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Chirality and its importance in environmental organic analysis
Svobodová, Dagmar ; Friedl, Zdeněk (referee) ; Čáslavský, Josef (advisor)
This bachelor thesis is elaborated as literature search focused on the characterization of chirality and its importance for the environment. This work also gives review of the analytical methods and procedures aplicable for the chiral analysis of the organic pollutants. Obtained information showed that the importance of the chirality in the environmental chemistry is great. Individual enantiomers exhibit different toxicity and biological activity in the environment and therefore their monitoring by chiral analytical methods is essential.
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Chirality and its importance in environmental organic analysis
Svobodová, Dagmar ; Friedl, Zdeněk (referee) ; Čáslavský, Josef (advisor)
This bachelor thesis is elaborated as literature search focused on the characterization of chirality and its importance for the environment. This work also gives review of the analytical methods and procedures aplicable for the chiral analysis of the organic pollutants. Obtained information showed that the importance of the chirality in the environmental chemistry is great. Individual enantiomers exhibit different toxicity and biological activity in the environment and therefore their monitoring by chiral analytical methods is essential.
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Chiral analysis of alfa-diimine Ru(II) and Fe(II) complexes by capillary electrophoresis using sulfated cyclodextrins as stereoselectors
Sázelová, Petra ; Koval, Dušan ; Severa, Lukáš ; Teplý, Filip ; Kašička, Václav
A fast and efficient capillary electrophoretic method was developed for enantioseparation of Ru(II) and Fe(II) polypyridyl complexes using anionic randomly sulfated alfa-, beta-, and gamma-cyclodextrins (S-alfa-CD, S-beta-CD, and S-gamma-CD) and their heptakis-(2,3-diacetyl-6-sulfato)-derivatives (Ac-S-alfa-CD, Ac-S-beta-CD, and Ac-S-gamma-CD) as chiral selectors. S-alfa-CD and S-gamma-CD were found to be the best chiral selectors providing high resolutions and short analysis times. The method was applied for the assessment of chiral purity of some batches of [Ru(bpy)3]2+ catalyst.
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Capillary electrophoresis applied to chiral analysis of helquats and characterization of their intermediates and interconversion barriers using randomly and single isomer sulfated cyclodextrins as stereoselectors
Kašička, Václav ; Koval, Dušan ; Sázelová, Petra ; Severa, Lukáš ; Vávra, Jan ; Adriaenssens, Louis ; Sonawane, Manoj R. ; Teplý, Filip
Capillary electrophoresis in acidic sodium phosphate background electrolyte, pH 2.4, with randomly sulfated alfa-, beta- and gamma-cyclodextrins as chiral selectors was applied to fast, high-resolution separation of enantiomers of a series of 35 helquats, a new class of N-heteroaromatic dicationic helicene-like species. The developed methodology was employed for evaluation of preparative enantioresolution procedures of helquats, for monitoring their racemization and for determination of interconversion barrier of helquat enantiomers.
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Chiral analysis of beta-alanyl-D,L-tyrosine and its derivatives by capillary electrophoresis with 2-hydroxypropyl-beta-cyclodextrin stereoselector
Sázelová, Petra ; Šolínová, Veronika ; Schimperková, Tereza ; Mášová, Alice ; Jiráček, Jiří ; Kašička, Václav
A new capillary electrophoretic method was developed for separation of enantiomers of antimicrobial dipeptide betha-Ala-D,L-Tyr and its derivatives using 50 mM Tris-phosphate, pH 2.50, as background electrolyte and 2-hydroxypropyl-betha-cyclodextrin at concentrations 20 – 60 mg/mL as chiral selector. In addition, association constants of complexes of the enatiomers of dipeptide betha-Ala-D,L-Tyr and its derivatives with 2-hydroxypropyl-betha-cyclodextrin chiral selector were determined.
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Enantiomer separation and determination of helix inversion barrier of helical dications by capillary electrophoresis
Koval, Dušan ; Adriaenssens, Louis ; Severa, Lukáš ; Teplý, Filip ; Sázelová, Petra ; Kašička, Václav
Enantiomeric helical forms of dicationic helquats, a novel family of charged helicene-like molecules, have been separated by capillary electrophoresis (CE) using sodium-phosphate buffer, pH 2.5, as background electrolyte and sulfated beta- and gamma-cyclodextrins as chiral selectors. Additionally, CE was used to determine barrier to helix inversion of helquats.
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