposure into levels referred to as bands. The combination of the hazard and exposure bands results in a risk band determining the necessary degree of control and regulatory measures. To decrease the number of cases where, based on the precautionary principle, unavailable experimental or field data would lead to the assignment to the highest hazard category requiring costly exposure control, screening evaluation of nanomaterial toxicity was proposed as an additional decision criterion. For this purpose, a battery of in vitro toxicological assays enabling screening evaluation of potential toxic effects of NMs was proposed. The assays evaluate endpoints covering basic toxic effects of substances (cytotoxicity, genotoxicity), as well as known nonspecific mechanisms of toxicity typical for nanomaterials (oxidative stress, inflammation). The proposed risk management strategy is intended to assist small and medium-sized enterprises to implement adequate measures to ensure employee safety.
|
|
|
Modelling of terrain and its modifications
Danihelka, Jiří ; Kolingerová, Ivana (advisor) ; Vaněček, Pavel (referee)
This thesis is about intuitive terrain modeling for needs of computer games. The thesis is searching for a method of terrain modeling that will be easy for people with lack of experience. The method also should be able to allow powerful modeling techniques for professionals game creators. The thesis debate about choosing appropriate method and compare different methods between each other. Selected is the method of moving control points of Bezier patches. The thesis presents a program Terrain Editor that was created as part of the thesis. The program implements selected method and demonstrates its use in practice.
|
|
|
Modelling of terrain and its modifications
Danihelka, Jiří ; Vaněček, Pavel (referee) ; Kolingerová, Ivana (advisor)
This thesis is about intuitive terrain modeling for needs of computer games. The thesis is searching for a method of terrain modeling that will be easy for people with lack of experience. The method also should be able to allow powerful modeling techniques for professionals game creators. The thesis debate about choosing appropriate method and compare different methods between each other. Selected is the method of moving control points of Bezier patches. The thesis presents a program Terrain Editor that was created as part of the thesis. The program implements selected method and demonstrates its use in practice.
|
|
|
Visualization of trajectories of cars estimated using mobile phones signal levels
Danihelka, Jiří ; Bureš, Tomáš (referee) ; Kalibera, Tomáš (advisor)
This thesis covers the issue of location and trajectory displaying of a car or another object which were determined only on the basis of cell phone signal levels. Localization algorithms, information about the transmitter's positions and a signal propagation model are used to determine the location. A part of the thesis is the Guesstor Client program that displays the results of localization algorithms in a well arranged graphic form, makes it possible to compare the accuracy of different localization methods and allows us to follow the trajectory of automobiles in real time. The Guesstor Client program connects via a remote method invocation protocol the program Guesstor Server which contains the location algorithms and manages the measurements database.
|
|
| |
|
| |
|
|
Diverzita vegetačních typů a recentních pylových spekter západních Sajan, Sibiř
Lučeničová, B. ; Kuneš, P. ; Jankovská, Vlasta ; Svobodová, Helena ; Chytrý, M. ; Danihelka, J. ; Ermakov, N. ; Hájek, M. ; Hájková, P. ; Havlová, Marie ; Kočí, M. ; Kubešová, S. ; Lustyk, P. ; Otýpková, Z. ; Roleček, J. ; Šmarda, P. ; Valachovič, M.
Comparison of recent pollen spectrum and the vegetation composition (Sayan, Siberia).
|
guest ::
RSS feed.