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Evolution of PTC bitter taste receptors in West Africa
Holoubková, Tereza ; Černý, Viktor (advisor) ; Macholán, Miloš (referee)
The aim of this thesis is to determine whether the TASR38 gene is under selection pressure in West Africa and if its diversity varies within populations practicing different modes of subsistence. It further focuses on polymorphisms occurring in the gene and their association with sensitivity to the bitter tasting compound PTC. The thesis analyses 147 samples of saliva from three Mauritanian populations in order to sequence the DNA of the TAS2R38 gene exon. Ten polymorphic sites conditioning 16 haplotypes were observed in TAS2R38 gene. Mutations in amino acid positions 49, 262 and 296 occurred in all three populations; all eight possible haplotypes were observed. 94 % of them constitutes major PAV and AVI haplotypes and AAI haplotype, all of which were detected in each of the three populations. Additionally, 14 genotypes were identified in our sample; the most common being those created by a combination of the three haplotypes. Kruskal-Wallis test showed that TAS2R38 genotypes are strong predictors of PTC response in the examined African populations. PAV haplotype is associated with sensitivity to PTC (taster haplotype); conversely, AVI is a nontaster haplotype. At the same time, it was confirmed that PAV is an ancestral haplotype evolutionary closest to the chimpanzee TAS2R38 gene and it probably...
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The Paper on Understanding the Subsistence Manner on the Transition of Neolithic and Eneolithic Age (a Comparative Study between the Western Culture Complex and Regions of Bohemia and Moravia)
Mattová, Sabina ; Popelka, Miroslav (advisor) ; Neustupný, Evžen (referee) ; John, Jan (referee)
The study presented deals with the phenomenon of increased hunting activity on the transition of the Neolithic and Eneolithic Age, the reasons of which have been so far investigated only in regard to environmental conditions of locations. The phenomenon is observed on locations of a wide area of Middle Europe. Nevertheless, there exist locations with prevailing agricultural economy. On the basis of a detailed comparative analysis of the material culture of the Western culture circle and Bohemia and Moravia, the study aims to trace the reflection of the phenomenon in archaeological materials - differences between locations with predominant domestic sources, and locations with predominant wild sources. Alongside, the study deals with a possible environmental impact on increasing hunting tendencies. In order to created a database, a detailed catalogue of locations has been compiled. The catalogue holds the most essential information on material culture with regard to expected agricultural manners. The catalogue also serves as a clue for setting particular indicators of the database, the purpose of which is to organise the data in a comparable form. Subsequently, a descriptive database has been compiled. The database traces the reflection of agricultural base of the individual locations. By means of a...
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The Paper on Understanding the Subsistence Manner on the Transition of Neolithic and Eneolithic Age (a Comparative Study between the Western Culture Complex and Regions of Bohemia and Moravia)
Mattová, Sabina ; Popelka, Miroslav (advisor) ; Neustupný, Evžen (referee) ; John, Jan (referee)
The study presented deals with the phenomenon of increased hunting activity on the transition of the Neolithic and Eneolithic Age, the reasons of which have been so far investigated only in regard to environmental conditions of locations. The phenomenon is observed on locations of a wide area of Middle Europe. Nevertheless, there exist locations with prevailing agricultural economy. On the basis of a detailed comparative analysis of the material culture of the Western culture circle and Bohemia and Moravia, the study aims to trace the reflection of the phenomenon in archaeological materials - differences between locations with predominant domestic sources, and locations with predominant wild sources. Alongside, the study deals with a possible environmental impact on increasing hunting tendencies. In order to created a database, a detailed catalogue of locations has been compiled. The catalogue holds the most essential information on material culture with regard to expected agricultural manners. The catalogue also serves as a clue for setting particular indicators of the database, the purpose of which is to organise the data in a comparable form. Subsequently, a descriptive database has been compiled. The database traces the reflection of agricultural base of the individual locations. By means of a...
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