|
|
Structure, molecular functions and oncogenic potential of suprabasin
Krátký, Marek ; Novák, Josef (advisor) ; Pimková, Kristýna (referee)
Suprabasin is a relatively recently discovered protein, originally studied for its role in the formation of the cornified envelope and keratinocyte differentiation. In recent years, research has focused on the oncogenic potential of suprabasin and its role in various types of diseases (e.g. myelodysplastic syndrome, atopic dermatitis or psoriasis). One of the isoforms of suprabasin has a predicted unique β-solenoid domain in its structure, which is characterized for the first time in this work. In addition to general information about the gene and isoforms of the suprabasin protein, the paper also summarizes important findings about the interaction of suprabasin with proteins of the EGFR/STAT3/Src, Wnt/β-catenin, NF-κB and AKT signaling pathways. The paper relates these findings to tumor properties to which suprabasin contributes, such as the ability of tumors to metastasize, immunosuppression and angiogenesis. The summary of the findings in this paper raises questions for future research, which undoubtedly holds important information about the structure, function and oncogenic potential of suprabasin. Keyword: Suprabasin, unconventional secretion, oncogenic potential, biomarker, cornified envelope
|
guest ::
