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Contribution to the Study of the Etiology and Clinical Significance of Hepatic Steatosis in the Experiment
Žaloudková, Lenka ; Živný, Pavel (advisor) ; Dlouhý, Pavel (referee) ; Teplan, Vladimír (referee)
Contribution to the study of the etiology and clinical significance of hepatic steatosis in the experiment The aim of this dissertation thesis is to elucidate and describe the influence of ursolic acid and its hepatoprotective effects on liver tissue after partial hepatectomy and the effects of this acid on lipid metabolism. It includes studies of the early phase of liver regeneration in rats with induced hepatic steatosis. The first part of the dissertation is focused on the study of liver regeneration after partial hepatectomy in rats with nutritionally induced hepatic steatosis using three experimental diets. To assess the liver regeneration, two rat models were selected, a healthy Wistar-type rat and a rat with high basal cholesterolemia, the so-called Prague hereditary hypercholesterolemic rat (PHHC). The standard model of non-alcoholic fatty liver disease (NAFLD), achieved by feeding both rat types on a high-cholesterol diet and an orotic acid diet for four weeks, confirmed the development of hepatic steatosis without signs of inflammation, necrosis or fibrotic changes. The methionine-choline deficient diet did not induce steatosis in the histological examination, although disruption of VLDL particle synthesis was found. Based on the incorporation of 3 [H]-thymidine into hepatocyte's DNA, the...
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Students education with mental disabilities and other disfunctions
Žaloudková, Lenka ; Novotný, Josef (referee) ; Zemková, Jaroslava (advisor)
Problems of education and possible socialization of individuals with mental disability to current legislation is analyzing in this desertation work. Basic ideas, characteristic of problems and development of care are mentioned in theoretical part. One of the chapters take historical moments of this problem. Practical part is made as case study, which follows partial family with handicapped child. Case study deal with involment of child to education and record his/her education to current day. Key words: mental retardation, disabilities with more defect, education, socialization, consultancy, legislation
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