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Characteristics of gait impairment and possible therapeutic interventions in people with multiple sclerosis.
Novotná, Klára ; Kubala Havrdová, Eva (advisor) ; Čakrt, Ondřej (referee) ; Taláb, Radomír (referee)
Walking disorders are one of the most visible symptoms of multiple sclerosis (MS). Multiple sclerosis (MS) is a chronic autoimmune neurodegenerative disease of the central nervous system that is the most common cause of disability of young adults. Walking disorders are one of the most common motor problems that accompany this disease, which patients themselves perceive as the most limiting. Walking disorders can be caused by many symptoms of MS such as: muscle weakness, spasticity, sensory disturbances, visual disturbances, sphincter problems, cognitive dysfunction, fatigue and thermosensitivity. Measuring of various gait parameters (most often speed and endurance) also helps to monitor the effects of treatment and to evaluate the progression of the disease. Even in patients with minimal neurological symptoms it is possible to detect deterioration of gait parameters. Realized studies have shown that subjectively perceived improvement in gait after treatment with natalizumab can be objectified with the aid of assessment of walking parameteres. Similarly, a functional gait test can be used to assess the therapeutic response (and thus evaluate the cost effectiveness of treatment) to symptomatic treatment with fampridine. As a physiotherapist, I was also interested in the possibility of influencing...
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