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Social relationships in feral populations of ungulates (with accent on environmental conditions)
Boušková, Adéla ; Komárková, Martina (advisor) ; Horáček, Ivan (referee)
The adaptation of feral ungulates to the environmental conditions is important topic nowadays, not only because they often feralise out of their original home-range, but also from the behavioural point of view. The aim of my work is to answer several hypotheses, covering the differences in social relationship of ungulates in the wild and domestic conditions and their connnections to the environment.The thesis describes the frequency and intensity of interindividual interactions (hierarchy, aggression and friendly behaviour) and compares this behaviour between feral and domestic animals. As a main result may be mentioned the fact that social structure of feral individuals is modified as a consequence of restrictions of social behaviour in the domestic conditions (creches in feral goats). The enhanced fertility, which resulted from the long lasting artifical selection process in the breeds, brought also increased fertility in the feral conditions. The sex ratio at birth was found not related to the feral state or captivity. I suggest that aggressive and friendly interactions are more common in the domestic, not in feral environment. Future research should be focused more throughly on the behavioural adaptations of feral animals.
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Recombinant production of bovine NK cell receptors
Böerová, Nikola ; Kavan, Daniel (advisor) ; Šulc, Miroslav (referee)
NK cells, which are part of the innate immune system, are increasingly gaining attention, especially due to their cytotoxic ability to kill tumor cells of certain lines and certain viral, bacterial or parasitic infestation of the body. They lay a role in organ transplantation, the fight against HIV and other autoimmune diseases. NK cells have been studied since the 70th of the 20th century, but the structures and physiological ligands of their receptors remain only partially understood, as does the exact role of these cells in the organism. They communicate with others through their receptors, that recognize the lack of expression of MHC class I glycoproteins on the surface of target cells, thereby preventing cell recognition by cytotoxic lymphocytes. This diploma thesis deals with the research of receptors from cattle (Bos taurus), which is not a traditional laboratory animal and my task was to contribute to research of the structure of this group of proteins. I dealt with the recombinant production of some of the most important representatives of NK receptors CD69, NKRP1 and NKG2D in bacterial cells. The findings published in this thesis are a continuation of my bachelor thesis and together can be beneficial for further research into structural proteins and thus may help as in veterinary medicine...
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