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Mammary diagnostics - attitude and awareness of women
HRBKOVÁ, Jana
Over 7000 cases of breast cancer are diagnosed each year, which makes it the most common malignant disease in women in the Czech republic. Despite its constantly increasing incidence, mortality rates are stagnating and recently these rates even have tended to decrease slightly. The most common methods used for breast examination are mammography and ultrasonography. Nationwide breast cancer screening programme was launched in the Czech republic in 2002. This screening helps to detect cancer at an early stage. Mammography screening is covered by public health insurance for all women over the age of 45 once per two years. Breast self-exam is also a big part of secondary prevention. The purpose of this bachelor thesis was to analyze breast cancer prevention and mammary diagnostic awareness of women over the age of 18. In order to collect necessary data for my thesis a questionnaire survey was conducted. The electronic survey, which I created on website www.vyplnto.cz, was filled in by 533 female respondents. All the results of the survey were displayed in pie charts. Questions no. 10-23, which were focused on awareness, were also displayed in bar charts. These bar charts show the percentage of correct answers by age category. Thanks to the data from the survey I was able to answer research questions. In the first research question, I asked which age group has the least awareness of breast cancer prevention and mammary diagnostic; in the second research question, I wanted to know if more than 50 % of interviewed women perform breast self-examination. I evaluated that the oldest age group, i.e. respondents over the age of 65, has the least awareness of breast cancer prevention and mammary diagnostic. The survey also revealed that more than 50 % of interviewed women perform breast self-examination.
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Influence of tumor microenvironment, cellular and humoral immunity on cancer pathogenesis.
Špaček, Jan ; Závadová, Eva (advisor) ; Petráková, Katarína (referee) ; Kopečková, Kateřina (referee)
Cancer is the second leading cause of death in the Czech Republic. Breast cancer and colorectal cancer have relatively high mortality rate. One of the areas of current clinical research in oncology is the study of prognostic biomarkers, which aims to optimize the decision-making process for a patient. Immune response and processes in the tumor microenvironment have been shown to influence to a large extent the biological nature of the tumor in terms of its aggressiveness and ability to metastasize in the host's body. There are certain tumors that could induce a strong immune response, while others do not. The ability to induce an anti-tumor cell response and to attract specific lymphocyte subpopulations directly into tumor tissue has been shown to be very closely related to the prognosis of cancer patients. There is evidence and correlation of the presence of so-called tumor infiltrating lymphocytes in tumor tissue and overall patient survival. Stratification of cancer patients based on immuno-predictors both in the plasma and directly in the tumor microenvironment makes it possible to identify suitable candidates for rediscovered modern anti-tumor immunotherapy, which can already be considered a standard therapeutic modality. In our projects, we focused on the identification of biomarkers that...
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Psychological and social aspects of coping with oncological gynecological illnesses (focused on breast cancer)
Šreibrová, Lenka ; Niederlová, Markéta (advisor) ; Šivicová, Gabriela (referee)
The thesis "Psychological and social aspects of coping with oncological gynecokogical illnesses (focused on breast cancer)" studies the demands and difficulties which women diagnosed with breast cancer are delaing with. In the theoretical part, attention is given to breast tumor and to the stages of the illness. It shows the needs and problems the women face and the possibilities of psychological help. This part of my thesis also describes different types of cure and its specifics and the changes it brings to the women's life. It is followed by coping strategies and defence mechanisms. In conclusion, the effects of the illness on personal relationships are outlined. In the empirical part, we map supporting psychological and other factors which helped with the treatment and with coping with it. The empirical part comprises 11 individual interviews with women who had breast cancer. The research methodology is supplemented with The Life Satisfaction Inventory. In the interviews we also focused on the factors of health care which were helping and the ones that could be improved. The results of the mapping qualitative study indicated two most important factors which helped the women to cope with this serious illness. It was social support and active coping strategies. In the sphere of health care, the...
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Role of selected ABC transporters in breast cancer development
Perglerová, Karolína ; Souček, Pavel (advisor) ; Stiborová, Marie (referee)
Breast cancer is a leading cause of death among women in many countries. In the treatment of the breast cancer cytotoxic drugs (chemotherapy) are often used. Interindividual differences of drug response are an important cause of treatment failures. Bioavailability also depends on a major extent from the expression and activity of drug transport across biomembranes. In particular efflux transporters of the ATP-binding cassette family such as ABCB1, ABCC1 and ABCC2 have been identified as major determinants of chemoresistance in tumor cells. It was hypothesized that variance in the gene expression of membrane transporters and their genetic variance could explain at least in part interindividual differences of pharmacokinetics and clinical outcome of a variety of drugs. This thesis focuses on the functional significance of gene expression of ABCB1, ABCC1 and ABCC2 and single nucleotide polymorphisms in ABCC1 gene.
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Proposal of the digitization of analog mammography centers
Večeřa, Martin ; Zavadil, Pavel (advisor) ; Vachoušek, Jaromír (referee)
1 Abstract The aim of this bachelor thesis is to propose digitalization of an analog mammographic center, its technical realization in its entirety including implementation, to compare digital and analog mammography and to evaluate its economic costs in a private senological center accredited by the Ministry of Health of the Czech Republic for breast screening. The economic return is expected to be in 15 000 examinations per year. From the calculations of annual costs and revenues the expected net profit of the mammographic center is 1 497 600 CZK. After 8 years of device-service the profit is 11 980 800 Kč. The fundamental lack of digital mammography is its price which is in comparison with the analog mammography much higher. This is an obstacle to current centers. Quality and rapid diagnostics of asymptomatic women with the elimination of false negative findings speak for digitizing the mammographic screening centers. In the future we can expect an extension of digital mammographs. Keywords: digital mammography, analog mammography, digital, mammograph, breast screening, economic return, price, mammography center, senological center
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Women after mastectomy in the context of social work
Kašparová, Marie ; Havránková, Olga (advisor) ; Vodáčková, Daniela (referee)
The thesis " Women after Mastectomy in the context of Social Work " deals with the topic of diagnosis of breast cancer, treatments and their side effects, itself, however focuses mainly on the psychological and social consequences that come along with such a serious illness. It aims to outline the possibilities that women with this diagnosis can use , and ultimately points out the great potential of social work within the health care system. Powered by TCPDF (www.tcpdf.org)
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Nurse as a family members educator of cancer patients.
Vrtišková, Monika ; Kulhavá, Miluše (advisor) ; Podaná, Jana (referee)
This bachelor's thesis is focused on the issue of a nurse acting as an educator for relatives of cancer patients. Apart from professional medical care, cancer patients also need psychological support and care throughout all the stages of cancer. Support of their family is especially important. Education is a necessity for their psychological support. Part of this thesis deals with issues of breast cancer in female patients, the psychological difficulties they face during the illness and support of family members and education they can receive from a nurse. Key words: oncological illness, breast cancer, general nurse, education, educator, patient, family.
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Structure, function and importace of BRCA 1protein
Hojný, Jan ; Kleibl, Zdeněk (advisor) ; Falk, Martin (referee)
Studies of factors contributed to the development of hereditary breast and ovary cancers lead to the discovery of Breast Cancer 1 gene (BRCA1). The protein product of this tumor suppressor gene is nuclear phosphoprotein that plays a critical role in DNA repair and it is required for genome integrity control. The BRCA1 protein is the key component for correct assembly of reparation complexes formed in sites of DNA double strand breaks. Furthermore, BRCA1 protein is implicated in regulation of cell cycle checkpoints and it is also involved in regulation of gene expression in response to DNA damage. These activities suggest that BRCA1 protein plays a crucial role in orchestration of intracellular response to genotoxic DNA damage. Loss of BRCA1 functions leads to the DNA-damage repair mechanisms failure resulting in genomic instability and a tolerance of genomic alterations in affected cells. The genomic instability is the initial step toward early malignant transformation of cells lacking BRCA1 proteins. The aim of this work is to summarize the information about structure, functions known and the importance of BRCA1 protein with respect to the current discoveries enabling elucidation of versatile BRCA1-containing multiprotein complexes in which BRCA1 protein acts as the multiplatform interacting...
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Pharmacogenetic prediction of tamoxifen efficiacy and adverse effects in hormonal dependent breast karcinoma patients.
Argalácsová, Soňa ; Slanař, Ondřej (advisor) ; Vrána, David (referee) ; Paluch, Zoltán (referee)
ABSTRACT/SUMMARY Background: The clinical efficacy of tamoxifen therapy may be modified by the drug-metabolizing enzymes and transporting molecules involved into the pharmacokinetics of tamoxifen. The aim of this study was to evaluate the association of CYP2D6, ABCB1 polymorhisms and comedication with efficacy and safety of tamoxifen treatment. Methods: Totally 258 women with hormonal positive breast carcinoma were retrospectively evaluated in relation to CYP2D6, ABCB1 polymorphisms and comedication. Results: CYP2D6 polymorphisms or co-medication affecting CYP2D6 activity demonstrated no statistically significant effect on the efficacy of tamoxifen therapy or adverse event incidence; there was only a trend towards shortening the time to event (TTE) in CYP2D6 poor metabolizers. ABCB1 polymorphism rs2032582 was not associated with clinical outcomes, while a trend towards an increase of TTE in variant allele carriers was noted. The ABCB1 polymorphism rs1045642 demonstrated statistical significance in premenopausal patients (p = 0.0012, HR 0.69 (95% CI 0.21 to 2.31), and its significant association was noted with gynaecological /vasomotor adverse events (p = 0.0221, HR = 1.0588), with no evidence of the influence on the incidence and onset of venous complications. Conclusions: Although this work did not show...
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