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Prognostic impact of nutritional status of patients with head and neck cancer on the efficacy of concomitant radio(chemo)therapy: A prospective clinical trial.
Králová, Anna ; Dršata, Jaroslav (advisor) ; Vítek, Pavel (referee)
The study is designed as a prospective clinical trial. Patients with histologically proven head and neck cancer treated by curative radiotherapy were included. The aim of this study was to investigate the relationship between pretreatment or posttreatment nutritional status and overall surival or locoregional / distant control. Pretreatment and posttreatment nutritional status was evaluated by body weight, body mass index, total serum protein, albumin, prealbumin, transferin and cholinesterase. Univariete and multivariete regression analyses were applied for prognostic factors associated with survival or tumor control. In this study we demonstrated, that poorer nutritional status prior curative radiotherapy, has a negative impact on subsequent control of cancer. The most sensitive parameter was serum cholinesterase. Serum cholinesterase 108 kat/l was the independent negative prognostic factor for both locoregional and distant tumor control. Results of this study indicate the need for intensive nutritional support before starting of curative treatment.
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Eating habits and behaviors of Czech adolescents in relation to their body weight
Paterová, Zuzana ; Hlavatá, Karolína (advisor) ; Vašíčková, Jitka (referee)
The prevalence of obesity in children and adolescents has reached pandemic proportions nowadays. Obese individuals are at risk of cardiovascular diseases, type 2 diabetes, dyslipidemia, musculoskeletal diseases, etc. Children increasingly live a sedentary lifestyle and consume high-energy food with poor combination of nutrients. In the Czech Republic, however, there exist no comprehensive structure for the fight against child obesity and a lack of meaningful data on the prevalence of obesity in adolescent population. This work is drawn up under the project COPAT. The bachelor's thesis deals with the issue of basic nutrients and their relationship to weight, dietary recommendations for adolescents, the assessment of nutritional status, etiology of obesity and obesity-related complications. The main emphasis is placed on the practical part, which focuses on results of the research, which provides information about dietary habits and behaviour of 100 adolescents in relation to their body weight. Key words: obesity, nutrition, nutritional status, adolescents, health risks
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