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The effect of environmental factors on mesenchymal stem cells
Hlávka, Jakub ; Krulová, Magdaléna (advisor) ; Vištejnová, Lucie (referee)
Mesenchymal stem cells (MSCs) have the potential to be a valuable therapeutic tool due to their capacity for differentiation and immunomodulation. However, in order to ensure their efficacy in clinical applications, it is necessary to gain a comprehensive understanding of the factors influecing their properties. This bachelor thesis investigates the influence of environmental factors, including physical activity, temperature and light exposure, on MSCs functionality. Additionally it desribes the underlying mechanisms involved in the action of these factors. Finally, it evaluates the theoretical implications of exploiting environmental cues to enhance MSCs properites. An understanding of how environmental conditions shape MSCs behavior is essential for optimising their therapeutic potential and advancing regenerative medicine strategies. Key words: mesenchymal stem cells, environmental factors, physical activity, temperature, light
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Temperature and relative humidity vertical profile in atmosheric boudary layer by drone
Fedorenko, Mykhailo ; Hovorka, Jan (advisor) ; Bendl, Jan (referee)
The lower 200 meters of the atmospheric boundary layer (ABL) is characterized by a high amount of atmospheric pollutants, whose distribution and transport can be predicted based on vertical profiles of specific physical parameters. Therefore, acquiring detailed vertical profiles in this range is essential. Traditional methods of measuring vertical profiles are not fully applicable in the context of the SL range. Radiosondes are not designed for frequent measurement of vertical profiles within 200 meters, and remote sensing methods often lack the spatiotemporal resolution needed for detailed measurements of such profiles, can monitor only certain parameters, have specific operational characteristics, and are associated with high costs. In contrast to these methods, the use of a drone as a mobile platform offers advantages in the form of high spatiotemporal resolution and the ability to profile at short intervals, which enables the capture of detailed dynamics of vertical profiles within 200 meters. In this work, using the DJI Air 2s drone equipped with an iMet-XQ2 sensor, measurements of temperature (T) and relative humidity (RH) vertical profiles were conducted. The drone's vertical ascent speed was approximately 1 m/s, so measuring a profile up to 120 meters typically took about 120 seconds, with...
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Effect of temperature on sand fly biology and Leishmania transmission
Charvátová, Lada ; Sádlová, Jovana (advisor) ; Dvořák, Vít (referee)
and keywords The current rise in air temperature causes a range of global changes, affecting many species of organisms and their interactions. Phlebotomine sand flies are small members of Dipteran insects of the family Psychodidae, subfamily Phlebotominae, transmitting Leishmania, parasitic flagellates (Kinetoplastida: Trypanosomatidae) that cause the important human disease leishmaniasis. Based on the literature review, the external temperature significantly affects the biology of sand flies. High temperature accelerates their metabolism and shortens the growth rate of immature stages, also influencing body size and body weight (faster development in higher temperatures makes them smaller). The time needed for blood digestion is also reduced, and female defecation and oviposition are accelerated. On the other hand, cold temperatures prolong growth, and cause lower emergence of adult sand flies, slower digestion of blood, or number of laid eggs. Very high or very low temperatures can cause diapause in the larval stage or eggs. In general, the optimal temperature to cover all of their physiological needs is 24-28 řC. Temperature impacts the development of Leishmania in sand flies as well, it is likely that Leishmania has a lower optimal temperature as opposed to sand flies, and therefore some...
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Effect of global climate change on areal and phenology shifts of dragoflies species
Perthen, Ervín ; Černý, Martin (advisor) ; Bílková, Eva (referee)
Climate change in recent decades affects the distribution and phenology of dragonflies. The main factor causing these changes is the increase in the average global temperature, but other factors, such as loss of habitats or changes in precipitation regime, also play a role. As a result of climate change, phenological processes are accelerating. We can therefore observe a faster egg development rates, an earlier emergence of adults, a longer flight period and also a shift in voltinism towards a greater number of generations per year. Good dispersal abilities allow dragonflies to respond to changing environmental conditions also by shifting their distribution. The ranges of most species are currently expanding towards the poles. Generalists and species capable of using temporary waters expand their ranges the most, while specialized species with a narrow niche are the most threatened by climate change. Shifts are also visible in the altitudinal distribution, increasing temperatures allow warm- adapted species to expand their ranges to higher altitudes. Keywords: climate change, dragonflies, distribution, phenology, temperature, altitudinal shift
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Arctic amplification: causes, manifestations, impacts
Houser, Mikoláš ; Huth, Radan (advisor) ; Krauskopf, Tomáš (referee)
The Arctic amplification is a byproduct of the climate change, manifested by faster warming in the Arctic region compared to other parts of the planet. This paper summarises the basic understanding of the mechanisms underlying this phenomenon (mainly snow-ice albedo and temperature feedback) and the potential impacts of Arctic amplification for atmospheric circulation at mid-latitudes. The research is completed by a correlation analysis describing the relationship between Arctic amplification and the North Atlantic Oscillation. Based on the literature it is suggested that Arctic amplification may influence various factors of the mid-latitude atmospheric circulation (e.g., phases of the North Atlantic Oscillation, jet stream, circumpolar vortex), but natural variability of the climate makes it difficult to unravel this relationship. Recent climate model outputs seems more likely to show a smaller influence of Arctic amplification compared to the internal variability of the climate system. This is demonstrated by the results of the correlation analysis, which show very little statistical connection of the observed variables and large statistical uncertainty in the results.
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Simplified design of heat exchangers using MS Excel
Konečný, Ondřej ; Jegla, Zdeněk (referee) ; Kilkovský, Bohuslav (advisor)
This bachelor thesis deals in the first part with the research, where the types of heat exchangers are briefly described. The next part contains the basic equations for the calculation of heat exchangers as well as different approaches to the calculation of these devices. The practical part of this thesis focused on the development of the calculation tool, the corresponding manual and the functionality checking with examples.
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Design and developement of autonomous system for monitoring critical paramaters in food industry
Chovan, Hynek ; Formánek, Martin (referee) ; Krejčí, Petr (advisor)
his work focuses on automating the monitoring of temperature and other operational parameters in gastronomic establishments. The designed device allows real-time monitoring of temperature, humidity, and other parameters with remote access capability. It utilizes the ESP32 microcontroller, SHT40 and HX711 sensors, and TP4056 charging circuit with DW01A protection circuit. Data is transmitted to a Gateway device, which displays it through a web interface. Testing demonstrated sufficient communication range and long battery life. The device meets requirements for compactness, reliability, and efficiency. This project represents progress in IoT applications for ensuring food safety and efficiency in handling food in gastronomic establishments.
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Possibilities of limiting unwanted phenomena during chip finishing machining
Handl, Jiří ; Osička, Karel (referee) ; Kalivoda, Milan (advisor)
The diploma thesis focuses on the possibilities of limiting undesirable phenomena during finishing chip machining. In the theoretical part, selected negative phenomena arising during turning are described and the possibilities of their limitation are investigated. In the experimental part, an analysis of the influence of cutting conditions from the recommended range of the cutting tool using the turning method is carried out. Specifically, the dependence of the cutting speed and feed rate on the size of the cutting force, temperature and resulting surface quality for two different materials is monitored. The obtained results serve to understand the issue and optimize the production process.
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Optimising the working environment through Internet of Things technologies
Šebo, Martin ; Matej,, Havlas (referee) ; Sedlák, Petr (advisor)
This master’s thesis is focused on the analysis of the working environment of Stellnaris s.r.o. through the Internet of Things devices in terms of temperature, humidity, air quality and noise. The aim of the thesis is to analyze and propose the optimization of the monitored premises so that the network elements (especially the active ones) run as efficiently as possible, their long lifetime is achieved and also so that the comfort of the persons present in the premises is achieved in case of work performance. The subject of this work is not the monitoring of the entire company premises, but only selected areas, which are specified in more detail in the chapter Analysis of the current state.
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Short time overload of cables in UPS applications
Toman, Dominik ; Pravda, Luděk (referee) ; Šimek, David (advisor)
This bachelor’s thesis is about dimensioning power cables in electrical instalation which is described in the third chapter. If is used cable with small cross-section, relatively high direct current which is flowing through these cables could cause too high warming. Function of this electrical instalation and comparison of batteries which should be possibly used, are described in the first chapter. Second chapter shows risk of using cable with small cross-section, which could be overheated due to current overloading. Cables are designing in accordance with IEC 60364-5-52, IEC 60364-5-54 and duty cycle. Cross section values calculated according to all methods are very different. Cross section calculated in accordance to IEC 60364-5-54 and duty cycle are smaller then cross-section values calculated in accordance to IEC 60364-5-52. Cable with smaller cross section is cheaper, but it is possible that smaller cross section could cause bigger warming. This thesis also contains thermal model and warming measurement, both methods are for verification that cable with smaller cross-section could be used. Third chapter also contains calculations of voltage drops on all calculated cross-sections. Values from thermal model and warming measurement are different but they are both confirming that the cable with smaller cross section could be used.
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