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Possibilities of platelet count evaluation by analyzer Sysmex XN in a group of patients with thrombocytopenia
Charvátová, Martina ; Fátorová, Ilona (advisor) ; Vrbacký, Filip (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Martina Charvátová Supervisor: Mgr. Ilona Fátorová Title of diploma thesis: Possibilities of platelet count evaluation by analyzer Sysmex XN in a group of patients with thrombocytopenia This diploma thesis deals with the problems of platelet count evaluation in thrombocytopenic patients. There are several principles of determination of platelet count, which are currently used. The aim of this thesis is to assess and analyze three of them (impedance, optical and fluorescence method) in 400 patients. The theoretical part includes topics like function and development of platelets, principles of their count determination and pathology associated with low platelet count. In the experimental part the obtained data is graphically and statistically evaluated to analyse the agreement between three measurements. Methods: Analysis of complete blood counts was performed by the analyzer Sysmex XN-10. Platelet counts were obtained from PLT-I, PLT-O and PLT-F methods. Some blood samples required a microscopic control of platelet morfology. Results: The obtained data was statistically evaluated with help of Wilcoxon test and Bland- Altman plots. Between all three methods very good...
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Platelets counting and substitution therapy
CHYTILOVÁ, Marcela
Thrombocytopenia can be simply defined as a blood platelet count of below 150 giga/l. With the routine measurement of platelet number by automated cell counters it is a relatively common finding. Before initiating further investigations it is important to confirm that a low platelet count is genuine by careful inspection. Either a small clot in the sample or platelet clumping can cause artefactual thrombocytopenia and lead to unnecessary intervention.
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