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The use of natural antibiotics and herbal medicine in the treatment of SIBO
Svitavská, Jana ; Vaníčková, Zdislava (advisor) ; Šťovíček, Jan (referee)
This bachelor thesis deals with the syndrome of small intestinal bacterial overgrowth (SIBO), a gastrointestinal disorder caused by increased total bacterial counts and abnormal microbiome composition in the small intestine. SIBO often manifests through non-specific dyspeptic symptoms, including gas bloating, abdominal pain, diarrhea, malabsorption and malnutrition. A non-invasive breath test is most commonly used to diagnose SIBO. Treatment of SIBO should include therapy for the underlying disease, bacterial eradication and nutritional support. The main aim of this bachelor thesis is to investigate the efficacy of herbal preparations and natural antibiotics in the treatment of SIBO and to highlight the potential usage of these antibacterial agents as a stand-alone or adjunctive therapy to conventional treatment. Another aim is to confirm the hypothesis that it is impossible to predict the diagnosis of SIBO based on gastrointestinal symptoms. Therefore, treating this disease empirically without confirmation by laboratory examination is not appropriate. The data was collected in the Gastroenterology Laboratory of the Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University in Prague and in VFN. The prevalence of gastrointestinal symptoms and other...
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Individual ....
Tomeček, David ; Kocna, Petr (advisor) ; Průša, Richard (referee)
13 C-MTG breath tests are used for exocrine pancreas diagnostics. It is a quite expansive test and its usage has never been tested in clinical practice in long time horizon. This study is engaged in pre-analytical phase and contains a group of 4 people who were tested for 6 months and this is the first study ever that has been proceeded in a long time horizon. The half-year profile of these 4 people showed that some of those results are spread of tens percents against its average. The test of CO2 stability showed that the value of CO2 is independent on the temperature which the breath bag is stored in. Its concentration was same for the time of 7 days. Now we can say that the breath bags are insensitive in case of transporting and storage. The question is, why the value of delta 13 C/12 C changed. The results of this study point on fact that values of cumulative dosage recovery of these 4 people did change.
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Laboratory functional diagnostics of malabsorption syndromes with the focus on lactose intolerance
Pluhařová, Apolena ; Kocna, Petr (advisor) ; Kohout, Pavel (referee)
This diploma thesis deals with laboratory functional diagnostics of malabsorption syndromes. Especially the functional diagnosis of lactose intolerance. The golden standard for the functional diagnosis of lactose intolerance is the breath test. The aim of the study was to determine the prevalence of lactose intolerance (LI) using a lactose breath test when consuming a dose of 20 g of lactose in patients with gastrointestinal symptoms and in volunteers who do not show gastrointestinal problems. Part of the research was also to examine the symptoms that led the individual to see a doctor and undergo a lactose breath test. The method consisted in the evaluation of the results of breath tests, which were performed on patients and volunteers in the gastroenterological laboratory of the 1st Medical Faculty of Charles University and the General Hospital. A questionnaire was given to everyone to evaluate the symptoms of LI and the phenomena leading to malabsorption. Lactose intolerance was confirmed in 92 % of patients and 79 % of volunteers. The most reported symptoms in the patient sample were typical gastrointestinal LI-related problems: gastric and intestinal problems after milk consumption (85 % of patients), gastric and intestinal problems after consumption of dairy products (85 % of patients),...
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Individual ....
Tomeček, David ; Kocna, Petr (advisor) ; Průša, Richard (referee)
13 C-MTG breath tests are used for exocrine pancreas diagnostics. It is a quite expansive test and its usage has never been tested in clinical practice in long time horizon. This study is engaged in pre-analytical phase and contains a group of 4 people who were tested for 6 months and this is the first study ever that has been proceeded in a long time horizon. The half-year profile of these 4 people showed that some of those results are spread of tens percents against its average. The test of CO2 stability showed that the value of CO2 is independent on the temperature which the breath bag is stored in. Its concentration was same for the time of 7 days. Now we can say that the breath bags are insensitive in case of transporting and storage. The question is, why the value of delta 13 C/12 C changed. The results of this study point on fact that values of cumulative dosage recovery of these 4 people did change.
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