|
|
Oral Contraceptive Consumption in the Czech Republic
Zahradniková, Barbara ; Ťupová, Lenka (advisor) ; Dvořáčková, Simona (referee)
Title: Oral Contraceptive Consumption in the Czech Republic Author: Barbara Zahradniková, DiS. Supervisor: PharmDr. Lenka Ťupová, Ph.D. Introduction: Hormonal contraception is a group of drugs used to prevent pregnancy. In addition, it is also used in the number of other indications, such as reducing the manifestations of acne vulgaris, reducing heavy menstrual bleeding, regulating the menstrual cycle or relieving premenstrual symptoms. Objective: The aim of the diploma thesis was to analyse and evaluate the consumption of all types of hormonal contraception in the Czech Republic in the period from 2008 to 2022 using data obtained from the database of the State Institute for Drug Control (SIDC). Methods: A retrospective consumption analysis was used for the evaluation. Consumption was evaluated based on the number of packages delivered to healthcare facilities in the period between 2008-2022. The obtained data were classified according to individual ATC codes and then compared according to established parameters, e.g. type of evaluated hormonal contraception or dosage form. Results: During the monitored period, the consumption of combined contraception clearly dominated (89,62 %) over the progestagen type of contraception (10,38 %). In the case of combined hormonal contraception, the largest part...
|
|
|
Antidepressant (SARI, NDRI, RIMA) Consumption in Czech Republic
Bucková, Veronika ; Horký, Pavel (advisor) ; Ťupová, Lenka (referee)
Antidepressant (SARI, NDRI, RIMA) Consumption in Czech Republic Charles University Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Veronika Bucková Supervisor: PharmDr. Pavel Horký, Ph.D. Antidepressants are drugs used mainly to treat pathologically low mood and anxiety disorders. The antidepressants focused in this work from the SARI, NDRI and RIMA groups are also used in the treatment of insomnia, smoking cessation, as support in weight reduction and in some psychogenic sexual dysfunctions. The goal of this work is to analyze the consumption of antidepressants from the SARI, NDRI and RIMA groups in Czech Republic. The data for this work were obtained from the database of the State Institute for Drug Control on the basis of mandatory reporting of the volume of drugs supplied by distributors to pharmacies and other medical facilities. Consumption was monitored in the period from 1.1.2008 to 31.12.2020. The DUR type methodology was used and consumption was expressed in the number of defined daily doses per thousand inhabitants per day (DID). The results confirm the rising trend of antidepressant consumption only in the case of trazodone (SARI), whose consumption increased 3.8 times compared to 2008. The reason for this growth is the use of trazodone as an...
|
|
|
SSRI Antidepressant Consumption in Czech Republic
Behrová, Júlia ; Horký, Pavel (advisor) ; Rejmanová, Anna (referee)
SSRI antidepressant consumption in Czech republic Author: Júlia Behrová Supervisor: PharmDr. Pavel Horký, PhD. Consultant: PharmDr. Eva Zimčíková, Ph.D Introduction: Selective serotonin reuptake inhibitors increase the available amount of neurotransmitter serotonin in synapses, resulting in their antidepressant and anxiolytic effect. Objective: The objective of this diploma thesis was to evaluate the consumption of SSRI antidepressants in the Czech Republic in the period from 01. 01. 2008 - 31. 12. 2018, based on the data on consumption from the State Institute of Drug Control (SIDC). Methods: The research consisted of a retrospective analysis of the SIDC database. The study included all approved SSRI in the Czech Republic. Drug Utilization Review was used in the thesis as a methodology. Drug consumption is calculated as the number of defined daily doses per thousand inhabitants per day (DID). The data on the number of residents was acquired from the Czech Statistical Office. Descriptive statistics and ATC/DDD methodology were applied. Results: The consumption of sertraline and escitalopram increased significantly during the period under review. For sertraline, the DID increased from an initial 8.623 to 15.513, increasing consumption by 1.8 fold. The greatest increase in consumption was observed...
|
|
|
The analysis of pharmacotherapy in patient suffered with dyslipidemia in Greece I.
Mavrovouniotis, Konstantinos - Parmenion ; Vlček, Jiří (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy The analysis of pharmacotherapy in patients suffering from hyperlipidemia (Diploma Thesis) Mentor of Diploma Thesis Prof. PharmDr. Jiří Vlček, Ph.D. Mavrovouniotis Konstantinos- Parmenion Hradec Králové 2015 ABSTRACT ENGLISH The analysis of pharmacotherapy in patients suffering from hyperlipidemia Mavrovouniotis Konstantinos Mentor: Prof. Dr. Jiří Vlček, CSc. Introduction: Hyperlipidemia is a serious condition whereby the blood levels of lipids, cholesterol and triglycerides are abnormally elevated. This condition is generally asymptomatic but may lead to atherosclerotic heart disease and other types of cardiovascular pathology if not treated effectively. Various risk factors can affect the onset and severity of hyperlipidemia and those include genetic predisposition, hypertension, diabetes mellitus, obesity, poor diet, lack of regular exercise, smoking etc. Measurement and monitoring of blood levels of triglycerides, cholesterol and lipoproteins can be used as prevention method for assessing the risk for an individual to develop hyperlipidemia. Once a patient is diagnosed with the condition several approaches exist for the treatment. The main goal of the treatment is to reduce the risk of...
|
|
|
Analysis of self-medication with antibiotics in Kosovo
Veseli, Ardita ; Vlček, Jiří (advisor) ; Kostřiba, Jan (referee)
Title: Analysis of self-medication with antibiotics in Kosovo Student: Ardita Veseli Supervisor: Prof. PharmDr. Jiří Vlček, Ph.D. Specialist Supervisor: Mgr. T. Belkina Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Background: Self-medication is described as a behavior during which someone utilizes drugs for the purpose of treating self-diagnosed symptoms or disorders or the intermittent or continued use of a prescribed drug for chronic or recurrent disease or symptoms. When certain individuals self-medicate with antibiotics, they do it without any prior consultation with a physician. The antibiotics are bought from community pharmacies without a prescription, left-over antibiotics are used or they simply decide to follow the advice given from family members, neighbors or friends. Even though antibiotics are considered revolutionary therapeutic agents in order to eradicate microbes, the repeated and improper antibiotic consumption is contributing to the increased prevalence of antibiotic resistance which nowadays is one of the world's most pressing health problems. Aim: The main goal of the theoretical part is to describe self-medication with antibiotics, the patterns influencing it and some complications associated with this...
|
|
|
Tricyclic Antidepressant Consumption in Czech Republic
Květenská, Zuzana ; Horký, Pavel (advisor) ; Kostřiba, Jan (referee)
Ticyclic Antidepressants Consumption In Czech Republic Charles University Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Zuzana Květenská Supervisor: PharmDr. Pavel Horký, Ph.D. Tricyclic antidepressants are one of the oldest groups of antidepressants. Except for indication for depression, they are used in the therapy of chronic pain or enuresis nocturna in children. Nowadays, tricyclic antidepressants are drug of the first choice only in some types of neuropathic pain, and in other indications they have been replaced by newer substances with a lower occurrence of side effects. The aim of this works is to find out how consumption of tricyclic antidepressants has developed and what share in utilization of antidepressants they represent. Data for this work were obtained from the State Institute for Drug Control of the Czech Republic; namely from distributors' report about supplies of medicinal products to pharmacies and healthcare facilities, sellers of selected medicinal products, other distributors and veterinary doctors. Utilization was evaluated for the period from 1 January 2008 to 31 December 2018 with DUR (drug utilization review). For evaluation, a defined daily dose per 1000 inhabitants per day and methods of descriptive statistics was selected. A...
|
|
|
Tricyclic Antidepressant Consumption in Czech Republic
Květenská, Zuzana ; Horký, Pavel (advisor) ; Kostřiba, Jan (referee)
Ticyclic Antidepressants Consumption In Czech Republic Charles University Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Zuzana Květenská Supervisor: PharmDr. Pavel Horký, Ph.D. Tricyclic antidepressants are one of the oldest groups of antidepressants. Except for indication for depression, they are used in the therapy of chronic pain or enuresis nocturna in children. Nowadays, tricyclic antidepressants are drug of the first choice only in some types of neuropathic pain, and in other indications they have been replaced by newer substances with a lower occurrence of side effects. The aim of this works is to find out how consumption of tricyclic antidepressants has developed and what share in utilization of antidepressants they represent. Data for this work were obtained from the State Institute for Drug Control of the Czech Republic; namely from distributors' report about supplies of medicinal products to pharmacies and healthcare facilities, sellers of selected medicinal products, other distributors and veterinary doctors. Utilization was evaluated for the period from 1 January 2008 to 31 December 2018 with DUR (drug utilization review). For evaluation, a defined daily dose per 1000 inhabitants per day and methods of descriptive statistics was selected. A...
|
|
|
Estimation of illegal drug consumption in Kazakhstan
Ayapbekova, Dinara ; Vopravil, Jiří (advisor) ; Radimecký, Josef (referee)
Background: The republic of Kazakhstan is located on the "Northern Route" by which opiates are smuggled from Afghanistan to the Russian Federation and further into the European Union. For this reason, the state is under constant high risk of the drugs leaking to the local market, leading to drug abuse and related issues within the population. The drug situation in Kazakhstan is further complicated by the internal factor of the Chuy Valley which features the largest area of wild- growing cannabis in the world. The aim of this thesis is to estimate the consumption of cannabis-derived drugs and heroin in Kazakhstan based on the latest national and international reports and research. In terms of research, the thesis examines which organisations collect statistical information on users of illegal drugs and what methods are used to do so. Methods: the data analysis consisted of a secondary analysis of existing collected data through quantitative descriptive statistics and a qualitative analysis of individual international and national reports. Drug consumption was estimated based on demand. Results: According to estimates, there were 127,800 problem drug users in Kazakhstan in 2014; the total volume of consumed heroin was estimated to more than 46 tonnes. The estimated consumption of cannabis drugs in...
|
|
|
SSRI Antidepressant Consumption in Czech Republic
Behrová, Júlia ; Horký, Pavel (advisor) ; Rejmanová, Anna (referee)
SSRI antidepressant consumption in Czech republic Author: Júlia Behrová Supervisor: PharmDr. Pavel Horký, PhD. Consultant: PharmDr. Eva Zimčíková, Ph.D Introduction: Selective serotonin reuptake inhibitors increase the available amount of neurotransmitter serotonin in synapses, resulting in their antidepressant and anxiolytic effect. Objective: The objective of this diploma thesis was to evaluate the consumption of SSRI antidepressants in the Czech Republic in the period from 01. 01. 2008 - 31. 12. 2018, based on the data on consumption from the State Institute of Drug Control (SIDC). Methods: The research consisted of a retrospective analysis of the SIDC database. The study included all approved SSRI in the Czech Republic. Drug Utilization Review was used in the thesis as a methodology. Drug consumption is calculated as the number of defined daily doses per thousand inhabitants per day (DID). The data on the number of residents was acquired from the Czech Statistical Office. Descriptive statistics and ATC/DDD methodology were applied. Results: The consumption of sertraline and escitalopram increased significantly during the period under review. For sertraline, the DID increased from an initial 8.623 to 15.513, increasing consumption by 1.8 fold. The greatest increase in consumption was observed...
|
|
|
Dual Antidepressant Consumption in Czech Republic
Čiháková, Kristýna ; Horký, Pavel (advisor) ; Malý, Josef (referee)
Dual Antidepressant Consumption in the Czech Republic Author: Kristýna Čiháková Supervisor: PharmDr. Pavel Horký, Ph.D. Consultant: PharmDr. Kateřina Malá, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Antidepressants are widely used in many indications. Dual antidepressants are prescribed in treatment of depressive disorder, anxiety disorder, in pain therapy and insomnia. Besides that, there are trials to prove the efficacy of dual antidepressants in different indications. Generally, antidepressant consumption in the Czech Republic is increasing. The question is, what the real proportion of dual antidepressant consumption is. Objective: As the objective, dual antidepressant consumption was analysed. Methods: The consumption of antidepressants venlafaxine, duloxetine, mirtazapine and mianserin was performed in the period from 1 January 2008 to 31 December 2018. The State Institute for Drug Control (SÚKL) database was used. The data were described by descriptive statistics. The drug consumption in Defined Daily Doses (DDD) was converted into Defined Daily Dose/1,000 inhabitants/day (DID). In addition, comparison of use of particular dual antidepressant doses was made. Results: Overall, the relative consumption of dual...
|
guest ::
