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Consequences of experimentaly induced perinatal cerebral ischemic lesion
Bahníková, Eva ; Otáhal, Jakub (advisor) ; Konopková, Renata (referee)
1 Abstract Title: Consequences of experimentally induced perinatal cerebral ischemic lesion. Aim: This thesis aims to present the issues and analyze current knowledge in the field of perinatal brain damage, particularly perinatal cerebral ischemic lesions as the most common brain infarction in children. Basic characteristics of the disease, syndromology, pathophysiological mechanisms and risk factors are emphasized. Following the theoretical background the thesis analyzes current trends as well as the limitations of the diagnostics and therapy. The aim is to highlight the need for early diagnosis and emphasize the potential of preventive treatment strategies. The practical part follows the theoretical background and expands the topic on the analysis of motor and behavioral consequences of experimentally induced perinatal ischemic stroke. Method: Cerebral focal ischemia was induced experimentally by photothrombotic method to seven days old rats. Rose Bengal intravenously followed by continual illumination of the senzorimotor cortex using a green laser beam for 10 minutes was induced platelet aggregation and subsequent thrombosis. Eight animals at age of two months were evaluated for 7 days via observational cages PhenoTyper. Results: The theoretical part collected and processed theoretical data on the...
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Physical activity of children with motor difficulties
Kokštejn, Jakub ; Psotta, Rudolf (advisor) ; Zelinková, Olga (referee) ; Sigmund, Erik (referee)
Bibliographic identification Name and surname of the author: Mgr. Jakub Kokštejn Name of the dissertation: Physical activity of children with motor difficulties Workplace: Department of Sports Games Supervisor of the work: Doc. PaedDr. Rudolf Psotta, Ph.D. Year of presentation: 2011 Abstract Objective: Current knowledge of developmental disorders in motor skills of school children suggest potential negative impacts on the development of the personality of the child in the mental, social psychological and behavioural areas and also in the area of competence at school. Very little is known about how an insufficient level of motor skills of a child can limit his/her physical activity. This work was performed to discover whether developmentally determined motor deficit in children of older school age is a risk factor for lower physical activity (PA) and whether the attention of the child has a mediation function in the relationship between the level of motor skills and his/her physical activity. Methods: The research was based on analytical-descriptive examination of the motor skills of children, their physical activity in weekly regimes and the attention level, with subsequent comparison of children with a motor deficit (MD) and children without MD, through correlation analysis and analysis of the mediative...
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Grasp evaluation in patients after stroke
Pomyjová, Šárka ; Krivošíková, Mária (advisor) ; Rybářová, Kateřina (referee)
Title of diploma thesis: Grasps evaluation in patients after a stroke Objective: The main goal of the pilot study was to determine minimal clinically important difference in selected tests focusing on improvement in the grasps of patients in the chronic phase post stroke. The main hypothesis was set to prove that the differences between the initial and final assessments based on the Modified Frenchay Scale characterizes patients' improvement more accurately than the Score for visual evaluation of functional task of the hand. Methods: The research group consisted of 40 participants (26 men and 14 women) all in the post stroke chronic phase who were selected based on the criteria for inclusion in the research. Data was collected at the Department of Rehabilitation Medicine and the First Faculty of Medicine. Using video documentation of the Modified Frenchay Scale used during both the initial and final assessment, the test itself was then analysed. A 3rd subtest was also used to evaluate the Score for visual evaluation of functional task of the hand. Using the Spearman correlation coefficient, the statistically significant level was established (p <0,05) followed by calculating the critical value of the Spearman correlation coefficient (rsp (0,05,40) = 0,264), and thus verifying the hypothesis. Results: The...
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Functional consequences of perinatal hypoxia-ischemia in rat
Nováková, Eva ; Otáhal, Jakub (advisor) ; Riljak, Vladimír (referee)
Title: Functional consequences of perinatal hypoxia-ischemia in rat Objectives: The aim of this diploma thesis is to design a set of behavioral tests which provide an effective assessment of motor and cognitive-behavioural deficits in adults rats after experimental hypoxic-ischemic insult during the perinatal period (P7). Supposed benefit is to establish a model of motor and cognitive-behavioural abilities of individuals after this procedure. Methods: The present thesis has a theoretical-empirical character. The practical part describes how the experiment was performed. 32 long Evans Rats were randomly devided into two groups: experimental group (HIE) and control group (Ctrl). The method to produce hypoxic-ischemic brain damage in the 7 day-old rats consisted of right common carotid ligation followed by systemic hypoxia by the inhalation of 8% oxygen and 92% nitrogen. The adult animals (55-75 days old) were tested by the following list of behavioral tests: Bar holding test, Rotarod test, Ladder rung walking test, Reaching test, Open field test and Morris water maze test. Sigma Plot and Microsoft Excel 2010 were the programs used for statistical analysis. Results: Results of Open field test, Ladder rung walking test and Morris water maze test confirmed that hypoxic-ischemic insult affects the...
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Consequences of experimentaly induced perinatal cerebral ischemic lesion
Bahníková, Eva ; Otáhal, Jakub (advisor) ; Konopková, Renata (referee)
1 Abstract Title: Consequences of experimentally induced perinatal cerebral ischemic lesion. Aim: This thesis aims to present the issues and analyze current knowledge in the field of perinatal brain damage, particularly perinatal cerebral ischemic lesions as the most common brain infarction in children. Basic characteristics of the disease, syndromology, pathophysiological mechanisms and risk factors are emphasized. Following the theoretical background the thesis analyzes current trends as well as the limitations of the diagnostics and therapy. The aim is to highlight the need for early diagnosis and emphasize the potential of preventive treatment strategies. The practical part follows the theoretical background and expands the topic on the analysis of motor and behavioral consequences of experimentally induced perinatal ischemic stroke. Method: Cerebral focal ischemia was induced experimentally by photothrombotic method to seven days old rats. Rose Bengal intravenously followed by continual illumination of the senzorimotor cortex using a green laser beam for 10 minutes was induced platelet aggregation and subsequent thrombosis. Eight animals at age of two months were evaluated for 7 days via observational cages PhenoTyper. Results: The theoretical part collected and processed theoretical data on the...
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The effect of dynamic neuromusculur stabilization on motor deficit in patients after stroke
Zelenková, Jana ; Kobesová, Alena (advisor) ; Demeková, Júlia (referee)
The aim of the study was to evaluate the effect of specific rehabilitation concept on the motor deficit in patients after stroke. This concept is used at the Department of inpatient rehabilitation FN Motol, the main component is exercise on the principles of dynamic neuromuscular stabilization (DNS) and is based on the principles of developmental kinesiology. The study included 12 patients after stroke. Probands participated in the 3 week therapy, exercise was carried out twice a day. Significant (p <0.05) improvement in motor function of the arm, hand, leg and foot was demonstrated by using Student`s paired t-test. There was a statistically significant improvement in postural control and reducing shoulder pain (all assessed using a specific scale: Chedoke McMaster Stroke Assessment). Changes in the degree of spasticity were evaluated by Modified Ashworth scale. A statistically significant improvement in the degree of spasticity was observed in these muscle groups: the elbow flexors , adductors of lower limb, knee extensors and hamstrings. It has been shown that the concept of dynamic neuromuscular stabilization can be advantageously used in selected patients after stroke. It is appropriate to supplement the DNS therapy with training of ADL.
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Physical activity of children with motor difficulties
Kokštejn, Jakub ; Psotta, Rudolf (advisor) ; Zelinková, Olga (referee) ; Sigmund, Erik (referee)
Bibliographic identification Name and surname of the author: Mgr. Jakub Kokštejn Name of the dissertation: Physical activity of children with motor difficulties Workplace: Department of Sports Games Supervisor of the work: Doc. PaedDr. Rudolf Psotta, Ph.D. Year of presentation: 2011 Abstract Objective: Current knowledge of developmental disorders in motor skills of school children suggest potential negative impacts on the development of the personality of the child in the mental, social psychological and behavioural areas and also in the area of competence at school. Very little is known about how an insufficient level of motor skills of a child can limit his/her physical activity. This work was performed to discover whether developmentally determined motor deficit in children of older school age is a risk factor for lower physical activity (PA) and whether the attention of the child has a mediation function in the relationship between the level of motor skills and his/her physical activity. Methods: The research was based on analytical-descriptive examination of the motor skills of children, their physical activity in weekly regimes and the attention level, with subsequent comparison of children with a motor deficit (MD) and children without MD, through correlation analysis and analysis of the mediative...
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