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Acoustic stimulation of Slow wave sleep and its influence on consolidation of declarative memory in insomnia
Orendáčová, Mária ; Kopřivová, Jana (advisor) ; Kelemen, Eduard (referee)
Slow-wave sleep plays an important role in consolidation of declarative memory. From electrophysiological point of view, this process is dependent on a common occurrence and mutual integration of neocortical slow oscillations (< 1 Hz), hippocampal sharp-wave ripples (150-250 Hz) and thalamo-cortical sleep spindles (10-15 Hz). Previous studies demonstrated that periodic acoustic stimulation by pink noise pulses applied at frequency of sleep slow oscillation during slow wave sleep leads to prolongation of slow wave sleep and to enhancement in declarative memory performance in normal sleepers. Our study investigated this kind of periodic acoustic stimulation in its relation to sleep architecture and declarative memory of people suffering from insomnia due to which there often comes to a reduction in slow wave sleep which positively correlates with worsening of declarative memory performance. Our aim was to investigate if this kind of comparatively non-invasive brain stimulation has a potential to increase a total length of slow wave sleep and enhance declarative memory performance in insomnia. Our study revealed acoustic stimulation neither improved declarative memory performance nor it increased total length of slow-wave sleep. No positive association was found between level of declarative memory...
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Acoustic stimulation of Slow wave sleep and its influence on consolidation of declarative memory in insomnia
Orendáčová, Mária ; Kopřivová, Jana (advisor) ; Kelemen, Eduard (referee)
Slow-wave sleep plays an important role in consolidation of declarative memory. From electrophysiological point of view, this process is dependent on a common occurrence and mutual integration of neocortical slow oscillations (< 1 Hz), hippocampal sharp-wave ripples (150-250 Hz) and thalamo-cortical sleep spindles (10-15 Hz). Previous studies demonstrated that periodic acoustic stimulation by pink noise pulses applied at frequency of sleep slow oscillation during slow wave sleep leads to prolongation of slow wave sleep and to enhancement in declarative memory performance in normal sleepers. Our study investigated this kind of periodic acoustic stimulation in its relation to sleep architecture and declarative memory of people suffering from insomnia due to which there often comes to a reduction in slow wave sleep which positively correlates with worsening of declarative memory performance. Our aim was to investigate if this kind of comparatively non-invasive brain stimulation has a potential to increase a total length of slow wave sleep and enhance declarative memory performance in insomnia. Our study revealed acoustic stimulation neither improved declarative memory performance nor it increased total length of slow-wave sleep. No positive association was found between level of declarative memory...
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Neurobiological Correlates of Episodic-like Memory
Oravcová, Ivana ; Nekovářová, Tereza (advisor) ; Stuchlík, Aleš (referee)
Declarative memory is characterized as a conscious, explicit memory. Declarative memory consists of two essential systems, semantic memory and episodic memory. Episodic memory enables us to recall specific past events. A simplified model, so called Episodic-like memory is often used to study episodic memory mechanisms. According to this model, all events are stored in a contextual framework consisting of three basic components: identity of the object ('what' happened), temporal information ('when' it occurred) and spatial information ('where' did it happen). This type of memory is testable not only in humans but also in animal models. Aim of this diploma thesis is to study the neuronal substrate of individual components of episodic memory in healthy volunteers by means of functional magnetic resonance imaging (fMRI) and ecologically valid tasks designed in virtual reality environment. Results obtained in the fMRI paradigm show that apart from common neuronal substrate of episodic memory, additional brain structures are responsible for recollection of individual components of the episodic-like memory. Behavioral data indicate that the demands of the recollection of individual components is not equivalent. Additional analyses with parcellation of the brain to individual structures and consecutive...
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