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Clinical Applicability of Cognitive Testing in Huntington Disease
Mühlbäck, Alžbeta ; Klempíř, Jiří (advisor) ; Rusina, Robert (referee) ; Horáková, Hana (referee)
Introduction: Huntington disease (HD) is an autosomal dominant neurodegenerative disorder manifested by motor, behavioural and cognitive deficits with fatal consequences. Aims: This study aims to validate the psychometric properties of a standard cognitive battery used in HD and establish language-specific normative values. Methods: In the first study, cognitive performance was compared in 106 patients at different stages of HD and 100 healthy controls matched for age, sex, and education. The neuropsychological battery included the Symbol Digit Modalities Test, Stroop Word Reading Test, Stroop Colour Naming Test, Stroop Interference Test, Trail Making Test-A and B, Category and Letter Verbal Fluency. In addition, patients were comprehensively assessed for motor and functional status. In the second study, the cognitive performance of 3,267 healthy subjects was assessed. The work focused on the stratification of cognitive performance concerning age, gender, language and level of education. Another aim was to establish the language-specific normative values and implement a web-based normative calculator to assess the degree of cognitive deficit in different languages (English, German, Spanish, Italian, Polish, French, Dutch, Danish). Results: In the first study, analysis of variance showed that healthy...
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Depression and the Beck Depression Inventory: Normative Study of the Czech Version and Comparison with Foreign Data
Čihařová, Markéta ; Šivicová, Gabriela (advisor) ; Loneková, Katarína (referee)
The thesis is dealing with the topic of depression and measurement instruments, which may contribute to its diagnostics and assessment. Special attention is dedicated to the Beck Depression Inventory, second edition, and the aim of this thesis is to provide normative data acquired from a large sample of healthy adult participants coming from the Czech Republic (N = 450; aged 18 to 96 years). The Beck Depression Inventory, second edition (BDI-II; Beck, Steer, & Brown, 1996) belongs among the most famous and most often used measures of depression severity. A significant relationship was found between the BDI-II total score and gender and education level, but not age. Women tended to score significantly higher than men on average, and a negative correlation between the BDI-II total score and education was found. Therefore, the normative data were analysed and stratified according to these two demographic variables. Tables, presenting means, standard deviations, percentiles and standard scores are provided for the total unstratified sample as well as for demographically defined subgroups. In addition, internal consistency of the Czech version was high (alpha above .80). The item-total correlations, and factorial structure of the instrument were investigated and the results were compared with results...
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Depression and the Beck Depression Inventory: Normative Study of the Czech Version and Comparison with Foreign Data
Čihařová, Markéta ; Šivicová, Gabriela (advisor) ; Loneková, Katarína (referee)
The thesis is dealing with the topic of depression and measurement instruments, which may contribute to its diagnostics and assessment. Special attention is dedicated to the Beck Depression Inventory, second edition, and the aim of this thesis is to provide normative data acquired from a large sample of healthy adult participants coming from the Czech Republic (N = 450; aged 18 to 96 years). The Beck Depression Inventory, second edition (BDI-II; Beck, Steer, & Brown, 1996) belongs among the most famous and most often used measures of depression severity. A significant relationship was found between the BDI-II total score and gender and education level, but not age. Women tended to score significantly higher than men on average, and a negative correlation between the BDI-II total score and education was found. Therefore, the normative data were analysed and stratified according to these two demographic variables. Tables, presenting means, standard deviations, percentiles and standard scores are provided for the total unstratified sample as well as for demographically defined subgroups. In addition, internal consistency of the Czech version was high (alpha above .80). The item-total correlations, and factorial structure of the instrument were investigated and the results were compared with results...
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