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Systematic lupus erythematosus and antiphospholipid syndrome - importance for gravidity
Kešeláková, Katarína ; Andělová, Kateřina (advisor)
This thesis deals with pregnancy complicated by the presence of systemic rheumatic disease, systemic lupus erythematosus. Further analyzes and antiphospholipid syndrome in pregnancy, which can be separately, when we talk about the primary antiphospholipid syndrome, or may be associated with a magnifying glass to the system - secondary antiphospholipid syndrome. The work seeks to provide an overview of new knowledge about diagnosis and treatment, but most focus on the relationship of these units to pregnancy, development of the fetus, birth and postpartum complications and also the question of how pregnancy affects theactivity systemic lupus erythematosus
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Glucose-metabolism pathology during pregnancy
Lišková, Michala ; Andělová, Kateřina (advisor)
Pregnancy of patients with DM is risk. Mother may be threatened by the development of acute and chronic complications of diabetes, hypertension, frequent occurrence of infectious diseases and maternal mortality. Risks for the fetus are premature birth or abortion, diabetic embryopathy, including congenital malformations, and diabetic fetopathy with fetal macrosomia and postnatal hypoglycaemia. The risk for later development of diabetes in children of diabetic mothers is 1.3%. The pre-conception care is insist on planning pregnancy to term of good compensation. Diabetes care in pregnancy include insulin therapy or insulin's pump. Diet is not different from the diet before pregnancy, it is possible higher energy intake in the 2nd and 3 trimester. The most serious complications of pregnancy with DM consequences for the fetus and mother are diabetic retinopathy and diabetic nephropathy. Diabetic nephropathy (DN) develops on the basis of protein glycation glomerulus basement membrane, other factors are hypertension and hyperfiltration. Creatinine clearance less than 125 micromol / l diastolic pressure below 85 mm Hg prognosis of pregnancy is good. At present pre-conception significantly altered renal function, a pregnancy is not recommended. The most common disabilities in the fetal complications as premature...
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New trends in antiphospholipid syndrome in pregnancy treatment
Kroupová, Monika ; Andělová, Kateřina (advisor)
Antiphospholipid syndrome is a systemic autoimmune disease characterised by presence of the antiphospholipid antibodies in serum. The diagnosis of APS including aPL measured in solid-phase immunoassays (ELISA) as anticardiolipin antibodies or detected in phospholipid dependent clotting tests as lupus anticoagulans. Positiv APS is characterised by prolonged coagulation times. In Pregnancy is APS characterised by placental insufficiency, pre-term delivery, pre-eclampsia and intrauterine growth retardation. He interferes in trofoblast growth and invasion and hampers in trofoblast function. At present is used low-molecular-weight heparin in combination with low-dose aspirin. Non-pregnant patiens with history of thrombosis are usually treated by warfarin to keep an APTT between 2-3.
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Antiphospholipid syndrome and recurrent pregnancy losses
Hoftová, Kateřina ; Andělová, Kateřina (advisor)
Antiphospholipid syndrome (APS ) is an interesting nosological unit , in which diagnosis and therapy blends many medical disciplines , most of Internal Medicine , gynecology , neurology and immunology. This is due to the diversity of symptoms to which this Autoimmune disease occurs. The basis of these symptoms are thrombosis , arterial and venous, which can affect any organ or tissue in the body. APS is not common diseases and their diagnosis is problematic. Yet it is important for this syndrome think , because it is often influenced therapeutically . It was found that the APS can cause recurrent pregnancy loss in otherwise healthy women (primary APS) in women with other diseases (secondary APS). pregnancy losses include early abortions (up to 10 weeks of gestation ) , late abortions (over 10 weeks gestation ) premature births , all at morphologically and genetically normal embryos and fetuses. At the same time APS associated with a higher incidence of pregnancy complications such as preeclampsia , placental insufficiency, intrauterine growth retardation , etc. If the APS as a cause of miscarriages identified and treated according to current technical recommendations , the result is a substantial percentage successful pregnancy.
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Thyroid dysfunction during pregnancy in women with diabetes mellitus type 1
Galandáková, Iva ; Andělová, Kateřina (advisor)
It is known, that autoimmune disease of the thyroid gland during pregnancy and postpartum period is more often in women with diabetes mellitus type 1 than in general population. Both diseases negative influence developing of the foetus and health of the mother. Therefore is important timely diagnosis and good compensation both in diabetes and in thyroid gland. Women with diabetes mellitus type 1 should plan their pregnancy and always should be the thyroid gland investigate, measurement TSH, FT4 and thyroid antibodies.
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Detention proceedings
Andělová, Kateřina ; Smolík, Petr (referee) ; Pohl, Tomáš (referee)
The detention proceedings constitutes a heavy intervention into the individual's right to personal freedom guaranteed by the Czech Constitution in a way of involuntary stay in hospital. The basis of present legal regulations of detention proceedings is necessary to see especially in the Czech Declaration of Human Rights And Freedoms (article 8, clause 6) that continues European Convention on Human Rights (article 5, clause 1e) specifying that (only) law constitutes, in which events individual may be kept in a hospital without his acceptance.
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Glucose-metabolism patology during pregnancy
Janštová, Alena ; Andělová, Kateřina (advisor)
Diabetes mellitus type 2 is a disease occurring mostly over the age of 40 years. In recent years, however, increasingly more often in younger populations , often even adolescents and children. The team is also related to the increasing prevalence of pregnant women diagnosed with pregestačným type 2 diabetes . Material fact is worsening of pregnancies among these women. The incidence of congenital malformations is 2 - 3 times higher than the normal population . prevalence of sudden intrauterine death is approximately four times higher . Perinatal mortality is comparable in both types of diabetes (2.6% of type 1 diabetes vs.3 , 7 % for type 2 diabetes ) but causes leading to fetal death are different. In Type 1 diabetes is the leading cause of perinatal mortality severe malformation of the fetus and complications related to prematurity . In type 2 diabetes dominated by sudden intrauterine fetal death . From these facts shows how important it is to you earliest detection of the disease , the importance of preconception care with emphasis on planning Parenting and provide adequate prenatal care.
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Antiphospholipid syndrome and recurrent pregnancy losses
Hoftová, Kateřina ; Andělová, Kateřina (advisor)
Antiphospholipid syndrome (APS ) is an interesting nosological unit , in which diagnosis and therapy blends many medical disciplines , most of Internal Medicine , gynecology , neurology and immunology. This is due to the diversity of symptoms to which this Autoimmune disease occurs. The basis of these symptoms are thrombosis , arterial and venous, which can affect any organ or tissue in the body. APS is not common diseases and their diagnosis is problematic. Yet it is important for this syndrome think , because it is often influenced therapeutically . It was found that the APS can cause recurrent pregnancy loss in otherwise healthy women (primary APS) in women with other diseases (secondary APS). pregnancy losses include early abortions (up to 10 weeks of gestation ) , late abortions (over 10 weeks gestation ) premature births , all at morphologically and genetically normal embryos and fetuses. At the same time APS associated with a higher incidence of pregnancy complications such as preeclampsia , placental insufficiency, intrauterine growth retardation , etc. If the APS as a cause of miscarriages identified and treated according to current technical recommendations , the result is a substantial percentage successful pregnancy.
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Insulin resistance and pregnancy
Král, Martin ; Andělová, Kateřina (advisor)
The topic of his thesis - Insulin resistance in pregnancy - I chose based on their long standing interest in issues of Diabetes and obstetrics. I was also inspired by the example of a personal life. This is a rather broad topic in terms of accumulated medical evidence. A very significant in their societal and socio-economic consequences , as described below . The topic is highly multidisciplinary and extends into the field of diabetology , gynecology and obstetrics , neonatology , etc. In their clinical consequences and medical - preventive care requires this combined approach and the participation and cooperation of the entire medical team with specialized theoretical knowledge and practical experience. There is great scope for preventive measures. Epidemiology clinical consequences of insulin resistance in pregnancy is developed in Chap. 6 (clinical implications ) . Incidence, prevalence and incidence of diseases associated with insulin resistance is ( in our country and around the Euro - American world ) is still on the rise. This thesis (as described in the next chapter ) deals with mapping issues , clinical implications and possibilities of prevention.
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