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The status of women on the labour market in Czech Republic
Skopalíková, Anna ; Chytil, Zdeněk (advisor) ; Čermáková, Klára (referee)
The bachelor thesis addresses discrimination of women on the labour market in Czech Republic. Its aim is to verify hypothesises about the existence of lower mean wages of women and about the existence of discrimination of women on the labour market in Czech Republic. Oaxaca wage differential decomposition which is introduced in the theoretical part of the thesis confirmed the existence of wage differentials between the wages of men and women on the Czech labour market, in selected regions and in selected occupational fields. This confirms the hypothesis about lower mean wages of women. Oaxaca wage differentials decomposition also confirms that the wage gap can be explained in most cases up to 18 %. The second hypothesis is confirmed only partially. The discrimination of women probably exists on the labour market but it is not possible to confirm the size of it. The unexplained component of the wage gap (based on the Oaxaca decomposition) includes besides other things the discrimination coefficient. The size of this coefficient is not possible to determine. The secondary aim of the bachelor thesis is to determine the impact of individual variables on the observed wage gaps. Factors which most often influence the wage gaps are education and age.
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Methods of monitoring the profile of carnitine metabolites in urine and use in clinical diagnosis
NOVÁKOVÁ, Martina
This study deals with the profiling of carnitine metabolites in the urine of the patients with breast cancer. L-carnitine is a chemical compound that is very important for metabolism of lipids, and therefore some current research suggests that it could serve as a means for the treatment of cancer affecting various organs or tissues. The theoretical part deals with the general characteristics and a description of the L-carnitine and its effect on the body. This part is divided into chapters that summarize various information about L-carnitine and acylcarnitines, for example the metabolism, different effects in the body including a description of responses to the lack of these substances, or methods that can be used for the detection of L-carnitine levels. Methods of monitoring L-carnitine were described in detail and were compared with previously published scientific studies. The authors of scientific studies show procedures, advantages and disadvantages of the proposed methods for determining L-carnitine and acylcarnitines, that were examined in this work in detail and the method for the determination of carnitine metabolites in urine has been proposed. A brief description of the most using methods for the determination of L-carnitine metabolites by liquid chromatography mass spectroscopy (LC / MS) is done the end of this part. I have been motivated with a positive results of studies and I have used this method for analysis in my work. In the research part of my study, the sample preparation protocol and conditions for the application of the method are described. The samples from the hospital of České Budějovice have been obtained from patients with fresh breast cancer diagnosis. In this part, the treatment of samples prior to detection, the used materials, equipment, chemicals, process and device settings for analysis were described. The method provided chromatograms and mass spectra of the individual substances. Samples of patients were compared with samples of control group of healthy women, which enabled us to observe possible differences. For clarity, the graph was drawn up and it was possible to monitor only slight differences between the levels of carnitine metabolites in women with breast cancer versus the control samples. This difference is not statistically significant, especially because the variability between individuals is higher of an order of magnitude than the actual differences between the two groups. This result is due to the fact that the study has not included additional information on patients such as information about their medications or health style, the overall condition of the body, etc. A detailed study requires a systematic and very time consuming work, which was not the aim of my thesis. Liquid chromatography with hydrophilic interactions method associated with mass detector used for monitoring of L-carnitine and its metabolites profiles gives positive results, is not time consuming, affordable and above all allow suitable for the detection of substances that have been selected for my work.
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Genetic variability of dung beetles on pastures.
VRBOVÁ, Kristýna
The aim of this thesis was a research of the genetic variability of 8 populations of the dung beetle Aphodius prodromus using allozyme markers. Following population-genetic analysis were used to determine genetic structure of these populations: estimates of heterozygosity, Wright´s F- statistics, estimates of gene flow, Mantel test, PCA, Nei´s genetic distance, testing of Hardy-Weinberg equilibrium and linkage disequilibrium. The results revealed low gene flow between populations, low number of heterozygotes and disequilibrium within and between populations. Cluster analyses showed, that populations from Tichá and Rychnov nad Malší-hřbitov are genetically most different from other populations.
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Factors Affecting Metabolism of Anthelmintics
Forstová, Veronika ; Skálová, Lenka (advisor) ; Machala, Miroslav (referee) ; Chládek, Jaroslav (referee)
Nowadays, anthelmintic therapy is the main method in the fight with parasitic worms. Anthelmintics, as well as other xenobiotics, undergo structural changes by effect of biotransformation enzymes, when lipophilic substances are transformed to polar substances more easily eliminable from the organism. Generally, biological effects of metabolites and parent compound are different. Activity of biotransformation enzymes is thus the fundamental factor influencing velocity of detoxification and elimination of the compound from the body and duration of drug effect as well. Modulation of biotransformation enzymes' activities can lead to changes in pharmacokinetic parameters of drug itself as well as other xenobiotics and thus to the risk of decrease in desired effect and/or increase in adverse effects with corresponding impact on the quality of drug therapy. In addition, possible risk of drug residues' presence in animal products has to be considered in farm animals. Biotransformation of xenobiotics is affected by many physiological as well as pathological factors. These factors can be divided into inter-individual (species, gender, genetic polymorphism) and intra-individual (age, diet, medication, disease, etc.). All these factors cause wide variability in occurrence and activity of biotransformation...
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Variability of social behaviour in domestic and feral horses
ŠANDLOVÁ, Kateřina
This thesis is focused on social behaviour of horses living under feral, semi-feral and domestic conditions and its variability. This variability is represented mainly by variations in agonistic and friendly interactions among horses. Also the differences in reproductive behaviour and maternal care are included.
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Morphological variability of species \kur{Euphrasia stricta} and \kur{Euphrasia nemorosa}
HOŘČICOVÁ, Šárka
Euphrasia L. belongs to the most taxonomically complicated genera in Europe. This is caused especially by considerable similarity of majority of species, intraspecific variation and hybridization, which occurs very often in this genus. A review of the studied genera and hybridization was worked up. Morphological variation of Euphrasia stricta, Euphrasia nemorosa and morphologically intermediate populations was investigated using conventional and geometric morphometric methods. Isolation and optimalization for PCR of ITS, matK and trnT-trnL regions has been made.
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Heart rate variability in decreasing of alertness level
Strublová, Tereza ; Provazník, Ivo (referee) ; Janoušek, Oto (advisor)
Objective of this study is to familiarize with problems of measuring heart rate variability. At first there is described physiology of vascular system, then practical measuring of heart rate variability during falling asleep. At the end of this project is the statistical processing of results and comparison of the differences between heart rate variability during sleep and wakefulness.
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Practical Cognition of Nature in Teaching in primary school
TVAROHOVÁ, Eliška
The Bachelor thesis reveals the extent of practical learning about nature in the teaching of biology in primary schools and the first stage of secondary schools. Depending on the individuality of each school can be concluded that the practical activities taking place at all schools but in different degrees of the scale and frequency. It was also found the variability in student?s interests in certain topics in biology and interest in developing their own skills in relation to practical activities in activating lessons.
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