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The role of glial cells after ischemic stroke and their therapeutic potential.
Gorgol, Anastasija ; Kriška, Ján (advisor) ; Danačíková, Šárka (referee)
Stroke is one of the most common causes of death and disability worldwide. It causes a disruption in the blood flow in the brain. It affects neurons, but also glial cells, which play important roles in the course of the disease. The aim of this bachelor thesis is to provide an overview of the possible therapeutic use of glial cells in ischemic stroke (focal cerebral ischemia). The work also provides an overview of the main types of glial cells in the central nervous system, describes the function of individual glia in the healthy brain and during ischemia, and focuses on their potential in neuroprotection and brain regeneration.
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Case Study of Physiotherapeutic Care for a Patient Diagnosed with Ischemic Stroke
Jansová, Doubravka ; Vláčilová, Ivana (advisor) ; Vomáčková, Helena (referee)
Author: Doubravka Jansová Supervisor: PhDr. Ivana Vláčilová, Ph.D. Title: Case Study of Physiotherapeutic Care for a Patient Diagnosed with Ischemic Stroke Objectives: The aim of this bachelor thesis was to summarize theoretical knowledge about ischemic stroke and to develop a case study of a patient after an ischemic stroke. Methods: The thesis is divided into a general and practical part. In the general part, the thesis focus on describing the theoretical background of this diagnosis using professional literature. The practical part presents a case study of a patient with whom I had the opportunity to collaborate during a continuous professional practice at the Rehabilitation Inpatient Department at Na Homolce Hospital in Prague from January 30 to February 9, 2024. The case study includes patient examination, proposed therapy based on initial values, daily therapy records, and evaluation of the subsequent therapy effect. Results: During several therapeutic sessions, most of the short-term physiotherapeutic plan goals were achieved, including preventing the development of spasticity, preventing muscle shortening, maintaining joint ranges of motion, improving the active mobility of the left extremities, improving the sitting and walking stereotype, and increasing independence in daily activities....
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Analysis of experimental ECG
Maršánová, Lucie ; Janoušek, Oto (referee) ; Ronzhina, Marina (advisor)
This diploma thesis deals with the analysis of experimental electrograms (EG) recorded from isolated rabbit hearts. The theoretical part is focused on the basic principles of electrocardiography, pathological events in ECGs, automatic classification of ECG and experimental cardiological research. The practical part deals with manual classification of individual pathological events – these results will be presented in the database of EG records, which is under developing at the Department of Biomedical Engineering at BUT nowadays. Manual scoring of data was discussed with experts. After that, the presence of pathological events within particular experimental periods was described and influence of ischemia on heart electrical activity was reviewed. In the last part, morphological parameters calculated from EG beats were statistically analised with Kruskal-Wallis and Tukey-Kramer tests and also principal component analysis (PCA) and used as classification features to classify automatically four types of the beats. Classification was realized with four approaches such as discriminant function analysis, k-Nearest Neighbours, support vector machines, and naive Bayes classifier.
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Software for ECG analysis
Plch, Vít ; Hejč, Jakub (referee) ; Ronzhina, Marina (advisor)
This bachelor thesis deals with design and construction of tool for analysing electrocardiograms. The theoretical part deals with the origin of the action potential, propagation of the action potential through conduction system of the heart, failure of electrical impulse propagation through the con-duction system; different aspects of disorders, which can be found in experimental electrograms recorded from animal isolated hearts (database of electrograms, the Department of Biomedical En-gineering, FEEC, BUT), are also discussed. Software for electrograms draw and annotation available on the DBME, namely EG_Anotation and EG_RR_View, are described. As a result, the design and construct of ECG_ANN, the tool for the electrograms annotation, is proposed with regard to the advantages and disadvantages of mentioned software. At the end of the bachelor thesis there are the guide for ECG_ANN and discussion about problems which appears in design and construct of this tool.
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Correlation dimension analysis for heart rate variability analysis
Ptáček, Ondřej ; Čmiel, Vratislav (referee) ; Janoušek, Oto (advisor)
Bachelor thesis deals with the analysis of heart rate variability (HRV). By focusing on the analysis of HRV in the time domain and mainly using correlation dimension. It is necessary to propose a methodology for evaluating changes in HRV data using these two techniques of analysis and the comparison of the two approaches. Subsequently create an application in MATLAB for analysis of HRV, which is able to evaluate the effect of changes in HRV caused by ischemia. In the last section it is necessary to discuss the results and the comparison of the two approaches to detect changes induced by ischemia.
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Detection of ischemia in ECG
Tichý, Pavel ; Smital, Lukáš (referee) ; Ronzhina, Marina (advisor)
This paper describes the manifestations of ischemia in the ECG signals and summarizes some methods allowing automatic detection of ischemia. Morphological features were then calculated from ECG signals available from UBMI and statistically evaluated to select features appropriate for further automatic classification. Multilayer feedforward neural network was used for classification of heart beats. The neural network was designed in Matlab. Classification performance up to 99.9% was obtained on available dataset.
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MR imaging and MR spectroscopy of human during physical stress (MR spectroscopy imaging, MR diffusometry, MR relaxometry etc.)
Šedivý, Petr ; Hájek, Milan (advisor) ; Haberlová, Jana (referee) ; Vymazal, Josef (referee)
The dissertation is concerned to in vivo phosphorus MR spectroscopy (31 P MRS) and 1 H MR imaging (MRI) of muscle in combination with physical workload. The theoretical part of the thesis describes methodology of 31 P MRS measurement and its clinical use in research of metabolic changes in diabetes, heart failure and peripheral artery disease (PAD). The results of the thesis are divided into methodical and clinical parts. Methodical results deal with the construction of experimental equipment, software modification and development, and show of the reproducibility of the dynamic 31 P MRS. The MRI after exercise was used to the describe involvement of the individual calf muscles to muscle contraction during pedal movement in MR compatible ergometer. The first part of the clinical results of the thesis describes changes in muscle metabolism during diabetes and critical ischemia. In patients with critical ischemia the effect of treatment by angioplasty or transplantation of mesenchymal stem cells was evaluated. In the second part of the clinical results the metabolism of patients with heart failure complicated by sideropenia was studied. In these patients the effect of experimental treatment by iron carboxymaltose was described.
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Potential role of opioids in neuroprotection
Gebauer, Martin ; Novotný, Jiří (advisor) ; Rudajev, Vladimír (referee)
The opioids have been used by mankind for more than two millennia, but effect and mechanism of their action on the cells has been unveiling in the last few decades. The mechanism itself is often still unknown, but its effect is observed only. There are several groups of opioid receptors which are able to bind opioids. These groups are characterized by their differe nt affinity to opioids, in some cases by their different effects on cells and by their representation in the various areas in the CNS. Thus, the effects induces by these opioid are very different in many cases. This thesis summarizes the current knowledge about coronary heart disease and the potential of opioids for the prevention and their effect during ischemia, also summarizes the effects of morphine on the CNS. During ischemia δ-opioid receptors play a major role, because they inhibit or block the proapoptotic effects of ischemia on many levels. These receptors are also involved in inducing and maintaining the animal hibernation and protect animal's body against very harmful effects of hibernation, e.g lack of oxygen and nutrients. Morphine is opioid which has been used as anesthetic for longest time. It is well-known opioid and it has the most known derivates. This thesis also summarizes most significant effects of morphine on...
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