National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Nephrotoxicity testing in vitro
Handl, Jiří ; Roušar, Tomáš (advisor) ; Patočka, Jiří (referee) ; Andrýs, Rudolf (referee)
2020 UNIVERSITY OF PARDUBICE FACULTY OF CHEMICAL TECHNOLOGY Doctoral Thesis: NEPHROTOXICITY TESTING IN VITRO Author: Mgr. Jiří Handl, Ph.D. Supervisor: doc. RNDr. Tomáš Roušar, Ph.D. Abstract The doctoral thesis deals with in vitro testing of nephrotoxic effects of substances in immortalized human proximal tubular cells HK-2. The basic aim of the thesis was to introduce and optimize the cultivation of HK-2 cells under different culture conditions, to characterize the cultivation and growth stability of HK-2 cells and last but not least to characterize the nephrotoxic effect of cadmium in HK-2 cell line using bioanalytical and biochemical methods. The introduction summarizes the basic rules and conditions for long-term cultivation of cell lines. Furthermore, HK-2 cells and their importance in nephrotoxicity testing are characterized in detail. The thesis also mentions methods for monitoring toxic effects of substances with focus on measuring cell viability and oxidative stress. The outcomes of the thesis are characterizing nephrotoxic effects of CdCl2 in HK-2 cells. The results part describes obtained findings and the discussions follows. Keywords Nephrotoxicity; In vitro cultivation; HK-2 cell line; Cell viability; Cadmium.
Microstructure of Mg alloys prepared by SLM process
Handl, Jiří ; Vašáková, Kristýna (referee) ; Nopová, Klára (advisor)
The main aim of this bachelor thesis was to research for theoretical part dealing with additive manufacturing and magnesium alloys focused on alloy AZ91D. The experimental work analyzed samples processed by Selective laser melting (SLM) technology with different process parameters. The porosity was measured on the individual samples and the microstructure of alloy AZ91D processed by SLM method was described. The results were linked to the process parameters used and, also to the available literature.
Supply Management During Implementation of New Information System
Tyralíková, Alžběta ; Handl, Jiří (referee) ; Juřica, Pavel (advisor)
This diploma thesis deals with inventory management during company transition Sanmina-SCI Česká republika s. r. o. to new information systems. First are explained the basic and specialized concepts of logistics, information systems and introduces related issues to the reader. Other parts of the thesis deal with analysis and suggestions for possible solutions to streamline planning of the purchase of material elements.

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2 HÁNDL, Jan
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