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The effect of psychedelics on sleep
Šachová, Pavla ; Kopřivová, Jana (advisor) ; Spišská, Veronika (referee)
Recently, psychedelic drugs gain attention thanks to their potential to cure depressive disorders, anxious states or addiction. They are not causing addiction, they are not toxic and they trigger neuroplastic changes in tens of minutes or hours, which are essential for therapeutic purposes and positively correlates with an onset of antidepressant effect. Neuroplastic changes are simultaneously the connecting link between psychedelic state and sleep. In sleep the higher rate of neuroplasticity is markable during slow-wave sleep (SWS), which duration is getting shorter in patients with mental illness. The marker o neuroplasticity is slow-wave activity (SWA), which is getting higher not only in SWS, but also after intoxication with psychedelics or after long-time using of antidepressants. So the effect of psychedelics on sleep can be described as positive and inciting its therapeutical potential. The thesis is focused on ketamine which is the most recent one as for the topic of neuroplasticity and sleep.
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The effect of psychedelics on sleep
Šachová, Pavla ; Kopřivová, Jana (advisor) ; Spišská, Veronika (referee)
Recently, psychedelic drugs gain attention thanks to their potential to cure depressive disorders, anxious states or addiction. They are not causing addiction, they are not toxic and they trigger neuroplastic changes in tens of minutes or hours, which are essential for therapeutic purposes and positively correlates with an onset of antidepressant effect. Neuroplastic changes are simultaneously the connecting link between psychedelic state and sleep. In sleep the higher rate of neuroplasticity is markable during slow-wave sleep (SWS), which duration is getting shorter in patients with mental illness. The marker o neuroplasticity is slow-wave activity (SWA), which is getting higher not only in SWS, but also after intoxication with psychedelics or after long-time using of antidepressants. So the effect of psychedelics on sleep can be described as positive and inciting its therapeutical potential. The thesis is focused on ketamine which is the most recent one as for the topic of neuroplasticity and sleep.
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Psychedelics in psychology
DRAHÁ, Eliška
The bachelor thesis focuses on the current renaissance of the use of psychedelics in psychological research and practice. The thesis offers both a view into the history of the use of the effects associated with the use of psychedelics, and above all focuses on the findings of the latest research. It summarizes the research findings dealing with their therapeutic effects in the treatment of mental illnesses. Two areas of psychedelic use in treatment are described in more detail. There is an overview of researches from 1965 to 2016 dealing with dying patients in the terminal stage of the disease. The second area includes psychological factors affecting addiction treatment and summarizes the results of several studies dealing with different types of addiction.
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Thinking the psychedelic
Michalik, Tadeáš ; Marek, Jakub (advisor) ; Novák, Aleš (referee)
2 Abstract In this text, we are asking if it is possible to think the 'psychedelic' without labelling it as 'different', 'imaginary', 'fantastic' or 'unreal', and without thinking it as a particular experiential region belonging specifically to human experience. By first thinking 'experience', we are then attempting to relate the psychedelic experience to human experience considered in the simple joining of its basic dimensions, and to think both of these experiential modalities through the same motives. If we think 'experience' as opening itself through its boundaries, which limit and thus open the dimensions through which the fundamental relation of presencing and apprehension plays, then we can think the psychedelic using the concept of 'layer' derived from the concept of 'boundary'. We first think the phenomena of transparency of time, of transparent attunement and of transparent clarity, which belong to human experience in its simplicity. We then think the phenomenon of disjoining of the basic dimensions of human experience, which takes us from human experience in its simplicity, through strangeness, towards the psychedelic. Lastly, we think the phenomenon of permeating, taking us to the simply joined or disjoined dimensions of human and non-human experience being played out in their layeredness...
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Psychedelics and mechanisms of their effect on the CNS
Vejmola, Čestmír ; Novotný, Jiří (advisor) ; Páleníček, Tomáš (referee)
Psychedelics represent the group of psychotropics, which induce characteristic cognitive, perceptual and emotional symptoms. They are represented by simple indolamines (psilocybin or DMT), ergoline derivatives (LSD), and substituted phenylethylamines (mescaline). This work with a systematic approach to the problem attempts to characterize the underlying basis of physiological effects of psychedelics in brain. After the general characterization of hallucinogens, among which psychedelics belong to, the first part is focused on the common psychological and physiological actions and risks associated with them. Follows the pharmacological characterization of selected representatives especially with regard to their origin, ways of administration, effects, distribution and metabolization in body. A large part is devoted to the description of G-protein-coupled receptors functioning. The principal part is the last one, which describes mechanisms of action of psychedelics at the cellular level such as well as in different brain regions.
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