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Modelling, parameter estimation, optimisation and control of transport and reaction processes in bioreactors.
ŠTUMBAUER, Václav
With the significant potential of microalgae as a major biofuel source of the future, a considerable scientific attention is attracted towards the field of biotechnology and bioprocess engineering. Nevertheless the current photobioreactor (PBR) design methods are still too empirical. With this work I would like to promote the idea of designing a production system, such as a PBR, completely \emph{in silico}, thus allowing for the in silico optimization and optimal control determination. The thesis deals with the PBR modeling and simulation. It addresses two crucial issues in the current state-of-the-art PBR modeling. The first issue relevant to the deficiency of the currently available models - the incorrect or insufficient treatment of either the transport process modeling, the reaction modeling or the coupling between these two models. A correct treatment of both the transport and the reaction phenomena is proposed in the thesis - in the form of a unified modeling framework consisting of three interconnected parts - (i) the state system, (ii) the fluid-dynamic model and (iii) optimal control determination. The proposed model structure allows prediction of the PBR performance with respect to the modelled PBR size, geometry, operating conditions or a particular microalgae strain. The proposed unified modeling approach is applied to the case of the Couette-Taylor photobioreactor (CTBR) where it is used for the optimal control solution. The PBR represents a complex multiscale problem and especially in the case of the production scale systems, the associated computational costs are paramount. This is the second crucial issue addressed in the thesis. With respect to the computational complexity, the fluid dynamics simulation is the most costly part of the PBR simulation. To model the fluid flow with the classical CFD (Computational Fluid Dynamics) methods inside a production scale PBR leads to an enormous grid size. This usually requires a parallel implementation of the solver but in the parallelization of the classical methods lies another relevant issue - that of the amount of data the individual nodes must interchange with each other. The thesis addresses the performance relevant issues by proposing and evaluation alternative approaches to the fluid flow simulation. These approaches are more suitable to the parallel implementation than the classical methods because of their rather local character in comparison to the classical methods - namely the Lattice Boltzmann Method (LBM) for fluid flow, which is the primary focus of the thesis in this regard and alternatively also the discrete random walk based method (DRW). As the outcome of the thesis I have developed and validated a new Lagrangian general modeling approach to the transport and reaction processes in PBR - a framework based on the Lattice Boltzmann method (LBM) and the model of the Photosynthetic Factory (PSF) that models correctly the transport and reaction processes and their coupling. Further I have implemented a software prototype based on the proposed modeling approach and validated this prototype on the case of the Coutte-Taylor PBR. I have also demonstrated that the modeling approach has a significant potential from the computational costs point of view by implementing and validating the software prototype on the parallel architecture of CUDA (Compute Unified Device Architecture). The current parallel implementation is approximately 20 times faster than the unparallized one and decreases thus significantly the iteration cycle of the PBR design process.
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Men's awareness about the issue of testicular cancer.
POSPÍŠILOVÁ, Markéta
Theoretical solution Testicles are the primary male sexual organs producing testosterone. They not only make sperm but also secondary sexual features and the whole personality. We should mainly pay attention to testes in oncology because there are more occurrences of tumors with the men of younger age. These men might be very sensitive about the problems concerning sexual system and that is why the bachelor thesis deals with the issues of men's knowledge of testicular cancer. There is basic information in the thesis about organs anatomy, factor of disease, diagnostics and medical treatment. The thesis is further focused on secondary preventive measures and method of self-examination of testicles. It helps to recognize the problem in time which is in this kind of cancer very crucial. There is also mentioned the role of nurses and their instruction to men about the prevention of testicular cancer, medical care of the patient during the diagnostics, pre-operative preparation, postoperative care and other healing process. Aim of the Thesis Aim 1 Find out how much men are aware in the field of testicular cancer? Aim 2 Find out the change of behavior of men to their health after the operation of testicles? Research Question n. 1 How much men are aware about the problem in their risk age? Question n. 2 How much men are aware of self-examination methods? Question n. 3 In what field has changed the men's behavior to their health after the operation of testicles? Methodology To be able to find out necessary data, qualitative method was picked. To the collection of information was used method of half-standard interview with the questions to the concrete issues. Five respondents in a risk age were approached to the research in the case of malignant tumors origin on testicles and five respondents who had already undergone the treatment of this disease. Information was analyzed, consequently put to the categories and finally evaluated. Results Results of the research showed that men are mostly aware of the problems of testicular cancer. They usually underestimate this disease because they are not informed about the issue enough. Men usually know about the symptoms but most of them have wrong idea about the age occurrence and medical treatment. Preventive method of self-examination is for men usually unknown. Respondents who underwent operation of malignant tumor of testicles are about this method properly instructed. Frequently, according to the results, they make light the return of the disease and also do not practice the self-examination method regularly. Results also revealed that this disease is still somehow a taboo. Some respondents with the successful cure admitted that they were ashamed for this diagnoses. Conclusion The research showed us that men are not informed enough about the malignant tumor of testicles. This also confirms the fact that healthy men do not know the self-examination method. According to the results men who underwent the treatment of testicular cancer are now more informed but they usually underestimate the necessity to do the self-examination regularly. They also admitted in the interview that they were not informed enough before the disease. If they were, their health problem could have been discovered earlier and the high risk of metastasis could have been lower. For all this there is a need to increase the knowledge of the malignant testicle tumors in population which will influence the regular usage of self-examination method and it can also change the attitude of men to their health. Bachelor thesis contains pamphlet about the origin of testicular cancer. It is intended for men who are in risk age and it will be offered as a practical usage in medical facility.
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Packet Classification Algorithms
Puš, Viktor ; Lhotka,, Ladislav (referee) ; Dvořák, Václav (advisor)
Tato práce se zabývá klasifikací paketů v počítačových sítích. Klasifikace paketů je klíčovou úlohou mnoha síťových zařízení, především paketových filtrů - firewallů. Práce se tedy týká oblasti počítačové bezpečnosti. Práce je zaměřena na vysokorychlostní sítě s přenosovou rychlostí 100 Gb/s a více. V těchto případech nelze použít pro klasifikaci obecné procesory, které svým výkonem zdaleka nevyhovují požadavkům na rychlost. Proto se využívají specializované technické prostředky, především obvody ASIC a FPGA. Neméně důležitý je také samotný algoritmus klasifikace. Existuje mnoho algoritmů klasifikace paketů předpokládajících hardwarovou implementaci, přesto však tyto přístupy nejsou připraveny pro velmi rychlé sítě. Dizertační práce se proto zabývá návrhem nových algoritmů klasifikace paketů se zaměřením na vysokorychlostní implementaci ve specializovaném hardware. Je navržen algoritmus, který dělí problém klasifikace na jednodušší podproblémy. Prvním krokem je operace vyhledání nejdelšího shodného prefixu, používaná také při směrování paketů v IP sítích. Tato práce předpokládá využití některého existujícího přístupu, neboť již byly prezentovány algoritmy s dostatečnou rychlostí. Následujícím krokem je mapování nalezených prefixů na číslo pravidla. V této části práce přináší vylepšení využitím na míru vytvořené hashovací funkce. Díky použití hashovací funkce lze mapování provést v konstantním čase a využít při tom pouze jednu paměť s úzkým datovým rozhraním. Rychlost tohoto algoritmu lze určit analyticky a nezávisí na počtu pravidel ani na charakteru síťového provozu. S využitím dostupných součástek lze dosáhnout propustnosti 266 milionů paketů za sekundu. Následující tři algoritmy uvedené v této práci snižují paměťové nároky prvního algoritmu, aniž by ovlivňovaly rychlost. Druhý algoritmus snižuje velikost paměti o 11 % až 96 % v závislosti na sadě pravidel. Nevýhodu nízké stability odstraňuje třetí algoritmus, který v porovnání s prvním zmenšuje paměťové nároky o 31 % až 84 %. Čtvrtý algoritmus kombinuje třetí algoritmus se starším přístupem a díky využití několika technik zmenšuje paměťové nároky o 73 % až 99 %.
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Optimization of Gaussian Mixture Subspace Models and Related Scoring Algorithms in Speaker Verification
Glembek, Ondřej ; Brummer, Niko (referee) ; Campbell,, William (referee) ; Burget, Lukáš (advisor)
Tato práce pojednává o modelování v podprostoru parametrů směsí gaussovských rozložení pro rozpoznávání mluvčího. Práce se skládá ze tří částí. První část je věnována skórovacím metodám při použití sdružené faktorové analýzy k modelování mluvčího. Studované metody se liší převážně v tom, jak se vypořádávají s variabilitou kanálu testovacích nahrávek. Metody jsou prezentovány v souvislosti s obecnou formou funkce pravděpodobnosti pro sdruženou faktorovou analýzu a porovnány jak z hlediska přesnosti, tak i z hlediska rychlosti. Je zde prokázáno, že použití lineární aproximace pravděpodobnostní funkce dává výsledky srovnatelné se standardním vyhodnocením pravděpodobnosti při dramatickém zjednodušení matematického zápisu a tím i zvýšení rychlosti vyhodnocování. Druhá část pojednává o extrakci tzv. i-vektorů, tedy nízkodimenzionálních reprezentací nahrávek. Práce prezentuje dva přístupy ke zjednodušení extrakce. Motivací pro tuto část bylo jednak urychlení extrakce i-vektorů, jednak nasazení této úspěšné techniky na jednoduchá zařízení typu mobilní telefon, a také matematické zjednodušení umožněňující využití numerických optimalizačních metod pro diskriminativní trénování. Výsledky ukazují, že na dlouhých nahrávkách je zrychlení vykoupeno poklesem úspěšnosti rozpoznávání, avšak na krátkých nahrávkách, kde je úspěšnost rozpoznávání nízká, se rozdíly úspěšnosti stírají. Třetí část se zabývá diskriminativním trénováním v oblasti rozpoznávání mluvčího. Jsou zde shrnuty poznatky z předchozích prací zabývajících se touto problematikou. Kapitola navazuje na poznatky z předchozích dvou částí a pojednává o diskriminativním trénování parametrů extraktoru i-vektorů. Výsledky ukazují, že při klasickém trénování extraktoru a následném diskriminatviním přetrénování tyto metody zvyšují úspěšnost.
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Optimization of network flow monitoring
Žádník, Martin ; Lhotka,, Ladislav (referee) ; Matoušek, Radomil (referee) ; Sekanina, Lukáš (advisor)
The thesis deals with optimization of network flow monitoring. Flow-based network traffic processing, that is, processing packets based on some state information associated to the flows which the packets belong to, is a key enabler for a variety of network services and applications. The number of simultaneous flows increases with the growing number of new services and applications. It has become a challenge to keep a state per each flow in a network device processing high speed traffic. A flow table, a structure with flow states, must be stored in a memory hierarchy. The memory closest to the processing is known as a flow cache. Flow cache management plays an important role in terms of its effective utilization, which affects the performance of the whole system. This thesis focuses on an automated design of cache replacement policy optimized to a deployment on particular networks. A genetic algorithm is proposed to automate this process. The genetic algorithm generates and evaluates evolved replacement policies by a simulation on obtained traffic traces. The proposed algorithm is evaluated by designing replacement policies for two variations of the cache management problem. The first variation is an evolution of the replacement policy with an overall low number of state evictions from the flow cache. The second variation represents an evolution of the replacement policy with a low number of evictions belonging to large flows only. Optimized replacement policies for both variations are found while experimenting with various encoding of the replacement policy and genetic operators. The newly evolved replacement policies achieve better results than other tested policies. The evolved replacement policy lowers the overall amount of evictions by ten percent in comparison with the best compared policy. The evolved replacement policy focusing on large flows lowers the amount of their evictions two times. Moreover, no eviction occurs for most of the large flows (over 90%). The evolved replacement policy offers better resilience against flooding the flow cache with large amount of short flows which are typical side effects of scanning or distributed denial of service activities. An extension of the replacement policy is also proposed. The extension complements the replacement policy with an additional information extracted from packet headers. The results show further decrease in the number of evictions when the extension is used.
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Differentiation of offers and methods of working physiotherapy of persons with a mental or combined handicap in a practice of social service providers and another subjects.
POŠMUROVÁ, Nikola
In the Bachelor's thesis I have dealt with differentiation of tenders and rehabilitation methods. Specifically, individuals with mental or multiple disabilities and for providers of social services and other bodies. In the theoretical part I focused on defining the basic terms relating to that issue. In the introductory chapter I dealt with the definition of the concept of mental disability, causes of its creation and definition of degrees of mental retardation. The next chapter is devoted to the combined disability, specifically the yoke of the definition, causes of and classification. In the third chapter is devoted to the importance of the work, the status of the work in a person's life and the status of work for persons with disabilities, including individuals with mental or multiple disabilities in Bachelor thesis I. In the next chapter, I deal with comprehensive rehabilitation system, specifically the remedies rehabilitation, educational resources, social resources, rehabilitation, rehabilitation and special attention devoted work resources, rehabilitation, which will directly affect the Bachelor thesis. Furthermore, I determine a target group the work of rehabilitation and the preconditions for its implementation. In other chapters is devoted to the specification of tools and resources work rehabilitation, employment policy tools and I define jobs that are offered to persons with intellectual disabilities. In the practical part of the thesis, first determine the main aim and target work. The main goal was to determine what are the menus and methods of rehabilitation for people with mental or multiple disabilities with providers of social services. As the target I had set to determine what are the possibilities of transmission from individual to social services on the open employment market. Specifically, I've focused on the resources provided by the rehabilitation of daily, weekly care centers or day service center, in addition to the socio-therapeutic workshops, in a sheltered employment, and employment on the open employment market. To meet the objectives I used a qualitative approach, specifically the semi-structured interview with six providers of social services of the South Bohemian region The analysis of the information obtained, I discovered that if the device is operated daily, weekly social welfare institution or Centre, day services, the services provided are identical, not different from each other. In the case of socio-therapeutic workshops is the diversity of the wider, each device provides a variety of services, different options, some devices have socio-therapeutic workshops directly on the device, others have socio-therapeutic workshops and externally, outside of your device. Protected jobs are also in the majority of providers of social services offered both within and outside the device, always the odd jobs, such as in the kitchen, cleaning, in teahouses and the like. It always depends on the type and degree of disability, on the basis of a levy for the client to the appropriate activities. Location of the client on the open employment market is not very common in most devices, some devices that offer clients or do not provide. Partial objective was to detect transmission, I found that the only limiting factor is the client's disability that limits its options and device options, of course, that the services it offers and delivers. The aim of all devices is to achieve the greatest possible degree of autonomy of the client and allow it to advance from care centers or day service center in the socio-therapeutic workshops, found a protected job, and a job on the open employment market.
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Lifestyle of patients with peripheral arterial disease before and after surgery
REZKOVÁ, Helena
Theoretical background: Peripheral arterial disease is a serious disease of Loir limb arteries which originates from atherosclerosis. The theoretical part deals with the lifestyle. There are mentioned basic risk factors of chronic forms. Further described are the pathophysiology changes generated on the basis of atherosclerosis and related causes for the origin of the disease. Subsequently there are explained methods of classification, developed clinical symptoms, diagnosis and therapy. This section also looks at the role of a nurse in the care of patients with peripheral arterial disease. Objectives: The aim of this work was to evaluate how patients with peripheral arterial disease changed their lifestyle after invasive vascular surgery. There were provided the following research questions: How do patients with peripheral arterial disease approach to the prevention of risk factors? What is in patients with peripheral arterial disease the main impuls for the possible change of their lifestyle? What influences surgery patient's attitude to risk factors for peripheral arterial disease? How crucial is a lifestyle change in patients after surgery for peripheral arterial disease? Methods: The theoretical part is processed using expert sources. The empirical part of the theses was processed using qualitative research. The chosen technique for data collection was semi-structured interviews with patients, with prepared open questions. The research was done in several phases - the first interview was conducted at the patient admission department (before surgery), followed by the next phase after three months, and 6 months after surgery. The interviews were recorded on a prepared form, then transcribed into electronic form and analyzed by open coding method. Results: The research showed that surgery can sometimes be triggered by changes in the patient's lifestyle. The first interviews in the preoperative period focused on how respondents felt, what was their lifestyle before surgery for atherosclerotic changes of the lower extremities. One of the questions was focused on patient knowledge about risk factors for the development of PAD and possible prevention. The second phase of interviews took place 3 months after the surgery. It dealt with the question about the respndents´ lifestyle, the respondents in the postoperative period, whether there were any changes. Some positive changes occurred in eating and there were some changes in doing physical activity. The third stage was carried out six months after surgery, again in order to detect changes in lifestyle. Minor changes came in smoking habits, the issue of diet and physical aktivity. Questions were also focused on the psychological level. We found out who helped patients and what was most motivating in implementing changes. In the conclusion/summing up question the patients marked themselves ow they managed to make a change. Conclusion: The number of patients with peripheral arterial disease and other cardiovascular diseases is increasing. The basis is the start to modify risk factors, namely tobacco use,dietary habits, physical activity. The medical staff members participate on changes in patients´ lifestyle by appropriate education. The problem occurs when the patient despite the support of close people can not cope to carry a twist in their life. There should a medical staff member offer a professional help to deal with this important step. Practical use: The aim is to draw attention to the expansion of education about lifestyle changes for patients diagnosed with PAD also in the postoperative period. Patients who are released to home care should receive enough information that would convince them to change their attitude towards their health, and that surgery is only one of the ways to prevent further attacks and complications. Results can improve communication with patients and focus on increasing their awareness and possibly offer assistance.
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Environmental variables acquisition and evaluation
Ulrych, Vladislav ; Vasilenko, Alexandr (advisor)
The first part of thesis is devoted to the environment of the room in which is monitoring device intended - server room. There are description of calculating algorithms for proper sizing of cooling due to the heat. Further in this part is description of suitable senzors for monitoring device - physical principle, their proper use and meaning. Theoretical part also contains a list of several available ready commercial solutions of monitoring stations and their characteristics.
The second part is devoted to the assembly of monitoring device - physical build of hardware components, preparation s and connecting sensors, operating system installation, configuration and network preparation. The second part contains also instaling web server and configuration parts, that allows amek a web interface with presentation of measured physical quantities. Integration device with Simple Network Management Protocol (SNMP) for use with Zabbix monitoring system. Output from this work can be used for monitoring fundamental physical quantities in a small server room or in switch room.
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