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Transcription motif finding algorithms
Peřinová, Barbora ; Škutková, Helena (referee) ; Maděránková, Denisa (advisor)
This bachelor thesis deals with finding transcription motifs in DNA sequences. The first part describes the DNA transcription process, the significance of transcription motifs and provides an overview of transcription motif databases. The second part contains the classification of transcription motif finding algorithms, and details seven existing algorithms. In the practical part, functions for the analysis according to the Oligo-Analysis algorithm were created. Created functions were validated on the artificially created sequences with introduced motifs. The analysis of two families of coregulated genes was realized and the results were compared with the values achieved by the authors of the Oligo-Analysis algorithm.
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Transcription motif finding in non-model organisms
Helešicová, Klára ; Jurečková, Kateřina (referee) ; Musilová, Jana (advisor)
This bachelor thesis deals with the search for DNA motifs in non-model organisms. The first part explains the process of transcription, the concept of mutual information and an algorithm using mutual information. The second part describes the distribution of motif searching methods and examples of algorithms. The third part contains an overview of transcription motif databases. The practical part contains a description of the creation of a dataset for a non-model organism, a description of the proposed algorithm and its testing on the dataset. Then, the results of the proposed algorithm were compared with the results of FIRE and MEME algorithms.
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Transcription motif finding in non-model organisms
Helešicová, Klára ; Jurečková, Kateřina (referee) ; Musilová, Jana (advisor)
This bachelor thesis deals with the search for DNA motifs in non-model organisms. The first part explains the process of transcription, the concept of mutual information and an algorithm using mutual information. The second part describes the distribution of motif searching methods and examples of algorithms. The third part contains an overview of transcription motif databases. The practical part contains a description of the creation of a dataset for a non-model organism, a description of the proposed algorithm and its testing on the dataset. Then, the results of the proposed algorithm were compared with the results of FIRE and MEME algorithms.
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Transcription motif finding algorithms
Peřinová, Barbora ; Škutková, Helena (referee) ; Maděránková, Denisa (advisor)
This bachelor thesis deals with finding transcription motifs in DNA sequences. The first part describes the DNA transcription process, the significance of transcription motifs and provides an overview of transcription motif databases. The second part contains the classification of transcription motif finding algorithms, and details seven existing algorithms. In the practical part, functions for the analysis according to the Oligo-Analysis algorithm were created. Created functions were validated on the artificially created sequences with introduced motifs. The analysis of two families of coregulated genes was realized and the results were compared with the values achieved by the authors of the Oligo-Analysis algorithm.
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